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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Six2
sine oculis-related homeobox 2
MGI:102778
49 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Cdc42tm1Brak/\Cdc42tm1Brak
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129 * C57BL/6J 		abnormal kidney cortex morphology J:195266
abnormal kidney development J:195266
abnormal kidney papilla morphology J:195266
abnormal nephrogenic zone morphology J:195266
abnormal proximal convoluted tubule morphology J:195266
anuria J:195266
decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
postnatal lethality, complete penetrance J:195266
renal hypoplasia J:195266
\Ctdnep1tm3Ryn/\Ctdnep1tm3Ryn
\Gt(ROSA)26Sortm1(EYFP)Cos/\Gt(ROSA)26Sor+
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129X1/SvJ * C57BL/6 * C57BL/6J 		decreased kidney apoptosis J:205755
\Ctdnep1tm3Ryn/\Ctdnep1tm3Ryn
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129 * C57BL/6 * C57BL/6J 		abnormal kidney morphology J:205755
abnormal nephron morphology J:205755
abnormal proximal convoluted tubule morphology J:205755
decreased kidney weight J:205755
premature death J:205755
renal glomerulus atrophy J:205755
small kidney J:205755
\Gt(ROSA)26Sortm1(Notch1)Dam/\Gt(ROSA)26Sor+
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129S4/SvJaeSor * C57BL/6J 		abnormal renal tubule morphology J:185844
\Gt(ROSA)26Sortm1(Sall1)Ryn/\Gt(ROSA)26Sor+
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		no abnormal phenotype detected J:162052
\Gt(ROSA)26Sortm2(Notch2)Ryn/\Gt(ROSA)26Sor+
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J 		abnormal kidney development J:185844
abnormal metanephric ureteric bud development J:185844
abnormal nephrogenic zone morphology J:185844
absent metanephric mesenchyme J:185844
dilated proximal convoluted tubule J:185844
dilated renal tubule J:185844
impaired branching involved in ureteric bud morphogenesis J:185844
neonatal lethality, complete penetrance J:185844
renal glomerulus cyst J:185844
small kidney J:185844
\Hnf4atm1Sad/\Hnf4atm1Sad
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal kidney development J:266356
abnormal kidney morphology J:266356
abnormal proximal convoluted tubule morphology J:266356
increased urine glucose level J:266356
increased urine phosphate level J:266356
nephrocalcinosis J:266356
polydipsia J:266356
polyuria J:266356
small kidney J:266356
\Podxltm1Parl/\Podxltm1Parl
\Podxl2tm1c(EUCOMM)Wtsi/\Podxl2tm1c(EUCOMM)Wtsi
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		neonatal lethality, complete penetrance J:240523
normal renal/urinary system phenotype J:240523
\Six2tm1Gco/\Six2tm1Gco
\Wnt9btm1.1Amc/\Wnt9btm1.1Amc
involves: 129/Sv * 129X1/SvJ * C57BL/6J 		abnormal kidney development J:148455
delayed kidney development J:148455
\Six2tm1Gco/\Six2tm1Gco
\Wnt9btm1.1Amc/\Wnt9btm1.1Amc
involves: 129X1/SvJ * C57BL/6J * NMRI 		abnormal kidney development J:148455
\Srgap1tm1a(KOMP)Wtsi/\Srgap1tm1a(KOMP)Wtsi
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129 * C57BL/6J * C57BL/6N 		abnormal glomerular filtration barrier function J:333727
absent podocyte slit diaphragm J:333727
albuminuria J:333727
decreased podocyte number J:333727
detached podocyte J:333727
dilated renal tubule J:333727
expanded mesangial matrix J:333727
glomerulosclerosis J:333727
increased mesangial cell number J:333727
podocyte foot process effacement J:333727
renal cast J:333727
\Wasltm2Sbs/\Wasltm2Sbs
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129 * C57BL/6J 		decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
renal hypoplasia J:195266
\Wwtr1tm1Hmc/\Wwtr1tm1Hmc
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J 		kidney cyst J:195266
kidney hemorrhage J:195266
\Wwtr1tm1Hmc/\Wwtr1tm1Hmc
\Yap1tm1Hmc/\Yap1tm1Hmc
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl 		abnormal kidney development J:195266
decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
kidney cyst J:195266
\Yap1tm1Hmc/\Yap1tm1Hmc
\Six2tm1(tTA,tetO-EGFP/cre)Amc/\Six2+
involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl 		abnormal kidney cortex morphology J:195266
abnormal kidney development J:195266
abnormal kidney medulla morphology J:195266
abnormal kidney papilla morphology J:195266
abnormal loop of Henle morphology J:195266
abnormal metanephros morphology J:195266
abnormal nephrogenic zone morphology J:195266
abnormal proximal convoluted tubule morphology J:195266
abnormal renal glomerulus morphology J:195266
abnormal renal tubule morphology J:195266
anuria J:195266
decreased renal glomerulus number J:195266
decreased renal tubule number J:195266
impaired branching involved in ureteric bud morphogenesis J:195266
podocyte foot process effacement J:195266
postnatal lethality, complete penetrance J:195266
renal hypoplasia J:195266
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory