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Six2 Gene Detail
Summary
  • Symbol
    Six2
  • Name
    sine oculis-related homeobox 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102778
    NCBI Gene: 20472
  • Gene Overview
    MyGene.info: SIX2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:85684277-85688274 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 55.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    61 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102778
protein coding gene Chr17:85662742-85688274 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024089
protein coding gene Chr17:88955793-88959747 (-)
A/J MGP_AJ_G0024048
protein coding gene Chr17:86098910-86102867 (-)
AKR/J MGP_AKRJ_G0024017
protein coding gene Chr17:87500363-87504305 (-)
BALB/cJ MGP_BALBcJ_G0024049
protein coding gene Chr17:85940074-85944033 (-)
C3H/HeJ MGP_C3HHeJ_G0023814
protein coding gene Chr17:88389141-88393098 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024494
protein coding gene Chr17:92072459-92076414 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021933
protein coding gene Chr17:81289200-81293262 (-)
CAST/EiJ MGP_CASTEiJ_G0023293
protein coding gene Chr17:89190831-89194887 (-)
CBA/J MGP_CBAJ_G0023788
protein coding gene Chr17:95896137-95900393 (-)
DBA/2J MGP_DBA2J_G0023916
protein coding gene Chr17:84559949-84563902 (-)
FVB/NJ MGP_FVBNJ_G0023882
protein coding gene Chr17:84052872-84056863 (-)
LP/J MGP_LPJ_G0024000
protein coding gene Chr17:89718304-89722257 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023910
protein coding gene Chr17:95896464-95900437 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024539
protein coding gene Chr17:88019009-88022963 (-)
PWK/PhJ MGP_PWKPhJ_G0023038
protein coding gene Chr17:84159501-84163661 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022849
protein coding gene Chr17:84819221-84823259 (-)
WSB/EiJ MGP_WSBEiJ_G0023359
protein coding gene Chr17:88870026-88873983 (-)



Homology
more
  • Human Ortholog
    SIX2, SIX homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIX2, SIX homeobox 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 10736
    neXtProt AC: NX_Q9NPC8
    UniProt: Q9NPC8

  • Chr Location
    2p21; chr2:45005185-45009645 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56518
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SIX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 5 genetic backgrounds
    34 phenotypes from multigenic genotypes
    10 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die shortly after birth and exhibit abnormal kidney development. Abnormalities include small kidney, lack of ureteric bud branches throughout the kidney, increased apoptosis and premature and arrested nephron development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024134 Ensembl Gene Model | MGI Sequence Detail 3998 C57BL/6J ±  kb
    transcript ENSMUST00000163568 Ensembl | MGI Sequence Detail 2119 Not Applicable  
    polypeptide ENSMUSP00000125871 Ensembl | MGI Sequence Detail 296 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 13
      Primer pair 3
      Other 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19686
    References
    more
    • Summaries
      All 187
      Developmental Gene Expression 141
      Gene Ontology 22
      Phenotypes 33
    • Earliest
      J:23775 Oliver G, et al., Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
    • Latest
      J:264647 O'Brien LL, et al., Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. PLoS Genet. 2018 Jan;14(1):e1007181

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory