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F2rl1
Gene Detail
Symbol

Name
ID
F2rl1
coagulation factor II (thrombin) receptor-like 1
MGI:101910
Synonyms
Gpcr11, Par2, PAR-2, Protease-activated receptor-2, proteinase-activated receptor-2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
49.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:95511732-95525240 bp, - strand
From Ensembl annotation of GRCm38

  13509 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21087  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: F2RL1
Protein SuperFamily: proteinase-activated receptor
Gene Tree: F2rl1

Human
homologs
F2RL1, coagulation factor II (thrombin) receptor-like 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2150
neXtProt AC: NX_P55085

Human Synonyms: GPR11, PAR2

Human Chr (Location): 5q13; chr5:76819008-76835315 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(25) Targeted(10) Transgenic(1)
Genomic Mutations involving F2rl1 (1)
Incidental mutations (data from APF , CvDC )
 
Nullizygous mice may exhibit impaired leukocyte rolling and dendritic cell maturation, altered inflammatory response in various models of acute and chronic inflammatory disease, altered susceptibility to injury and to autoimmune disorders, and abnormal hemodynamic responses and pain thresholds.
 
Mutations Annotated to Human Diseases (1)   
Interactions
F2rl1 interacts with 170 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (76 annotations)
Process blood coagulation, chemokine (C-C motif) ligand 2 secretion, ...
Component cytosol, early endosome, ...
Function G-protein alpha-subunit binding, G-protein beta-subunit binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (105)    Tissues (70)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 44
In situ reporter (knock in) 8
RT-PCR 50
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase f2rl1 ; ZFIN f2rl1.1, f2rl1.2    NEW 
Molecular
reagents
All nucleic(33) Genomic(6) cDNA(24) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021678 (Evidence)
Entrez Gene 14063 (Evidence)
UniGene 1614
DFCI TC1580643
DoTS DT.529605
NIA Mouse Gene Index U035055
Consensus CDS Project CCDS26700.1
International Mouse Phenotyping Consortium Status F2rl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021678 Ensembl Gene Model | MGI Sequence Detail 13509 C57BL/6J ±  kb
transcript ENSMUST00000022185 Ensembl | MGI Sequence Detail 2754 Not Applicable 
polypeptide ENSMUSP00000022185 Ensembl | MGI Sequence Detail 399 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(212 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR003912 Protease-activated receptor
InterPro IPR002281 Protease-activated receptor 2
Protein Ontology PR:000001662 proteinase-activated receptor 2
References
(Earliest) J:20517 Nystedt S, et al., Molecular cloning of a potential proteinase activated receptor [see comments]. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9208-12
(Latest) J:222109 Liang HP, et al., EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood. 2015 Apr 30;125(18):2845-54
All references(132)
Other
accession IDs
MGD-MRK-18739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory