Cdkn1c
Gene Detail

Symbol Name ID

Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) MGI:104564

Synonyms

CDKI, Kip2, p57Kip2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

88.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)

Sequence Map

Chr7:143458350-143461050 bp, - strand From Ensembl annotation of GRCm38   2701 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:58  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 zebrafish

Protein SuperFamily: cyclin-dependent kinase inhibitor p57
Gene Tree: Cdkn1c

Human homologs

Human Homolog		CDKN1C, cyclin-dependent kinase inhibitor 1C (p57, Kip2)
NCBI Gene ID		1028
neXtProt AC		NX_P49918
Human Synonyms		BWCR, BWS, KIP2, p57, p57Kip2, WBS
Human Chr (Location)		11p15.5; chr11:2904448-2906995 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CDKN1C

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous mutants or heterozygotes with a mutant maternal allele have developmental defects including cleft palate, gastrointestinal defects and short limbs. Most mutants die at birth; survivors are growth retarded and have immature reproductive systems.

 
Human Diseases Modeled Using Mouse Cdkn1c (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell cycle, cell cycle arrest, ...
Component	cytoplasm, nucleus
Function	cyclin-dependent protein serine/threonine kinase inhibitor activity, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (183 records)
Data Summary: Results (392)    Tissues (224)    Images (63)
Theiler Stages: 4, 9, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	216
Northern blot	20
Western blot	8
RT-PCR	134

cDNA source data(196)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(243) Genomic(24) cDNA(198) Primer pair(16) Other(5)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000037664 (Evidence)
Entrez Gene	12577 (Evidence)
UniGene	168789
DFCI	TC1572312
DoTS	DT.101389917, DT.496075, DT.97359396
NIA Mouse Gene Index	U029509
Consensus CDS Project	CCDS22040.1, CCDS52463.1
International Mouse Knockout Project Status	Cdkn1c

Sequences

Length	Strain/Species
genomic	ENSMUSG00000037664	Ensembl Gene Model | MGI Sequence Detail	2701	C57BL/6J
transcript	ENSMUST00000167912	Ensembl | MGI Sequence Detail	1931	Not Applicable
polypeptide	ENSMUSP00000128828	Ensembl | MGI Sequence Detail	348	Not Applicable

All sequences(31) RefSeq(4) UniProt(3)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003175	Cyclin-dependent kinase inhibitor
Protein Ontology	PR:000005275	cyclin-dependent kinase inhibitor 1C

References

(Earliest) J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
(Latest) J:193430 Rossi L, et al., Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell. 2012 Sep 7;11(3):302-17
All references(248)

Other accession IDs

MGD-MRK-25998, MGI:2142098