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Bmp7 Gene Detail
Summary
  • Symbol
    Bmp7
  • Name
    bone morphogenetic protein 7
  • Synonyms
    OP1, osteogenic protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103302
    NCBI Gene: 12162
  • Gene Overview
    MyGene.info: BMP7
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:172868012-172940321 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 95.54 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    600 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103302
protein coding gene Chr2:172868012-172940321 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026949
protein coding gene Chr2:179105849-179178175 (-)
A/J MGP_AJ_G0026916
protein coding gene Chr2:171573605-171646019 (-)
AKR/J MGP_AKRJ_G0026887
protein coding gene Chr2:176749083-176821469 (-)
BALB/cJ MGP_BALBcJ_G0026925
protein coding gene Chr2:171974305-172046591 (-)
C3H/HeJ MGP_C3HHeJ_G0026667
protein coding gene Chr2:177130901-177204353 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027372
protein coding gene Chr2:184258227-184332514 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024742
protein coding gene Chr2:164814974-164889374 (-)
CAST/EiJ MGP_CASTEiJ_G0026125
protein coding gene Chr2:177826283-177899973 (-)
CBA/J MGP_CBAJ_G0026644
protein coding gene Chr2:191162541-191240987 (-)
DBA/2J MGP_DBA2J_G0026782
protein coding gene Chr2:170672445-170744441 (-)
FVB/NJ MGP_FVBNJ_G0026748
protein coding gene Chr2:169285395-169360436 (-)
LP/J MGP_LPJ_G0026883
protein coding gene Chr2:179036730-179116310 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026767
protein coding gene Chr2:194109763-194184215 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027429
protein coding gene Chr2:176752710-176829718 (-)
PWK/PhJ MGP_PWKPhJ_G0025862
protein coding gene Chr2:170459822-170535139 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025662
protein coding gene Chr2:175742019-175816803 (-)
WSB/EiJ MGP_WSBEiJ_G0026198
protein coding gene Chr2:177717299-177792154 (-)



Homology
more
  • Human Ortholog
    BMP7, bone morphogenetic protein 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BMP7, bone morphogenetic protein 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OP-1
  • Links
    NCBI Gene ID: 655
    neXtProt AC: NX_P18075
    UniProt: P18075

  • Chr Location
    20q13.31; chr20:57168753-57266651 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Bmp7 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    85 phenotypes from 9 alleles in 10 genetic backgrounds
    90 phenotypes from multigenic genotypes
    2 images
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Various homozygous targeted mutations result in postnatal lethality, a wide range of skeletal and cartilage abnormalities, renal dysplasia and polycystic kidney, and eye defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12162 NCBI Gene Model | MGI Sequence Detail 72310 C57BL/6J ±  kb
    transcript NM_007557 RefSeq | MGI Sequence Detail 3670 C57BL/6  
    polypeptide P23359 UniProt | EBI | MGI Sequence Detail 430 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 4
      cDNA 41
      Primer pair 11
      Other 13

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24186
    References
    more
    • Summaries
      All 427
      Developmental Gene Expression 313
      Diseases 1
      Gene Ontology 31
      Phenotypes 83
    • Earliest
      J:148755 Burgoyne PS, et al., XY follicle cells in ovaries of XX----XY female mouse chimaeras. Development. 1988 Dec;104(4):683-8
    • Latest
      J:264602 Gamer LW, et al., The Role of Bmp2 in the Maturation and Maintenance of the Murine Knee Joint. J Bone Miner Res. 2018 Sep;33(9):1708-1717

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory