Grb2^tm1.1Hua
Targeted Allele Detail

Summary

• Symbol: Grb2^tm1.1Hua
• Name: growth factor receptor bound protein 2; targeted mutation 1.1, Hua Gu
• MGI ID: MGI:4462852
• Synonyms: Grb2^f
• Gene: Grb2 Location: Chr11:115534871-115599423 bp, - strand Genetic Position: Chr11, 80.91 cM
• Alliance: Grb2^tm1.1Hua page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161294
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A floxed neo cassette with a 5' loxP site was inserted upstream of exon 4 and an additional loxP site was inserted downstream of exon 4. Cre mediated recombination removed the neo cassette leaving exon 4 floxed. (J:161294)

Generation of the Grb2^tm1.1Hua allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grb2 Mutation: 42 strains or lines available

References

• Original: J:161294 Jang IK, et al., Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10620-5
• All: 4 reference(s)