About   Help   FAQ
Six2
Gene Detail
Symbol

Name
ID
Six2
sine oculis-related homeobox 2
MGI:102778
Feature Type
protein coding gene
Genetic Map
Chromosome 17
55.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:85682910-85688274 bp, - strand
From VEGA annotation of GRCm38

  5365 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56518  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SIX2
Gene Tree: Six2

Human
homologs
SIX2, SIX homeobox 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10736
neXtProt AC: NX_Q9NPC8

Human Chr (Location): 2p21; chr2:45005182-45009610 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene die shortly after birth and exhibit abnormal kidney development. Abnormalities include small kidney, lack of ureteric bud branches throughout the kidney, increased apoptosis and premature and arrested nephron development.
 
Phenotype Images(10)
Interactions
Six2 interacts with 92 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process anterior/posterior axis specification, cell migration, ...
Component cytoplasm, nuclear membrane, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (99 records)
Data Summary: Results (501)    Tissues (295)    Images (112)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 452
Northern blot 1
Western blot 18
RT-PCR 8
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase six2 ; ZFIN six2a    NEW 
Molecular
reagents
All nucleic(19) cDNA(13) Primer pair(3) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000040063 (Evidence)
Ensembl Gene Model ENSMUSG00000024134 (Evidence)
Entrez Gene 20472 (Evidence)
UniGene 5039
DFCI TC1590264
DoTS DT.87040511, DT.55164665
NIA Mouse Gene Index U038120
Consensus CDS Project CCDS29007.1
International Mouse Phenotyping Consortium Status Six2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040063 VEGA Gene Model | MGI Sequence Detail 5365 C57BL/6J ±  kb
transcript OTTMUST00000104038 VEGA | MGI Sequence Detail 2119 Not Applicable 
polypeptide OTTMUSP00000058173 VEGA | MGI Sequence Detail 296 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000014897 homeobox protein SIX2
References
(Earliest) J:23775 Oliver G, et al., Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
(Latest) J:221164 Di Giovanni V, et al., Fibroblast growth factor receptor-Frs2alpha signaling is critical for nephron progenitors. Dev Biol. 2015 Apr 1;400(1):82-93
All references(141)
Other
accession IDs
MGD-MRK-19686

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory