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Six2 Gene Detail
Summary
  • Symbol
    Six2
  • Name
    sine oculis-related homeobox 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102778
    NCBI Gene: 20472
  • Gene Overview
    MyGene.info: SIX2
Location & Maps
more
  • Sequence Map
    Chr17:85684277-85688274 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3998 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 55.72 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SIX2, SIX homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIX2, SIX homeobox 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 10736
    neXtProt AC: NX_Q9NPC8

  • Chr Location
    2p21; chr2:45005182-45009610 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56518
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SIX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 4 alleles in 4 genetic backgrounds
    34 phenotypes from multigenic genotypes
    10 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene die shortly after birth and exhibit abnormal kidney development. Abnormalities include small kidney, lack of ureteric bud branches throughout the kidney, increased apoptosis and premature and arrested nephron development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040063 VEGA Gene Model | MGI Sequence Detail 3998 C57BL/6J ±  kb
transcript OTTMUST00000104038 VEGA | MGI Sequence Detail 2119 Not Applicable  
polypeptide OTTMUSP00000058173 VEGA | MGI Sequence Detail 296 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    61 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 20
    cDNA 13
    Primer pair 3
    Other 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-19686
References
more
  • Summaries
    All 146
    Developmental Gene Expression 108
    Gene Ontology 20
    Phenotypes 22
  • Earliest
    J:23775 Oliver G, et al., Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
  • Latest
    J:231972 Takata N, et al., IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro. In Vitro Cell Dev Biol Anim. 2016 May;52(5):607-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory