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Hsph1 Gene Detail
Summary
  • Symbol
    Hsph1
  • Name
    heat shock 105kDa/110kDa protein 1
  • Synonyms
    Hsp105, HSP110, hsp110/105, hsp-E7I
  • Feature Type
    protein coding gene
  • IDs
    MGI:105053
    NCBI Gene: 15505
  • Gene Overview
    MyGene.info: HSPH1
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:149616843-149637155 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 89.18 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105053
protein coding gene Chr5:149614287-149637155 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030405
protein coding gene Chr5:155460133-155485494 (-)
A/J MGP_AJ_G0030378
protein coding gene Chr5:148824365-148847022 (-)
AKR/J MGP_AKRJ_G0030305
protein coding gene Chr5:153420209-153442358 (-)
BALB/cJ MGP_BALBcJ_G0030387
protein coding gene Chr5:150086667-150108665 (-)
C3H/HeJ MGP_C3HHeJ_G0030101
protein coding gene Chr5:154418400-154441780 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030842
protein coding gene Chr5:161163128-161186514 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028055
protein coding gene Chr5:143168365-143190691 (-)
CAST/EiJ MGP_CASTEiJ_G0029503
protein coding gene Chr5:154045147-154067035 (-)
CBA/J MGP_CBAJ_G0030079
protein coding gene Chr5:167948863-167970919 (-)
DBA/2J MGP_DBA2J_G0030223
protein coding gene Chr5:148477178-148499538 (-)
FVB/NJ MGP_FVBNJ_G0030177
protein coding gene Chr5:147730872-147753306 (-)
LP/J MGP_LPJ_G0030310
protein coding gene Chr5:156157322-156180668 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030213
protein coding gene Chr5:170050085-170072995 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030872
protein coding gene Chr5:153356788-153378793 (-)
PWK/PhJ MGP_PWKPhJ_G0029217
protein coding gene Chr5:147642233-147664424 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029053
protein coding gene Chr5:150663046-150684872 (-)
WSB/EiJ MGP_WSBEiJ_G0029580
protein coding gene Chr5:154173041-154195133 (-)



Homology
more
  • Human Ortholog
    HSPH1, heat shock protein family H (Hsp110) member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HSPH1, heat shock protein family H (Hsp110) member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSP105, HSP105A, HSP105B, NY-CO-25
  • Links
    NCBI Gene ID: 10808
    neXtProt AC: NX_Q92598
    UniProt: Q92598

  • Chr Location
    13q12.3; chr13:31134974-31163109 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to decreased susceptibility to ischemic brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15505 NCBI Gene Model | MGI Sequence Detail 20313 C57BL/6J ±  kb
transcript NM_013559 RefSeq | MGI Sequence Detail 3478 C57BL/6  
polypeptide Q61699 UniProt | EBI | MGI Sequence Detail 858 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000003410 heat shock protein 105 kDa
  • InterPro Domains
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
    IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
Molecular
Reagents
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  • All nucleic 260
    Genomic 1
    cDNA 258
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-32092, MGI:2140965
References
more
  • Summaries
    All 59
    Developmental Gene Expression 6
    Gene Ontology 13
    Phenotypes 10
  • Earliest
    J:30122 Yasuda K, et al., Cloning and expression of murine high molecular mass heat shock proteins, HSP105. J Biol Chem. 1995 Dec 15;270(50):29718-23
  • Latest
    J:231873 Mohamed BA, et al., Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice. Am J Respir Cell Mol Biol. 2014 Apr;50(4):817-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory