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Bmp7
Gene Detail
 Symbol
Name
ID
Bmp7
bone morphogenetic protein 7
MGI:103302
Synonyms OP1, osteogenic protein 1
Feature Type protein coding gene
Genetic Map
Chromosome 2
95.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:172868012-172940321 bp, - strand
From VEGA annotation of GRCm38

  72310 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20410  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp7

Human
homologs
Human Homolog BMP7, bone morphogenetic protein 7
NCBI Gene ID 655
neXtProt AC  NX_P18075
Human Synonyms  OP-1
Human Chr (Location)  20q13; chr20:57168753-57266651 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(4) Targeted(13) Transgenic(1)
Incidental mutations (data from APF )
 
Various homozygous targeted mutations result in postnatal lethality, a wide range of skeletal and cartilage abnormalities, renal dysplasia and polycystic kidney, and eye defects.
 
Phenotype Images(1)
Interactions
Bmp7 interacts with 231 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (88 annotations)
Process anatomical structure formation involved in morphogenesis, axon guidance, ...
Component extracellular matrix, extracellular region, ...
Function BMP receptor binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (250 records)
Data Summary: Results (730)    Tissues (404)    Images (229)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 17
RNA in situ 494
In situ reporter (knock in) 152
Northern blot 31
RT-PCR 36
cDNA source data(26)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(4) cDNA(31) Primer pair(10) Other(10)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016684 (Evidence)
Ensembl Gene ModelENSMUSG00000008999 (Evidence)
Entrez Gene12162 (Evidence)
DFCITC1581559, TC1650571, TC1715056
DoTSDT.50315357, DT.91349411
NIA Mouse Gene IndexU023723, U253722
Consensus CDS ProjectCCDS17136.1
International Mouse Knockout Project StatusBmp7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016684 VEGA Gene Model | MGI Sequence Detail 72310 C57BL/6J ±  kb
transcript OTTMUST00000040404 VEGA | MGI Sequence Detail 3670 Not Applicable 
polypeptide OTTMUSP00000018052 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(606 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000168 BMP7
References (Earliest) J:148755 Burgoyne PS, et al., XY follicle cells in ovaries of XX----XY female mouse chimaeras. Development. 1988 Dec;104(4):683-8
(Latest) J:208421 Klimova L, et al., Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
All references(340)
Other
accession IDs
MGD-MRK-24186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory