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Cdkn1c
Gene Detail
 Symbol
Name
ID
Cdkn1c
cyclin-dependent kinase inhibitor 1C (P57)
MGI:104564
Synonyms CDKI, Kip2, p57Kip2
Feature Type protein coding gene
Genetic Map
Chromosome 7
88.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr7:143458350-143461050 bp, - strand
From Ensembl annotation of GRCm38

  2701 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:58  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 zebrafish

Protein SuperFamily: cyclin-dependent kinase inhibitor p57
Gene Tree: Cdkn1c

Human
homologs
Human Homolog CDKN1C, cyclin-dependent kinase inhibitor 1C (p57, Kip2)
NCBI Gene ID 1028
neXtProt AC  NX_P49918
Human Synonyms  BWCR, BWS, KIP2, p57, p57Kip2, WBS
Human Chr (Location)  11p15.5; chr11:2883218-2885832 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CDKN1C
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Homozygous mutants or heterozygotes with a mutant maternal allele have developmental defects including cleft palate, gastrointestinal defects and short limbs. Most mutants die at birth; survivors are growth retarded and have immature reproductive systems.
 
Human Diseases Modeled Using Mouse Cdkn1c (2)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process adrenal gland development, aging, ...
Component cytoplasm, nucleus
Function cyclin-dependent protein serine/threonine kinase inhibitor activity, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (198 records)
Data Summary: Results (547)    Tissues (351)    Images (127)
Theiler Stages: 4, 9, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 109
RNA in situ 271
Northern blot 20
Western blot 9
RT-PCR 138
cDNA source data(203)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(253) Genomic(24) cDNA(205) Primer pair(18) Other(6)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000037664 (Evidence)
Entrez Gene12577 (Evidence)
UniGene168789
DFCITC1572312
DoTSDT.101389917, DT.496075, DT.97359396
NIA Mouse Gene IndexU029509
Consensus CDS ProjectCCDS22040.1, CCDS52463.1
International Mouse Knockout Project StatusCdkn1c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037664 Ensembl Gene Model | MGI Sequence Detail 2701 C57BL/6J ±  kb
transcript ENSMUST00000167912 Ensembl | MGI Sequence Detail 1931 Not Applicable 
polypeptide ENSMUSP00000128828 Ensembl | MGI Sequence Detail 348 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(14) UniProt(3)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003175 Cyclin-dependent kinase inhibitor
Protein Ontology PR:000005275 cyclin-dependent kinase inhibitor 1C
References (Earliest) J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
(Latest) J:202337 Estrada KD, et al., Smad7 regulates terminal maturation of chondrocytes in the growth plate. Dev Biol. 2013 Oct 15;382(2):375-84
All references(266)
Other
accession IDs
MGD-MRK-25998, MGI:2142098

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory