49 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdc42tm1Brak/Cdc42tm1Brak Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129 * C57BL/6J	abnormal kidney cortex morphology	J:195266
	abnormal kidney development	J:195266
	abnormal kidney papilla morphology	J:195266
	abnormal nephrogenic zone morphology	J:195266
	abnormal proximal convoluted tubule morphology	J:195266
	anuria	J:195266
	decreased renal glomerulus number	J:195266
	decreased renal tubule number	J:195266
	postnatal lethality, complete penetrance	J:195266
	renal hypoplasia	J:195266
Ctdnep1tm3Ryn/Ctdnep1tm3Ryn Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129X1/SvJ * C57BL/6 * C57BL/6J	decreased kidney apoptosis	J:205755
Ctdnep1tm3Ryn/Ctdnep1tm3Ryn Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129 * C57BL/6 * C57BL/6J	abnormal kidney morphology	J:205755
	abnormal nephron morphology	J:205755
	abnormal proximal convoluted tubule morphology	J:205755
	decreased kidney weight	J:205755
	premature death	J:205755
	renal glomerulus atrophy	J:205755
	small kidney	J:205755
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129S4/SvJaeSor * C57BL/6J	abnormal renal tubule morphology	J:185844
Gt(ROSA)26Sortm1(Sall1)Ryn/Gt(ROSA)26Sor+ Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129P2/OlaHsd * C57BL/6 * CD-1	no abnormal phenotype detected	J:162052
Gt(ROSA)26Sortm2(Notch2)Ryn/Gt(ROSA)26Sor+ Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129/Sv * 129P2/OlaHsd * C57BL/6J	abnormal kidney development	J:185844
	abnormal metanephric ureteric bud development	J:185844
	abnormal nephrogenic zone morphology	J:185844
	absent metanephric mesenchyme	J:185844
	dilated proximal convoluted tubule	J:185844
	dilated renal tubule	J:185844
	impaired branching involved in ureteric bud morphogenesis	J:185844
	neonatal lethality, complete penetrance	J:185844
	renal glomerulus cyst	J:185844
	small kidney	J:185844
Hnf4atm1Sad/Hnf4atm1Sad Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal kidney development	J:266356
	abnormal kidney morphology	J:266356
	abnormal proximal convoluted tubule morphology	J:266356
	increased urine glucose level	J:266356
	increased urine phosphate level	J:266356
	nephrocalcinosis	J:266356
	polydipsia	J:266356
	polyuria	J:266356
	small kidney	J:266356
Podxltm1Parl/Podxltm1Parl Podxl2tm1c(EUCOMM)Wtsi/Podxl2tm1c(EUCOMM)Wtsi Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	neonatal lethality, complete penetrance	J:240523
	normal renal/urinary system phenotype	J:240523
Six2tm1Gco/Six2tm1Gco Wnt9btm1.1Amc/Wnt9btm1.1Amc involves: 129/Sv * 129X1/SvJ * C57BL/6J	abnormal kidney development	J:148455
	delayed kidney development	J:148455
Six2tm1Gco/Six2tm1Gco Wnt9btm1.1Amc/Wnt9btm1.1Amc involves: 129X1/SvJ * C57BL/6J * NMRI	abnormal kidney development	J:148455
Srgap1tm1a(KOMP)Wtsi/Srgap1tm1a(KOMP)Wtsi Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129 * C57BL/6J * C57BL/6N	abnormal glomerular filtration barrier function	J:333727
	absent podocyte slit diaphragm	J:333727
	albuminuria	J:333727
	decreased podocyte number	J:333727
	detached podocyte	J:333727
	dilated renal tubule	J:333727
	expanded mesangial matrix	J:333727
	glomerulosclerosis	J:333727
	increased mesangial cell number	J:333727
	podocyte foot process effacement	J:333727
	renal cast	J:333727
Wasltm2Sbs/Wasltm2Sbs Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129 * C57BL/6J	decreased renal glomerulus number	J:195266
	decreased renal tubule number	J:195266
	renal hypoplasia	J:195266
Wwtr1tm1Hmc/Wwtr1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J	kidney cyst	J:195266
	kidney hemorrhage	J:195266
Wwtr1tm1Hmc/Wwtr1tm1Hmc Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl	abnormal kidney development	J:195266
	decreased renal glomerulus number	J:195266
	decreased renal tubule number	J:195266
	kidney cyst	J:195266
Yap1tm1Hmc/Yap1tm1Hmc Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl	abnormal kidney cortex morphology	J:195266
	abnormal kidney development	J:195266
	abnormal kidney medulla morphology	J:195266
	abnormal kidney papilla morphology	J:195266
	abnormal loop of Henle morphology	J:195266
	abnormal metanephros morphology	J:195266
	abnormal nephrogenic zone morphology	J:195266
	abnormal proximal convoluted tubule morphology	J:195266
	abnormal renal glomerulus morphology	J:195266
	abnormal renal tubule morphology	J:195266
	anuria	J:195266
	decreased renal glomerulus number	J:195266
	decreased renal tubule number	J:195266
	impaired branching involved in ureteric bud morphogenesis	J:195266
	podocyte foot process effacement	J:195266
	postnatal lethality, complete penetrance	J:195266
	renal hypoplasia	J:195266