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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Lck-cre)1Jtak
transgene insertion 1, Junji Takeda
MGI:3655254
Summary 22 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Runx1tm1Yg/Runx1tm1Yg
Tg(Lck-cre)1Jtak/?
either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1) MGI:3760803
cn2
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(DO11.10)10Dlo/0
Tg(Lck-cre)1Jtak/0
involves: 129 * BALB/c * C3H * C57BL/6 MGI:4818271
cn3
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraTcrb)425Cbn/0
involves: 129 * BALB/c * C57BL/6 MGI:5805811
cn4
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
involves: 129 * C57BL/6 MGI:5805806
cn5
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
involves: 129 * C57BL/6 MGI:4818270
cn6
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraTcrb)1100Mjb/0
involves: 129 * C57BL/6 MGI:5805812
cn7
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Tg(Lck-cre)1Jtak/0
involves: 129 * C57BL/6 MGI:5805804
cn8
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
involves: 129 * C57BL/6 MGI:5805805
cn9
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129 * C57BL/6 * C57BL/6J * DBA/2J MGI:4818273
cn10
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129 * C57BL/6 * C57BL/6J * DBA/2J MGI:5805813
cn11
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(BCL2)25Wehi/0
Tg(Lck-cre)1Jtak/0
involves: 129 * C57BL/6 * C57BL/6JWehi * SJL/JWehi MGI:5805810
cn12
Stat3tm2Aki/Stat3tm2Aki
Tg(Lck-cre)1Jtak/0
involves: 129P2/OlaHsd MGI:3770250
cn13
Cxcr4tm1Yiw/Cxcr4tm1Yiw
Tg(Lck-cre)1Jtak/0
involves: 129P2/OlaHsd MGI:4836916
cn14
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Lck-cre)1Jtak/0
involves: 129P2/OlaHsd MGI:3664612
cn15
Cd19tm1(cre)Cgn/Cd19+
Ltbtm1Avt/Ltbtm1Avt
Tg(Lck-cre)1Jtak/?
involves: 129P2/OlaHsd * C57BL/6 MGI:3768341
cn16
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Lck-cre)1Jtak/0
involves: 129S1/Sv * 129X1/SvJ MGI:3698301
cn17
Socs1tm1Ayos/Socs1tm1Ayos
Tg(Lck-cre)1Jtak/0
involves: 129S4/SvJae * C57BL/6 MGI:3783712
cn18
Bcl11btm2Jpk/Bcl11b+
Tg(Lck-cre)1Jtak/0
involves: C57BL/6 MGI:5571296
cn19
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
Tg(Lck-cre)1Jtak/?
involves: C57BL/6 MGI:5501490
cn20
Map3k3tm1Kuro/Map3k3tm1Kuro
Tg(Lck-cre)1Jtak/0
involves: C57BL/6 MGI:3840864
cn21
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Tg(Lck-cre)1Jtak/0
Not Specified MGI:5547378
cx22
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Lck-cre)1Jtak/0
involves: 129P2/OlaHsd * C57BL/6 MGI:5823990


Genotype
MGI:3760803
cn1
Allelic
Composition
Runx1tm1Yg/Runx1tm1Yg
Tg(Lck-cre)1Jtak/?
Genetic
Background
either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Yg mutation (2 available); any Runx1 mutation (12 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• despite normal thymus development and a complete rescue of embryonic lethality, mice display a reduction in the number of Runx1+ T cells

hematopoietic system
• despite normal thymus development and a complete rescue of embryonic lethality, mice display a reduction in the number of Runx1+ T cells




Genotype
MGI:4818271
cn2
Allelic
Composition
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(DO11.10)10Dlo/0
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129 * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1.1Hua mutation (0 available); any Grb2 mutation (34 available)
Tg(DO11.10)10Dlo mutation (6 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• positive selection of CD4+ cells is severely impaired compared to in DO11.10 TCR control mice

hematopoietic system
• positive selection of CD4+ cells is severely impaired compared to in DO11.10 TCR control mice




Genotype
MGI:5805811
cn3
Allelic
Composition
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraTcrb)425Cbn/0
Genetic
Background
involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (0 available); any Prkd2 mutation (20 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (42 available)
Tg(Lck-cre)1Jtak mutation (3 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD4+ or CD8+ single positive thymocytes
• reduced CD4+CD8int intermediate cells

endocrine/exocrine glands
• CD4+ or CD8+ single positive thymocytes
• reduced CD4+CD8int intermediate cells

hematopoietic system
• CD4+ or CD8+ single positive thymocytes
• reduced CD4+CD8int intermediate cells




Genotype
MGI:5805806
cn4
Allelic
Composition
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (0 available); any Prkd2 mutation (20 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (42 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• small and fragmented
• reduced CD4+ single positive thymocytes
• reduced CD4+CD8int intermediate cells

endocrine/exocrine glands
• small and fragmented
• reduced CD4+ single positive thymocytes
• reduced CD4+CD8int intermediate cells

hematopoietic system
• small and fragmented
• reduced CD4+ single positive thymocytes
• reduced CD4+CD8int intermediate cells




Genotype
MGI:4818270
cn5
Allelic
Composition
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1.1Hua mutation (0 available); any Grb2 mutation (34 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• slightly in the thymus and lymph nodes
• maturation of double positive thymocytes to single positive thymocytes is impaired compared to in wild-type mice
• mice exhibit a marked decrease in CD4+ T cells in the thymus compared with wild-type mice
• peripheral CD4+ T cells in the spleen and lymph node are decreased compared to in wild-type mice
• mice exhibit a moderate decrease in CD8+ T cells in the thymus compared with wild-type mice
• peripheral CD8+ T cells in the spleen and lymph node are decreased compared to in wild-type mice

hematopoietic system
• slightly in the thymus and lymph nodes
• maturation of double positive thymocytes to single positive thymocytes is impaired compared to in wild-type mice
• mice exhibit a marked decrease in CD4+ T cells in the thymus compared with wild-type mice
• peripheral CD4+ T cells in the spleen and lymph node are decreased compared to in wild-type mice
• mice exhibit a moderate decrease in CD8+ T cells in the thymus compared with wild-type mice
• peripheral CD8+ T cells in the spleen and lymph node are decreased compared to in wild-type mice

endocrine/exocrine glands
• slightly in the thymus and lymph nodes




Genotype
MGI:5805812
cn6
Allelic
Composition
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (0 available); any Prkd2 mutation (20 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (42 available)
Tg(Lck-cre)1Jtak mutation (3 available)
Tg(TcraTcrb)1100Mjb mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• reduced CD4+CD8int intermediate cells

endocrine/exocrine glands
• reduced CD4+CD8int intermediate cells

hematopoietic system
• reduced CD4+CD8int intermediate cells




Genotype
MGI:5805804
cn7
Allelic
Composition
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (0 available); any Prkd2 mutation (20 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal Cd4+ single positive thymocytes




Genotype
MGI:5805805
cn8
Allelic
Composition
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (42 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed




Genotype
MGI:4818273
cn9
Allelic
Composition
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1.1Hua mutation (0 available); any Grb2 mutation (34 available)
Tg(Lck-cre)1Jtak mutation (3 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• positive selection of CD8+ cells in female mice is impaired compared to in H-Y TCR control mice
• male mice fail to exhibit negative selection of double positive and CD8+ T cells unlike H-Y TCR control mice
• Staphylococcal enterotoxin B (SEB)-treated mice fail to exhibit a decrease in TCR Vbeta8+ thymocytes unlike similarly treated H-Y TCR control mice

hematopoietic system
• positive selection of CD8+ cells in female mice is impaired compared to in H-Y TCR control mice
• male mice fail to exhibit negative selection of double positive and CD8+ T cells unlike H-Y TCR control mice
• Staphylococcal enterotoxin B (SEB)-treated mice fail to exhibit a decrease in TCR Vbeta8+ thymocytes unlike similarly treated H-Y TCR control mice




Genotype
MGI:5805813
cn10
Allelic
Composition
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(Lck-cre)1Jtak/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (0 available); any Prkd2 mutation (20 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (42 available)
Tg(Lck-cre)1Jtak mutation (3 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD8+ single positive thymocytes

endocrine/exocrine glands
• CD8+ single positive thymocytes

hematopoietic system
• CD8+ single positive thymocytes




Genotype
MGI:5805810
cn11
Allelic
Composition
Prkd2tm1.1Shoy/Prkd2tm1.1Shoy
Prkd3tm1.1Shoy/Prkd3tm1.1Shoy
Tg(BCL2)25Wehi/0
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkd2tm1.1Shoy mutation (0 available); any Prkd2 mutation (20 available)
Prkd3tm1.1Shoy mutation (0 available); any Prkd3 mutation (42 available)
Tg(BCL2)25Wehi mutation (1 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD4+ single positive thymocytes

endocrine/exocrine glands
• CD4+ single positive thymocytes

hematopoietic system
• CD4+ single positive thymocytes




Genotype
MGI:3770250
cn12
Allelic
Composition
Stat3tm2Aki/Stat3tm2Aki
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm2Aki mutation (1 available); any Stat3 mutation (36 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T cells fail to exhibit an anti-apoptotic effect in response to IL-6 unlike in wild-type mice
• proliferate in response to IL-6 plus anti-CD3, IL-2 or IL-6 plus ConA stimulation in decreased or absent unlike wild-type mice
• however, proliferation in response to IL-7 is normal

hematopoietic system
• T cells fail to exhibit an anti-apoptotic effect in response to IL-6 unlike in wild-type mice
• proliferate in response to IL-6 plus anti-CD3, IL-2 or IL-6 plus ConA stimulation in decreased or absent unlike wild-type mice
• however, proliferation in response to IL-7 is normal

cellular
• T cells fail to exhibit an anti-apoptotic effect in response to IL-6 unlike in wild-type mice
• proliferate in response to IL-6 plus anti-CD3, IL-2 or IL-6 plus ConA stimulation in decreased or absent unlike wild-type mice
• however, proliferation in response to IL-7 is normal




Genotype
MGI:4836916
cn13
Allelic
Composition
Cxcr4tm1Yiw/Cxcr4tm1Yiw
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm1Yiw mutation (3 available); any Cxcr4 mutation (10 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers
• thymocytes numbers are significantly reduced

immune system
• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers
• thymocytes numbers are significantly reduced
• the incidence, but not the severity, of collagen induced arthritis is significantly reduced

skeleton
• the incidence, but not the severity, of collagen induced arthritis is significantly reduced

cellular
• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers

endocrine/exocrine glands
• thymocytes numbers are significantly reduced




Genotype
MGI:3664612
cn14
Allelic
Composition
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7tm1Aki mutation (0 available); any Map3k7 mutation (34 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• at 4 - 6 months of age, loss of goblet cells is seen in the large intestine but not in the small intestine
• impaired proliferation in response to anti-CD3 stimulation with or without co-stimulation by anti-CD28

immune system
• with mononuclear cell infiltration of the colon seen at 4 - 6 months of age
• in older mice numbers of activated/memory T cells increases; however, these cells contain only unrecombined alleles
• markedly reduced numbers of peripheral T cells
• at 4 - 6 months of age almost no naive T cells are found in the spleen and lymph nodes
• severe decrease in the number of CD24low mature cells while the number of CD24high immature cells is similar to controls
• severe decrease in the number of CD24low mature cells while the number of CD24high immature cells is similar to controls
• no detectable regulatory T cells in the thymus or spleen at 6 weeks of age
• decreased numbers of single positive T cells, especially CD8+ cells, while the numbers of double negative and double positive T cells is similar to controls
• seen at 4 - 6 months of age
• increase in the numbers of myeloid lineage cells (macrophages, neutrophils) but almost a complete absence of naive T cells is detected at 4 - 6 months of age
• dose-dependent induction of cell death in response to TNF stimulation unlike controls cells which are viable after TNF stimulation
• impaired proliferation in response to anti-CD3 stimulation with or without co-stimulation by anti-CD28
• seen at 4 - 6 months of age

digestive/alimentary system
• at 4 - 6 months of age, loss of goblet cells is seen in the large intestine but not in the small intestine
• prominent ulceration is seen at 4 - 6 months of age in the large, but not the small, intestine
• stiff colon present at 4 - 6 months of age
• seen at 4 - 6 months of age
• severe diarrhea beginning at 4 - 6 months of age
• with mononuclear cell infiltration of the colon seen at 4 - 6 months of age

growth/size/body
• begins at 4 - 6 months of age

hematopoietic system
• in older mice numbers of activated/memory T cells increases; however, these cells contain only unrecombined alleles
• markedly reduced numbers of peripheral T cells
• at 4 - 6 months of age almost no naive T cells are found in the spleen and lymph nodes
• severe decrease in the number of CD24low mature cells while the number of CD24high immature cells is similar to controls
• severe decrease in the number of CD24low mature cells while the number of CD24high immature cells is similar to controls
• no detectable regulatory T cells in the thymus or spleen at 6 weeks of age
• decreased numbers of single positive T cells, especially CD8+ cells, while the numbers of double negative and double positive T cells is similar to controls
• seen at 4 - 6 months of age
• increase in the numbers of myeloid lineage cells (macrophages, neutrophils) but almost a complete absence of naive T cells is detected at 4 - 6 months of age
• dose-dependent induction of cell death in response to TNF stimulation unlike controls cells which are viable after TNF stimulation
• impaired proliferation in response to anti-CD3 stimulation with or without co-stimulation by anti-CD28




Genotype
MGI:3768341
cn15
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Ltbtm1Avt/Ltbtm1Avt
Tg(Lck-cre)1Jtak/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (8 available); any Cd19 mutation (16 available)
Ltbtm1Avt mutation (0 available); any Ltb mutation (12 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice lack follicular dendritic cells and no immune complex binding is observed




Genotype
MGI:3698301
cn16
Allelic
Composition
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1atm3Rsjo mutation (3 available); any Hif1a mutation (11 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• exhibit higher IFN-gamma secretion by activated splenocytes
• both CD4+ and CD8+ T cells produce higher levels or IFN-gamma upon activation




Genotype
MGI:3783712
cn17
Allelic
Composition
Socs1tm1Ayos/Socs1tm1Ayos
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Ayos mutation (1 available); any Socs1 mutation (21 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• IL-17 producing CD4+ T cells differentiated in vitro and induced with IL-6 and TGF-beta with the anti-TCR antibody results in stronger induction of IFN-gamma producing cells and a marked reduction of IL-17 producing cells in contrast to similarly treated wild-type cells
• CD4+ T cells preferentially differentiate into Th1 cells and not Th17 unlike wild-type cells
• CD4+ T cells are resistant to the suppressive effects of TGF-beta on IGN-gamma production unlike wild-type cells
• mice are less susceptible to experimental autoimmune encephalomyelitis (EAE) and produce less IL-17 following EAE compared to wild-type mice

hematopoietic system
• IL-17 producing CD4+ T cells differentiated in vitro and induced with IL-6 and TGF-beta with the anti-TCR antibody results in stronger induction of IFN-gamma producing cells and a marked reduction of IL-17 producing cells in contrast to similarly treated wild-type cells
• CD4+ T cells preferentially differentiate into Th1 cells and not Th17 unlike wild-type cells
• CD4+ T cells are resistant to the suppressive effects of TGF-beta on IGN-gamma production unlike wild-type cells




Genotype
MGI:5571296
cn18
Allelic
Composition
Bcl11btm2Jpk/Bcl11b+
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11btm2Jpk mutation (0 available); any Bcl11b mutation (10 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased percentage of immature single positive cells in irradiated mice
• in irradiated mice
• increased percentage in irradiated mice
• decreased percent in irradiated mice
• decreased percent in irradiated mice
• decreased percent in irradiated mice

neoplasm
• thymic lymphomas in 4 of 5 irradiated mice

cellular
• attenuated radiation-induced cell cycle arrest at the S phase in immature single positive cells of irradiated mice

endocrine/exocrine glands
• in irradiated mice

hematopoietic system
• increased percentage of immature single positive cells in irradiated mice
• in irradiated mice
• increased percentage in irradiated mice
• decreased percent in irradiated mice
• decreased percent in irradiated mice
• decreased percent in irradiated mice




Genotype
MGI:5501490
cn19
Allelic
Composition
Nfkbiztm1.1Muta/Nfkbiztm1.1Muta
Tg(Lck-cre)1Jtak/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiztm1.1Muta mutation (1 available); any Nfkbiz mutation (4 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• lack inflammation up to 30 weeks of age




Genotype
MGI:3840864
cn20
Allelic
Composition
Map3k3tm1Kuro/Map3k3tm1Kuro
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k3tm1Kuro mutation (0 available); any Map3k3 mutation (6 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• T cells exhibit decreased proliferation in response to anti-CD3 stimulation

immune system
• T cells exhibit decreased proliferation in response to anti-CD3 stimulation
• the number of thymoyctes is reduced by 40-60% compared to controls
• the percentage of double-negative thymocytes is about double that of control
• the percentage of double-positive thymocytes is reduced by 40-60%
• the number of CD4+ T cells in the spleen is reduced by about 50% compared to controls
• the number of CD8+ T cells in the spleen is reduced by about 60% compared to controls
• the percentage of single-positive thymocytes is reduced by 40-60%
• T cells secrete less IFN-gamma in response to anti-CD3 stimulation
• T cells secrete less IL-2 in response to anti-CD3 stimulation

hematopoietic system
• T cells exhibit decreased proliferation in response to anti-CD3 stimulation
• the number of thymoyctes is reduced by 40-60% compared to controls
• the percentage of double-negative thymocytes is about double that of control
• the percentage of double-positive thymocytes is reduced by 40-60%
• the number of CD4+ T cells in the spleen is reduced by about 50% compared to controls
• the number of CD8+ T cells in the spleen is reduced by about 60% compared to controls
• the percentage of single-positive thymocytes is reduced by 40-60%

endocrine/exocrine glands
• the number of thymoyctes is reduced by 40-60% compared to controls




Genotype
MGI:5547378
cn21
Allelic
Composition
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Tg(Lck-cre)1Jtak/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a2tm1.1Pcn mutation (0 available); any Nr4a2 mutation (25 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

immune system
N
• surviving mice exhibit no auto-immune disease symptoms up to 4 months of age
• mice exhibit normal numbers of regulatory T cells in the thymus and spleen
• DSS-treated mice exhibit accelerated body weight loss, severe intestinal inflammation, increased Th1 cells and attenuated increase of regulatory T cells in the colon and cecum lamina propria compared with control mice
• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions
• reduced under Th17-skewing conditions
• CD44highCD62Llow-activated and IFN-gamma CD4+ T cells
• in DSS-treated mice
• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions
• in DSS-treated mice

digestive/alimentary system
• DSS-treated mice exhibit accelerated body weight loss, severe intestinal inflammation, increased Th1 cells and attenuated increase of regulatory T cells in the colon and cecum lamina propria compared with control mice

growth/size/body
• accelerated in DSS-treated mice

hematopoietic system
• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions
• reduced under Th17-skewing conditions
• CD44highCD62Llow-activated and IFN-gamma CD4+ T cells
• in DSS-treated mice
• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions
• in DSS-treated mice




Genotype
MGI:5823990
cx22
Allelic
Composition
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Lck-cre)1Jtak/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7tm1Aki mutation (0 available); any Map3k7 mutation (34 available)
Tg(Lck-cre)1Jtak mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• increase in intestinal epithelial permeability indicating defective barrier function
• mice develop spontaneous colitis
• mice in which gut commensal bacteria is removed by treatment with four antibiotics do not exhibit colitis
• -6-8 week old mutants transferred with TCRalphabeta+CD8alpha+ IELS show significant amelioration of colitis, however transfer with CD8+ T or natural killer cells has no effect on colitis

hematopoietic system
• drastic reduction in the frequency and absolute number of TCR beta+ T cells in the mesenteric lymph nodes
• however, the colonic lamina propria contains TCR beta+ T cells
• some mice have up to 10 times more T cells in colonic lamina propria than wild-type mice
• the majority of TCR alpha beta+ T cells in the mesenteric lymph nodes and colonic lamina propria are CD4+ T cells compared to wild-type mice
• accumulation of CD4+ T cells in the colonic lamina propria
• the TCR beta+NK1.1+ natural killer T cell population in the thymus and liver and alpha-GalCer/CD1d-reacted natural killer T cell population in the liver are hardly detectable in mice
• reduction in the frequencies and absolute numbers of TCR beta+ intestinal intraepithelial lymphocytes (IEL) in both the small and large intestine
• both the CD8 alpha-alpha+ and CD8 alpha-beta+ cell populations of TCR beta+ IELs are almost completely absent
• the CD4+CD8 alpha-alpha+ cell population in TCR beta+CD8 beta- cells is decreased in the small and large intestine
• the colon exclusive TCR beta+CD4-CD8 alpha-CD8 beta- cell population is absent
• the remaining TCR beta+ IEL fraction is CD4+ T cells
• thymic IEL precursors (TCR alpha-beta+CD4-CD8-NK1.1-) are decreased in both frequency and absolute number; this reduction is due to almost complete loss of CD103+ cell population coexpressing both CD5 and CD122
• increase in the frequency of TCR gamma-delta+ IELs in the small and large intestines and the absolute numbers of these IELs are increased in the colon but not the small intestine
• frequency of regulatory T cells is higher in mesenteric lymph nodes and lower in colonic lamina propria in mice older than 10 weeks of age, however, absolute numbers of regulatory T cells are unchanged
• reduction in frequency of CD25+Foxp3+ cells in CD4 single positive thymocytes of 10 week old mice that do not have colitis
• thymic IEL precursors (TCRalphabeta+CD4-CD8-NK1.1-) stimulated with an agonistic anti-CD3 antibody in vitro do not show enlargement of cell size and induced expression of CD25, IL-2Ralpha chain as seen in wild-type cells
• thymic IEL precursors treated with the agonistic anti-CD3 antibody show inefficient induction of CD8alpha induction
• CD4+ T cells from colonic lamina propria and mesenteric lymph nodes stimulated with PMA plus ionomycin exhibit a more robust production of IFN-gamma and IL-17A than in wild-type cells
• in an in vitro suppression assay, regulatory T cells show less suppressive activity than wild-type T cells, indicating failure of suppressive function of the leaky regulatory T cells

homeostasis/metabolism
• colons show increased mRNA levels of proinflammatory cytokines and RegIII-beta/gamma proteins (antimicrobial peptides)
• elevation of expression of IFN-gamma and IL-17

immune system
• mice develop spontaneous colitis
• mice in which gut commensal bacteria is removed by treatment with four antibiotics do not exhibit colitis
• -6-8 week old mutants transferred with TCRalphabeta+CD8alpha+ IELS show significant amelioration of colitis, however transfer with CD8+ T or natural killer cells has no effect on colitis
• drastic reduction in the frequency and absolute number of TCR beta+ T cells in the mesenteric lymph nodes
• however, the colonic lamina propria contains TCR beta+ T cells
• some mice have up to 10 times more T cells in colonic lamina propria than wild-type mice
• the majority of TCR alpha beta+ T cells in the mesenteric lymph nodes and colonic lamina propria are CD4+ T cells compared to wild-type mice
• accumulation of CD4+ T cells in the colonic lamina propria
• the TCR beta+NK1.1+ natural killer T cell population in the thymus and liver and alpha-GalCer/CD1d-reacted natural killer T cell population in the liver are hardly detectable in mice
• reduction in the frequencies and absolute numbers of TCR beta+ intestinal intraepithelial lymphocytes (IEL) in both the small and large intestine
• both the CD8 alpha-alpha+ and CD8 alpha-beta+ cell populations of TCR beta+ IELs are almost completely absent
• the CD4+CD8 alpha-alpha+ cell population in TCR beta+CD8 beta- cells is decreased in the small and large intestine
• the colon exclusive TCR beta+CD4-CD8 alpha-CD8 beta- cell population is absent
• the remaining TCR beta+ IEL fraction is CD4+ T cells
• thymic IEL precursors (TCR alpha-beta+CD4-CD8-NK1.1-) are decreased in both frequency and absolute number; this reduction is due to almost complete loss of CD103+ cell population coexpressing both CD5 and CD122
• increase in the frequency of TCR gamma-delta+ IELs in the small and large intestines and the absolute numbers of these IELs are increased in the colon but not the small intestine
• frequency of regulatory T cells is higher in mesenteric lymph nodes and lower in colonic lamina propria in mice older than 10 weeks of age, however, absolute numbers of regulatory T cells are unchanged
• reduction in frequency of CD25+Foxp3+ cells in CD4 single positive thymocytes of 10 week old mice that do not have colitis
• thymic IEL precursors (TCRalphabeta+CD4-CD8-NK1.1-) stimulated with an agonistic anti-CD3 antibody in vitro do not show enlargement of cell size and induced expression of CD25, IL-2Ralpha chain as seen in wild-type cells
• thymic IEL precursors treated with the agonistic anti-CD3 antibody show inefficient induction of CD8alpha induction
• CD4+ T cells from colonic lamina propria and mesenteric lymph nodes stimulated with PMA plus ionomycin exhibit a more robust production of IFN-gamma and IL-17A than in wild-type cells
• in an in vitro suppression assay, regulatory T cells show less suppressive activity than wild-type T cells, indicating failure of suppressive function of the leaky regulatory T cells
• colons show increased mRNA levels of proinflammatory cytokines and RegIII-beta/gamma proteins (antimicrobial peptides)
• elevation of expression of IFN-gamma and IL-17
• CD4+ T cells from colonic lamina propria and mesenteric lymph nodes stimulated with PMA plus ionomycin exhibit a more robust production of IFN-gamma than in wild-type cells
• CD4+ T cells from colonic lamina propria and mesenteric lymph nodes stimulated with PMA plus ionomycin exhibit a more robust production of IL-17A than in wild-type cells

liver/biliary system
• large numbers of bacteria are detected in the livers





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/10/2019
MGI 6.14
The Jackson Laboratory