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Six2
Gene Detail
 Symbol
Name
ID
Six2
sine oculis-related homeobox 2
MGI:102778
Feature Type protein coding gene
Genetic Map
Chromosome 17
55.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:85684277-85688274 bp, - strand
From VEGA annotation of GRCm38

  3998 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56518  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Six2

Human
homologs
Human Homolog SIX2, SIX homeobox 2
NCBI Gene ID 10736
neXtProt AC  NX_Q9NPC8
Human Chr (Location)  2p21; chr2:45005185-45009441 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene die shortly after birth and exhibit abnormal kidney development. Abnormalities include small kidney, lack of ureteric bud branches throughout the kidney, increased apoptosis and premature and arrested nephron development.
 
Phenotype Images(10)
Interactions
Six2 interacts with 92 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process canonical Wnt signaling pathway, cell proliferation, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (85 records)
Data Summary: Results (501)    Tissues (294)    Images (112)
Theiler Stages: 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 22
RNA in situ 452
Northern blot 1
Western blot 18
RT-PCR 8
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(13) Primer pair(3) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000040063 (Evidence)
Ensembl Gene ModelENSMUSG00000024134 (Evidence)
Entrez Gene20472 (Evidence)
UniGene5039
DFCITC1590264
DoTSDT.55164665, DT.87040511
NIA Mouse Gene IndexU038120
Consensus CDS ProjectCCDS29007.1
International Mouse Knockout Project StatusSix2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040063 VEGA Gene Model | MGI Sequence Detail 3998 C57BL/6J ±  kb
transcript OTTMUST00000104038 VEGA | MGI Sequence Detail 2119 Not Applicable 
polypeptide OTTMUSP00000058173 VEGA | MGI Sequence Detail 296 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000014897 homeobox protein SIX2
References (Earliest) J:23775 Oliver G, et al., Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
(Latest) J:208647 Xu J, et al., Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development. 2014 Apr;141(7):1442-52
All references(126)
Other
accession IDs
MGD-MRK-19686

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory