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F2rl1 Gene Detail
Summary
  • Symbol
    F2rl1
  • Name
    coagulation factor II (thrombin) receptor-like 1
  • Synonyms
    Gpcr11, Par2, PAR-2, Protease-activated receptor-2, proteinase-activated receptor-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101910
    NCBI Gene: 14063
  • Gene Overview
    MyGene.info: F2RL1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:95511732-95525227 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13496 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 49.53 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    F2RL1, F2R like trypsin receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    F2RL1, F2R like trypsin receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPR11, PAR2
  • Links
    NCBI Gene ID: 2150
    neXtProt AC: NX_P55085
    UniProt: P55085

  • Chr Location
    5q13.3; chr5:76819008-76835315 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 6 alleles in 9 genetic backgrounds
    26 phenotypes from multigenic genotypes
    98 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice may exhibit impaired leukocyte rolling and dendritic cell maturation, altered inflammatory response in various models of acute and chronic inflammatory disease, altered susceptibility to injury and to autoimmune disorders, and abnormal hemodynamic responses and pain thresholds.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021678 Ensembl Gene Model | MGI Sequence Detail 13496 C57BL/6J ±  kb
    transcript ENSMUST00000022185 Ensembl | MGI Sequence Detail 2741 Not Applicable  
    polypeptide ENSMUSP00000022185 Ensembl | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      207 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 6
      cDNA 24
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18739
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 11
      Phenotypes 98
    • Earliest
      J:20517 Nystedt S, et al., Molecular cloning of a potential proteinase activated receptor [see comments]. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9208-12
    • Latest
      J:260414 Francis N, et al., A T cell-specific knockout reveals an important role for protease-activated receptor 2 in lymphocyte development. Int J Biochem Cell Biol. 2017 Nov;92:95-103

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory