Six2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Six2
sine oculis-related homeobox 2
MGI:102778

17 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * C57BL/6J	no abnormal phenotype detected	J:148455
Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2^{tm1(tTA,tetO-EGFP/cre)Amc} involves: 129 * C57BL/6J	neonatal lethality, complete penetrance	J:148455
Six2^tm1Gco/Six2^tm1Gco involves: 129/Sv * 129X1/SvJ * C57BL/6J	abnormal kidney development	J:148455
Six2^tm1Gco/Six2^tm1Gco involves: 129X1/SvJ * C57BL/6J * NMRI	abnormal kidney development	J:148455
Six2^tm1Gco/Six2^tm1Gco Not Specified	abnormal kidney cortex morphology	J:115344
	abnormal kidney development	J:115344
	abnormal kidney morphology	J:115344
	abnormal nephron morphology	J:115344
	abnormal nephron number	J:115344
	impaired branching involved in ureteric bud morphogenesis	J:115344
	neonatal lethality, complete penetrance	J:115344
	renal hypoplasia	J:115344
	small kidney	J:115344
Six2^{tm2(cre/ERT2)Amc}/Six2⁺ involves: 129S4/SvJae * C57BL/6J	no abnormal phenotype detected	J:148455
Six2^{tm2(cre/ERT2)Amc}/Six2^{tm2(cre/ERT2)Amc} involves: 129S4/SvJae * C57BL/6J	neonatal lethality, complete penetrance	J:148455
Six2^{tm3(EGFP/cre/ERT2)Amc}/Six2⁺ involves: 129 * C57BL/6J	no abnormal phenotype detected	J:148455
Six2^{tm3(EGFP/cre/ERT2)Amc}/Six2^{tm3(EGFP/cre/ERT2)Amc} involves: 129 * C57BL/6J	neonatal lethality, complete penetrance	J:148455
Six2^{tm3(EGFP/cre/ERT2)Amc}/Six2^{tm3(EGFP/cre/ERT2)Amc} involves: 129/Sv * C57BL/6J	abnormal palatal mesenchymal cell proliferation	J:285711
	abnormal palatal shelf bone ossification	J:285711
	cleft palate	J:285711
	delayed palatal shelf elevation	J:285711
	domed cranium	J:285711
	neonatal lethality, complete penetrance	J:285711
	palatal shelves fail to meet at midline	J:285711
	short snout	J:285711

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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