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Bmp7 Gene Detail
Summary
  • Symbol
    Bmp7
  • Name
    bone morphogenetic protein 7
  • Synonyms
    OP1, osteogenic protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103302
    NCBI Gene: 12162
  • Gene Overview
    MyGene.info: BMP7
Location & Maps
more
  • Sequence Map
    Chr2:172868012-172940321 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      72310 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 95.54 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    BMP7, bone morphogenetic protein 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BMP7, bone morphogenetic protein 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OP-1
  • Links
    NCBI Gene ID: 655
    neXtProt AC: NX_P18075

  • Chr Location
    20q13; chr20:57168753-57266651 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    82 phenotypes from 9 alleles in 10 genetic backgrounds
    89 phenotypes from multigenic genotypes
    2 images
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Gene trapped
    4
  • Targeted
    14
  • Transgenic
    1
  • Incidental Mutations
    APF , CvDC
Various homozygous targeted mutations result in postnatal lethality, a wide range of skeletal and cartilage abnormalities, renal dysplasia and polycystic kidney, and eye defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016684 VEGA Gene Model | MGI Sequence Detail 72310 C57BL/6J ±  kb
transcript OTTMUST00000040404 VEGA | MGI Sequence Detail 3670 Not Applicable  
polypeptide OTTMUSP00000018052 VEGA | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    600 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR017948 Transforming growth factor beta, conserved site
    IPR001839 Transforming growth factor-beta, C-terminal
    IPR001111 Transforming growth factor-beta, N-terminal
    IPR015615 Transforming growth factor-beta-related
Molecular
Reagents
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  • All nucleic 56
    Genomic 4
    cDNA 31
    Primer pair 10
    Other 11

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-24186
References
more
  • Summaries
    All 378
    Developmental Gene Expression 281
    Gene Ontology 28
    Phenotypes 76
  • Earliest
    J:148755 Burgoyne PS, et al., XY follicle cells in ovaries of XX----XY female mouse chimaeras. Development. 1988 Dec;104(4):683-8
  • Latest
    J:231462 Kaltcheva MM, et al., BMPs are direct triggers of interdigital programmed cell death. Dev Biol. 2016 Mar 15;411(2):266-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory