Excel File Text File All mouse models of congenital heart disease with phenotypic similarity to the human disease
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
      atrial heart septal defect 2 Gata4tm1Grg/Gata4+ involves: 129 * C57BL/6 J:185124 View
atrial heart septal defect 7 Nkx2-5tm2.1Mwc/Nkx2-5+ B6J.Cg-Nkx2-5tm2.1Mwc/Mwc J:239808 View
atrial heart septal defect 7 Nkx2-5tm3.1Mwc/Nkx2-5+ B6J.Cg-Nkx2-5tm3.1Mwc/Mwc J:239808 View
Char syndrome Tfap2btm1Rbu/Tfap2btm1Rbu involves: 129S1/Sv * 129X1/SvJ J:175832 View
hypoplastic left heart syndrome Nkx2-5tm2.1Mwc/Nkx2-5+ B6J.Cg-Nkx2-5tm2.1Mwc/Mwc J:239808 View
hypoplastic left heart syndrome Nkx2-5tm3.1Mwc/Nkx2-5+ B6J.Cg-Nkx2-5tm3.1Mwc/Mwc J:239808 View
tetralogy of Fallot Nkx2-5tm2.1Mwc/Nkx2-5+ B6J.Cg-Nkx2-5tm2.1Mwc/Mwc J:239808 View
tetralogy of Fallot Nkx2-5tm3.1Mwc/Nkx2-5+ B6J.Cg-Nkx2-5tm3.1Mwc/Mwc J:239808 View
tetralogy of Fallot Zfpm2tm1Sho/Zfpm2tm1Sho involves: 129S1/Sv J:62879, J:78688 View
      atrial heart septal defect 1 pta/pta C57BL/6J-pta J:94456 View
atrial heart septal defect 1 Ntf3tm1Par/Ntf3tm1Par involves: 129S1/Sv J:35639 View
atrial heart septal defect 1 Ccn1tm1Lfl/Ccn1+ involves: 129S4/SvJae * C57BL/6J J:126490 View
atrial heart septal defect 1 avc2/avc2 involves: C57BL/6J * FVB/N J:163196 View
atrioventricular septal defect Nr1d2tm1Dgen/Nr1d2tm1Dgen B6;129P2-Nr1d2tm1Dgen/H J:232480 View
atrioventricular septal defect pta/pta C57BL/6J-pta J:94456 View
atrioventricular septal defect Gata4tm1.1Sad/Gata4+
Glyr1em1Dsr/Glyr1+
Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL J:322763 View
atrioventricular septal defect Ccn1tm1Lfl/Ccn1tm1Lfl involves: 129S4/SvJae * C57BL/6J J:126490 View
atrioventricular septal defect Bmp4tm3.1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * ICR J:86001 View
atrioventricular septal defect Bmp4tm1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR J:86001 View
atrioventricular septal defect Glyr1em1Dsr/Glyr1em1Dsr involves: C57BL/6J J:322763 View
atrioventricular septal defect l11Jus16/l11Jus16 involves: C57BL/6J * FVB/N J:163196 View
atrioventricular septal defect Ift172avc1/Ift172avc1 involves: C57BL/6J * FVB/N J:163196 View
atrioventricular septal defect avc3/avc3 involves: C57BL/6J * FVB/N J:163196 View
atrioventricular septal defect Dnah11avc4/Dnah11avc4 involves: C57BL/6J * FVB/N J:163196 View
atrioventricular septal defect Mks1avc6/Mks1avc6 involves: C57BL/6J * FVB/N J:163196 View
congenital heart disease Nkx2-5tm1.1Hkas/Nkx2-5+ 129S2.Cg-Nkx2-5tm1.1Hkas J:273096, J:273097 View
congenital heart disease b2b243.1Clo/b2b243.1Clo C57BL/6J-b2b243.1Clo J:175213 View
congenital heart disease b2b243Clo/b2b243Clo C57BL/6J-b2b243Clo J:175213 View
congenital heart disease b2b520Clo/b2b520Clo C57BL/6J-b2b520Clo J:175213 View
congenital heart disease b2b913Clo/b2b913Clo C57BL/6J-b2b913Clo J:175213 View
congenital heart disease b2b1639Clo/b2b1639Clo C57BL/6J-b2b1639Clo J:175213 View
congenital heart disease Sap130b2b635.2Clo/Sap130b2b635.2Clo C57BL/6J-Sap130b2b635.2Clo J:242757 View
congenital heart disease Sap130b2b635.2Clo/Sap130b2b635.2Clo C57BL/6J-Sap130b2b635.2Clo Pcdha9b2b635.1Clo J:242757 View
congenital heart disease Nkx2-5tm1.1Burg/Nkx2-5+ involves: 129S1/Sv * 129S2/SvPasCrl * 129X1/SvJ J:251389 View
congenital heart disease Rxratm1Rev/Rxra+ involves: 129S4/SvJae * C57BL/6 J:35363 View
dextro-looped transposition of the great arteries Dvl2tm1Awb/Dvl2tm1Awb either: 129S6/SvEvTac-Dvl2tm1Awb or (involves: 129S6/SvEvTac * NIH Swiss) J:96661 View
dextro-looped transposition of the great arteries Hspg2tm1Ref/Hspg2tm1Ref involves: 129S1/Sv * 129X1/SvJ J:80720, J:107987 View
dextro-looped transposition of the great arteries Cfc1tm1Cbm/Cfc1tm1Cbm Not Specified J:58530 View
double outlet right ventricle Ece1tm1Reh/Ece1tm1Reh involves: 129S6/SvEvTac * C57BL/6J J:62261 View
double outlet right ventricle Ece1tm1Reh/Ece1tm1Reh
Ece2tm1Ywa/Ece2tm1Ywa
involves: 129S6/SvEvTac * C57BL/6J J:62261 View
double outlet right ventricle Cfc1tm1Cbm/Cfc1tm1Cbm Not Specified J:58530 View
hypoplastic left heart syndrome b2b464Clo/b2b464Clo C57BL/6J-b2b464Clo J:175213 View
hypoplastic left heart syndrome b2b635Clo/b2b635Clo C57BL/6J-b2b635Clo J:175213 View
hypoplastic left heart syndrome b2b1430Clo/b2b1430Clo C57BL/6J-b2b1430Clo J:175213 View
hypoplastic left heart syndrome b2b1432Clo/b2b1432Clo C57BL/6J-b2b1432Clo J:175213 View
hypoplastic left heart syndrome b2b1709Clo/b2b1709Clo C57BL/6J-b2b1709Clo J:175213 View
hypoplastic left heart syndrome b2b1963Clo/b2b1963Clo C57BL/6J-b2b1963Clo J:175213 View
hypoplastic left heart syndrome b2b3077.2Clo/b2b3077.2Clo C57BL/6J-b2b3077.2Clo J:175213 View
hypoplastic left heart syndrome b2b3077Clo/b2b3077Clo C57BL/6J-b2b3077Clo J:175213 View
hypoplastic left heart syndrome b2b3183Clo/b2b3183Clo C57BL/6J-b2b3183Clo J:175213 View
hypoplastic left heart syndrome Sap130b2b635.2Clo/Sap130b2b635.2Clo C57BL/6J-Sap130b2b635.2Clo Pcdha9b2b635.1Clo J:242757 View
hypoplastic left heart syndrome Pcdha9em1Clo/Pcdha9em1Clo
Sap130em1Clo/Sap130em1Clo
C57BL/6J-Sap130em1Clo Pcdha9em1Clo/MurrJ J:242757 View
patent ductus arteriosus Myocdtm1Msp/Myocdtm1Msp
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129/Sv * C57BL/6 * CBA J:131288 View
patent ductus arteriosus Myocdtm1Msp/Myocdtm1Msp
Tg(Pax3-cre)1Joe/0
involves: 129/Sv * C57BL/6 * SJL J:131288 View
patent ductus arteriosus Tfap2bem1Fenli/Tfap2bem1Fenli involves: C57BL/6 J:278067 View
tetralogy of Fallot Bmp10b2b2711Clo/Bmp10b2b2711Clo C57BL/6J-Bmp10b2b2711Clo J:175213 View
tetralogy of Fallot Dock1b2b3190Clo/Dock1b2b3190Clo C57BL/6J-Dock1b2b3190Clo J:175213 View
tetralogy of Fallot Hey2tm1Uts/Hey2tm1Uts either: (involves: 129X1/SvJ) or (involves: C57BL/6) J:79025 View
tetralogy of Fallot Invsinv/Invsinv FVB/N-Invsinv J:48533 View
tetralogy of Fallot Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Tg(Msx2-cre)5Rem/0
involves: 129P2/OlaHsd J:66266 View
tetralogy of Fallot Ntf3tm1Par/Ntf3tm1Par involves: 129S1/Sv J:35639 View
tetralogy of Fallot Phc1tm1Os/Phc1tm1Os involves: 129S2/SvPas * C57BL/6 J:43764 View
tetralogy of Fallot Gja5tm1Paul/Gja5tm1Paul involves: 129S4/SvJae * C57BL/6 J:109301 View
tetralogy of Fallot Gja5tm1Paul/Gja5+ involves: 129S4/SvJae * C57BL/6 J:109301 View
tetralogy of Fallot Cited2tm1Ycy/Cited2tm1Ycy involves: C57BL/6J J:78364 View
tetralogy of Fallot Dnah5hlb612/Dnah5hlb612 involves: C57BL/6J J:130755 View
tetralogy of Fallot Mks1avc6/Mks1avc6 involves: C57BL/6J * FVB/N J:163196 View
Transgenes and
Other Mutations
     dextro-looped transposition of the great arteries Del(11Mpo-Chad)18Brd/+ involves: 129S7/SvEvBrd * C57BL/6 J:109163 View
tetralogy of Fallot Del(11Mpo-Chad)18Brd/+ involves: 129S7/SvEvBrd * C57BL/6 J:109163 View
Additional
Complex
Models
     atrial heart septal defect 1 Nkx2-5tm4Rph/Nkx2-5+
Tbx20tm1.1Rph/Tbx20+
involves: 129S1/Sv * C57BL/6 J:98489 View
tetralogy of Fallot Dp(16Lipi-Zbtb21)1Yey/0 involves: 129S7/SvEvBrd J:121790 View


       
No similarity to the expected human disease phenotype was found.
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
NOT Models      hypoplastic left heart syndrome Hand1tm5Abfi/Hand1+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd J:311466 View
hypoplastic left heart syndrome Hand1tm5Abfi/Hand1+
Tg(Myh6-cre)2182Mds/0
involves: FVB/N J:311466 View
hypoplastic left heart syndrome Hand1tm5Abfi/Hand1+
Tg(Mef2c-cre)2Blk/0
Not Specified J:311466 View