F2rl1
Gene Detail

Symbol Name ID

F2rl1 coagulation factor II (thrombin) receptor-like 1 MGI:101910

Synonyms

Gpcr11, Par2, PAR-2, Protease-activated receptor-2, proteinase-activated receptor-2

Feature Type

protein coding gene

Genetic Map

Chromosome 13

49.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:95511732-95525240 bp, - strand From Ensembl annotation of GRCm38   13509 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21087  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: proteinase-activated receptor
Gene Tree: F2rl1

Human homologs

Human Homolog		F2RL1, coagulation factor II (thrombin) receptor-like 1
NCBI Gene ID		2150
neXtProt AC		NX_P55085
Human Synonyms		GPR11, PAR2
Human Chr (Location)		5q13; chr5:76114833-76131140 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(34) : Targeted(9) Gene trapped(25)
 

Nullizygous mice may exhibit impaired leukocyte rolling and dendritic cell maturation, altered inflammatory response in various models of acute and chronic inflammatory disease, altered susceptibility to injury and to autoimmune disorders, and abnormal hemodynamic responses and pain thresholds.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (72 annotations)

Process	blood coagulation, chemokine (C-C motif) ligand 2 secretion, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	G-protein alpha-subunit binding, G-protein beta-subunit binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (105)    Tissues (72)    Images (13)
Theiler Stages: 14, 15, 19, 23, 25, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	44
In situ reporter (knock in)	8
RT-PCR	50

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(6) cDNA(22) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021678 (Evidence)
Entrez Gene	14063 (Evidence)
UniGene	1614
DFCI	TC1580643
DoTS	DT.529605
NIA Mouse Gene Index	U035055
Consensus CDS Project	CCDS26700.1
International Mouse Knockout Project Status	F2rl1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021678	Ensembl Gene Model | MGI Sequence Detail	13509	C57BL/6J
transcript	ENSMUST00000022185	Ensembl | MGI Sequence Detail	2754	Not Applicable
polypeptide	ENSMUSP00000022185	Ensembl | MGI Sequence Detail	399	Not Applicable

All sequences(23) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(155 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR003912	Protease-activated receptor
InterPro	IPR002281	Protease-activated receptor 2
Protein Ontology	PR:000001662	proteinase-activated receptor 2

References

(Earliest) J:20517 Nystedt S, et al., Molecular cloning of a potential proteinase activated receptor [see comments]. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9208-12
(Latest) J:192750 Akiyama T, et al., Cross-sensitization of histamine-independent itch in mouse primary sensory neurons. Neuroscience. 2012 Dec 13;226:305-12
All references(116)

Other accession IDs

MGD-MRK-18739