Bmp7
Gene Detail

Symbol Name ID

Bmp7 bone morphogenetic protein 7 MGI:103302

Synonyms

OP1, osteogenic protein 1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

95.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:172868012-172940321 bp, - strand From VEGA annotation of GRCm38   72310 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20410  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Bmp7

Human homologs

Human Homolog		BMP7, bone morphogenetic protein 7
NCBI Gene ID		655
neXtProt AC		NX_P18075
Human Synonyms		OP-1
Human Chr (Location)		20q13; chr20:55743809-55841707 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(18) : Targeted(13) Gene trapped(4) Transgenic(1)
 

Various homozygous targeted mutations result in postnatal lethality, a wide range of skeletal and cartilage abnormalities, renal dysplasia and polycystic kidney, and eye defects.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (88 annotations)

Process	anatomical structure formation involved in morphogenesis, axon guidance, ...
Component	extracellular matrix, extracellular region, ...
Function	BMP receptor binding, cytokine activity, ...

External Resources: FuncBase

Expression

Literature Summary: (234 records)
Data Summary: Results (714)    Tissues (399)    Images (225)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	17
RNA in situ	482
In situ reporter (knock in)	152
Northern blot	31
RT-PCR	32

cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(53) Genomic(4) cDNA(30) Primer pair(9) Other(10)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016684 (Evidence)
Ensembl Gene Model	ENSMUSG00000008999 (Evidence)
Entrez Gene	12162 (Evidence)
DFCI	TC1581559, TC1650571, TC1715056
DoTS	DT.50315357, DT.91349411
NIA Mouse Gene Index	U023723, U253722
Consensus CDS Project	CCDS17136.1
International Mouse Knockout Project Status	Bmp7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016684	VEGA Gene Model | MGI Sequence Detail	72310	C57BL/6J
transcript	OTTMUST00000040404	VEGA | MGI Sequence Detail	3670	Not Applicable
polypeptide	OTTMUSP00000018052	VEGA | MGI Sequence Detail	430	Not Applicable

All sequences(28) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(420 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000000168	BMP7

References

(Earliest) J:148755 Burgoyne PS, et al., XY follicle cells in ovaries of XX----XY female mouse chimaeras. Development. 1988 Dec;104(4):683-8
(Latest) J:192712 Meadows SM, et al., Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012 Jan 6;110(1):34-46
All references(319)

Other accession IDs

MGD-MRK-24186