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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(KRT14-cre)1Efu
transgene insertion 1, Elaine Fuchs
MGI:1926500
Summary 23 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Macf1tm1Efu/Macf1tm1Efu
Tg(KRT14-cre)1Efu/0
involves: 129 MGI:3829003
cn2
Dicer1tm1Tara/Dicer1tm1Tara
Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd MGI:5319528
cn3
Ago1tm1.1Tara/Ago1tm1.1Tara
Ago2tm1.1Tara/Ago2tm1.1Tara
Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd MGI:5319527
cn4
Ago2tm1.1Tara/Ago2tm1.1Tara
Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd MGI:5319525
cn5
Ctnnb1tm4Wbm/Ctnnb1+
Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd MGI:5435570
cn6
Ezh1tm1Jnw/Ezh1tm1Jnw
Ezh2tm1Tara/Ezh2tm1Tara
Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd MGI:4941024
cn7
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd MGI:4413472
cn8
Dicer1tm1Tara/Dicer1tm1Tara
Tg(KRT14-cre)1Efu/?
involves: 129P2/OlaHsd * CD-1 MGI:3625829
cn9
Cdh1tm2Kem/Cdh1tm2Kem
Tg(KRT14-cre)1Efu/0
Tg(Krt14-RNAi:Cdh3)1Efu/0
involves: 129S1/Sv * 129X1/SvJ MGI:3830547
cn10
Kdrtm1.1Jamb/Kdrtm1.1Jamb
Tg(KRT14-cre)1Efu/0
involves: 129S1/Sv * 129X1/SvJ * ICR MGI:4367771
cn11
Porcntm1.1Vdv/Y
Tg(KRT14-cre)1Efu/0
involves: 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6J MGI:5435568
cn12
Porcntm1.1Vdv/Porcn+
Tg(KRT14-cre)1Efu/0
involves: 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6J MGI:5435569
cn13
Dsptm1Efu/Dsptm1Efu
Tg(KRT14-cre)1Efu/0
involves: 129/Sv MGI:2652092
cn14
Tcf3tm1.1Efu/Tcf3tm1.1Efu
Tg(KRT14-cre)1Efu/0
involves: 129/Sv MGI:4413470
cn15
Tcf3tm1.1Efu/Tcf3tm1.1Efu
Tcf7l2tm1Cle/Tcf7l2tm1Cle
Tg(KRT14-cre)1Efu/0
involves: 129/Sv * 129P2/OlaHsd MGI:4413471
cn16
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(KRT14-cre)1Efu/?
involves: 129/Sv * C57BL/6J * SJL MGI:3714928
cn17
Itgb1tm1Efu/Itgb1tm1Efu
Tg(KRT14-cre)1Efu/0
involves: 129X1/SvJ MGI:2448680
cn18
Ctnna1tm1Efu/Ctnna1tm1Efu
Tg(KRT14-cre)1Efu/?
involves: 129X1/SvJ MGI:3720633
cn19
Atf2tm3Nicj/Atf2tm3Nicj
Tg(KRT14-cre)1Efu/?
involves: C57BL/6 * FVB/N MGI:3774840
cn20
Mir203tm1.1Yir/Mir203tm1.1Yir
Tg(KRT14-cre)1Efu/0
involves: C57BL/6 * SJL MGI:5698459
cn21
Ago1tm1.1Tara/Ago1tm1.1Tara
Tg(KRT14-cre)1Efu/0
Not Specified MGI:5319526
cn22
Casp8tm1Hed/Casp8tm1Hed
Tg(KRT14-cre)1Efu/0
Not Specified MGI:4888399
cx23
Ctnnd1tm1Abre/Ctnnd1tm1Abre
Tg(KRT14-cre)1Efu/?
involves: 129S6/SvEvTac MGI:3826503


Genotype
MGI:3829003
cn1
Allelic
Composition
Macf1tm1Efu/Macf1tm1Efu
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Macf1tm1Efu mutation (1 available); any Macf1 mutation (543 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• areas of hyperproliferating epithelium at wound sites are decreased by more than 30% over 2 to 4 days after injury compared to in similarly treated wild-type mice (J:143595)
• during an in vitro wound healing assay, keratinocyte move only 20% of the distance into the gap unlike wild-type cells (J:143595)
• areas of hyperproliferating epithelium at wound sites are decreased by more than 30% over 2 to 4 days after injury compared to in similarly treated wild-type mice (J:143595)
• during an in vitro wound healing assay, keratinocyte move only 20% of the distance into the gap unlike wild-type cells (J:143595)

integument
• keratinocytes exhibit stronger focal adhesions in culture than wild-type cells (J:143595)
• keratinocytes exhibit stronger focal adhesions in culture than wild-type cells (J:143595)
• during an in vitro wound healing assay, keratinocyte move only 20% of the distance into the gap unlike wild-type cells (J:143595)
• keratinocytes, in culture, exhibit a 60% decrease in average migration speed on fibronectin compared to wild-type cells (J:143595)
• rates of proliferation and apoptosis are normal, and reducing the underlying matrix protein in culture can restore migration speeds to normal (J:143595)
• during an in vitro wound healing assay, keratinocyte move only 20% of the distance into the gap unlike wild-type cells (J:143595)
• keratinocytes, in culture, exhibit a 60% decrease in average migration speed on fibronectin compared to wild-type cells (J:143595)
• rates of proliferation and apoptosis are normal, and reducing the underlying matrix protein in culture can restore migration speeds to normal (J:143595)

cellular
• during an in vitro wound healing assay, keratinocyte move only 20% of the distance into the gap unlike wild-type cells (J:143595)
• keratinocytes, in culture, exhibit a 60% decrease in average migration speed on fibronectin compared to wild-type cells (J:143595)
• rates of proliferation and apoptosis are normal, and reducing the underlying matrix protein in culture can restore migration speeds to normal (J:143595)
• during an in vitro wound healing assay, keratinocyte move only 20% of the distance into the gap unlike wild-type cells (J:143595)
• keratinocytes, in culture, exhibit a 60% decrease in average migration speed on fibronectin compared to wild-type cells (J:143595)
• rates of proliferation and apoptosis are normal, and reducing the underlying matrix protein in culture can restore migration speeds to normal (J:143595)




Genotype
MGI:5319528
cn2
Allelic
Composition
Dicer1tm1Tara/Dicer1tm1Tara
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1Tara mutation (1 available); any Dicer1 mutation (17 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• less developed hair coat at P4.5 (J:201587)
• less developed hair coat at P4.5 (J:201587)
• evaginating hair follicle cysts in the epidermis at P4 (J:183622)
• evaginating hair follicle cysts in the epidermis at P4 (J:183622)
• shortened and misangled hair follicle growth at P4 (J:183622)
• shortened and misangled hair follicle growth at P4 (J:183622)
• mice exhibit the loss of hair follicle stem cells in the bulge unlike in wild-type cells (J:201587)
• mice exhibit the loss of hair follicle stem cells in the bulge unlike in wild-type cells (J:201587)
• dehydrated at P4.5 (J:201587)
• dehydrated at P4.5 (J:201587)
• evaginating hair follicle cysts in the epidermis at P4 (J:183622)
• evaginating hair follicle cysts in the epidermis at P4 (J:183622)
• apoptotic cells in the basal epidermis (J:183622)
• apoptotic cells in the basal epidermis (J:183622)

growth/size/body
• at P4.5 (J:201587)
• at P4.5 (J:201587)




Genotype
MGI:5319527
cn3
Allelic
Composition
Ago1tm1.1Tara/Ago1tm1.1Tara
Ago2tm1.1Tara/Ago2tm1.1Tara
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ago1tm1.1Tara mutation (1 available); any Ago1 mutation (103 available)
Ago2tm1.1Tara mutation (1 available); any Ago2 mutation (16 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• evaginating hair follicle cysts in the epidermis at P4 (J:183622)
• evaginating hair follicle cysts in the epidermis at P4 (J:183622)
• shortened and misangled hair follicle growth at P4 (J:183622)
• shortened and misangled hair follicle growth at P4 (J:183622)
• hyperthickened (J:183622)
• hyperthickened (J:183622)
• evaginating hair follicle cysts in the epidermis at P4 (J:183622)
• evaginating hair follicle cysts in the epidermis at P4 (J:183622)
• apoptotic cells in the basal epidermis (J:183622)
• apoptotic cells in the basal epidermis (J:183622)




Genotype
MGI:5319525
cn4
Allelic
Composition
Ago2tm1.1Tara/Ago2tm1.1Tara
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ago2tm1.1Tara mutation (1 available); any Ago2 mutation (16 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no developmental defects are detected (J:183622)
• no developmental defects are detected (J:183622)




Genotype
MGI:5435570
cn5
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1+
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (0 available); any Ctnnb1 mutation (17 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lack of hair follicles in Ctnnb1tm4Wbm/Ctnnb1+ Tg(KRT14-cre)1Efu/0 mice

integument




Genotype
MGI:4941024
cn6
Allelic
Composition
Ezh1tm1Jnw/Ezh1tm1Jnw
Ezh2tm1Tara/Ezh2tm1Tara
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh1tm1Jnw mutation (0 available); any Ezh1 mutation (8 available)
Ezh2tm1Tara mutation (1 available); any Ezh2 mutation (26 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 24 hours of birth (J:169295)
• mice die within 24 hours of birth (J:169295)

integument
N
• mice do not exhibit skin inflammation (J:169295)
• mice do not exhibit skin inflammation (J:169295)
• hair follicles in skin grafts arrest in the first growth phase of the hair cycle (J:169295)
• skin grafts on nude mice remain hairless unlike wild-type grafts (J:169295)
• hair follicles in skin grafts arrest in the first growth phase of the hair cycle (J:169295)
• skin grafts on nude mice remain hairless unlike wild-type grafts (J:169295)
• skin grafts exhibit hyperproliferation in the infundibulum compared with wild-type cells (J:169295)
• skin grafts exhibit hyperproliferation in the infundibulum compared with wild-type cells (J:169295)
• hair follicle stem cells in the lower outer root sheath zone exhibit decreased proliferation compared with wild-type cells (J:169295)
• hair follicle stem cells in the lower outer root sheath zone exhibit decreased proliferation compared with wild-type cells (J:169295)
• hair follicle stem cells in the lower outer root sheath zone exhibit decreased proliferation regardless of stimulation compared with wild-type cells (J:169295)
• hair follicle cells exhibit increased apoptosis unlike wild-type cells (J:169295)
• hair follicle stem cells in the lower outer root sheath zone exhibit decreased proliferation regardless of stimulation compared with wild-type cells (J:169295)
• hair follicle cells exhibit increased apoptosis unlike wild-type cells (J:169295)
• hair follicles in skin grafts arrest in the first growth phase of the hair cycle (J:169295)
• hair follicles in skin grafts arrest in the first growth phase of the hair cycle (J:169295)

behavior/neurological




Genotype
MGI:4413472
cn7
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (0 available); any Ctnnb1 mutation (17 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die shortly after birth (J:155012)
• mice die shortly after birth (J:155012)

integument
• in newborns and when skin is grafted onto wild-type mice (J:155012)
• in newborns and when skin is grafted onto wild-type mice (J:155012)




Genotype
MGI:3625829
cn8
Allelic
Composition
Dicer1tm1Tara/Dicer1tm1Tara
Tg(KRT14-cre)1Efu/?
Genetic
Background
involves: 129P2/OlaHsd * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1Tara mutation (1 available); any Dicer1 mutation (17 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• began to lose weight within 1-2 day after birth, and died by day 6 (J:106792)
• mutant mice are normal at birth and continued to feed for several days (J:106792)
• began to lose weight within 1-2 day after birth, and died by day 6 (J:106792)
• mutant mice are normal at birth and continued to feed for several days (J:106792)

homeostasis/metabolism
• appeared dehydrated before death (J:106792)
• appeared dehydrated before death (J:106792)

cellular
• showed signs of apoptosis in skin as early as E17.5 (J:106792)
• frequency of apoptosis was higher in the hair germ (J:106792)
• at P6.5, apoptosis is enriched in hair follicles, including abnormal cysts in the epidermis (J:106792)
• showed signs of apoptosis in skin as early as E17.5 (J:106792)
• frequency of apoptosis was higher in the hair germ (J:106792)
• at P6.5, apoptosis is enriched in hair follicles, including abnormal cysts in the epidermis (J:106792)

integument
• hair germs appear to evaginate into the epidermis (J:106792)
• hair germ-like cysts became prevalent, markedly distorting the overlying epidermis (J:106792)
• hair germs appear to evaginate into the epidermis (J:106792)
• hair germ-like cysts became prevalent, markedly distorting the overlying epidermis (J:106792)
• showed malformed whiskers (J:106792)
• showed malformed whiskers (J:106792)




Genotype
MGI:3830547
cn9
Allelic
Composition
Cdh1tm2Kem/Cdh1tm2Kem
Tg(KRT14-cre)1Efu/0
Tg(Krt14-RNAi:Cdh3)1Efu/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh1tm2Kem mutation (1 available); any Cdh1 mutation (144 available)
Tg(KRT14-cre)1Efu mutation (0 available)
Tg(Krt14-RNAi:Cdh3)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 1 to 2 hours of birth (J:144091)
• mice die within 1 to 2 hours of birth (J:144091)

growth/size/body
• mice are small at birth (J:144091)
• mice are small at birth (J:144091)

homeostasis/metabolism
• unlike in wild-type mice, dye is readily absorbed through the paws, facial skin, ear buds and lower belly (J:144091)
• unlike in wild-type mice, dye is readily absorbed through the paws, facial skin, ear buds and lower belly (J:144091)

integument
• mice exhibit focal gaps in the epithelial sheets of the epidermis due to degeneration of cells (J:144091)
• however, desmosomes are still present in normal numbers (J:144091)
• intercellular junctions are perturbed unlike in wild-type epidermis (J:144091)
• adherence and tight junction components fail to localize to cell borders unlike in wild-type epidermis (J:144091)
• mice exhibit focal gaps in the epithelial sheets of the epidermis due to degeneration of cells (J:144091)
• however, desmosomes are still present in normal numbers (J:144091)
• intercellular junctions are perturbed unlike in wild-type epidermis (J:144091)
• adherence and tight junction components fail to localize to cell borders unlike in wild-type epidermis (J:144091)
• the typically columnar orientation of cells within the basal layer and flattened squamous morphology of the suprabasal cells are lost (J:144091)
• the typically columnar orientation of cells within the basal layer and flattened squamous morphology of the suprabasal cells are lost (J:144091)
• cells in the spinous layer fail to flatten as in wild-type mice (J:144091)
• cells in the spinous layer fail to flatten as in wild-type mice (J:144091)
• the typically columnar orientation of cells within the basal layer and flattened squamous morphology of the suprabasal cells are lost (J:144091)
• unlike in wild-type mice, cells within condensed nuclei indicating apoptosis are found in the suprabasal layer (J:144091)
• suprabasal keratin intermediate filament organization is perturbed compared to in wild-type mice (J:144091)
• the typically columnar orientation of cells within the basal layer and flattened squamous morphology of the suprabasal cells are lost (J:144091)
• unlike in wild-type mice, cells within condensed nuclei indicating apoptosis are found in the suprabasal layer (J:144091)
• suprabasal keratin intermediate filament organization is perturbed compared to in wild-type mice (J:144091)
• around the mouth, umbilicus and tail (J:144091)
• around the mouth, umbilicus and tail (J:144091)
• ventrally (J:144091)
• ventrally (J:144091)
• skin is inflexible (J:144091)
• skin is inflexible (J:144091)
• mice exhibit increased apoptosis in the epidermis compared to wild-type mice (J:144091)
• however, cell proliferation in the epidermis is normal, and no inflammatory response is observed (J:144091)
• mice exhibit increased apoptosis in the epidermis compared to wild-type mice (J:144091)
• however, cell proliferation in the epidermis is normal, and no inflammatory response is observed (J:144091)
• unlike in wild-type mice, dye is readily absorbed through the paws, facial skin, ear buds and lower belly (J:144091)
• unlike in wild-type mice, dye is readily absorbed through the paws, facial skin, ear buds and lower belly (J:144091)




Genotype
MGI:4367771
cn10
Allelic
Composition
Kdrtm1.1Jamb/Kdrtm1.1Jamb
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1.1Jamb mutation (0 available); any Kdr mutation (12 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• skin lymphatic vessels are dilated and hyperplastic compared to in wild-type mice (J:154336)
• skin lymphatic vessels are dilated and hyperplastic compared to in wild-type mice (J:154336)




Genotype
MGI:5435568
cn11
Allelic
Composition
Porcntm1.1Vdv/Y
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Vdv mutation (1 available); any Porcn mutation (15 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Dental and skin abnormalities and alopecia in Porcntm1.1Vdv/Y Tg(KRT14-cre)1Efu/0 mice

integument
• in areas with thin skin the subcutaneous fat is directly adjacent to the outermost epidermal layers (J:186934)
• in areas with thin skin the subcutaneous fat is directly adjacent to the outermost epidermal layers (J:186934)
• have large areas of thin skin with alopecia (J:186934)
• mosaic pattern of the phenotype is consistent with variable Cre expression (J:186934)
• have large areas of thin skin with alopecia (J:186934)
• mosaic pattern of the phenotype is consistent with variable Cre expression (J:186934)
• early budding of epidermal cells to form the hair placodes does not take place (J:186934)
• early budding of epidermal cells to form the hair placodes does not take place (J:186934)
• have large areas of thin skin with alopecia (J:186934)
• mosaic pattern of the phenotype is consistent with variable Cre expression (J:186934)
• have large areas of thin skin with alopecia (J:186934)
• mosaic pattern of the phenotype is consistent with variable Cre expression (J:186934)

craniofacial
• missing and hypoplastic teeth (J:186934)
• missing and hypoplastic teeth (J:186934)

adipose tissue
• in areas with thin skin the subcutaneous fat is directly adjacent to the outermost epidermal layers (J:186934)
• in areas with thin skin the subcutaneous fat is directly adjacent to the outermost epidermal layers (J:186934)

growth/size/body
• missing and hypoplastic teeth (J:186934)
• missing and hypoplastic teeth (J:186934)

Mouse Models of Human Disease
OMIM ID Ref(s)
Focal Dermal Hypoplasia; FDH 305600 J:186934




Genotype
MGI:5435569
cn12
Allelic
Composition
Porcntm1.1Vdv/Porcn+
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Vdv mutation (1 available); any Porcn mutation (15 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• barely detectable hair loss (J:186934)
• barely detectable hair loss (J:186934)




Genotype
MGI:2652092
cn13
Allelic
Composition
Dsptm1Efu/Dsptm1Efu
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsptm1Efu mutation (1 available); any Dsp mutation (5 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mice have severe intracellular adhesion defects (J:67797)
• mice have severe intracellular adhesion defects (J:67797)

integument
• large sections of the epidermis are missing and visible peeling occurs (J:67797)
• large sections of the epidermis are missing and visible peeling occurs (J:67797)
• after mechanical stress, newborn mice show epithelial peeling (J:73084)
• after mechanical stress, newborn mice show epithelial peeling (J:73084)
• at E18.5, intracellular separation is pronounced (J:73084)
• at E18.5, intracellular separation is pronounced (J:73084)
• cornified envelopes are bubble-bath like (J:73084)
• cornified envelopes are bubble-bath like (J:73084)
• at E18.5, intracellular separation is pronounced (J:73084)
• at E18.5, intracellular separation is pronounced (J:73084)




Genotype
MGI:4413470
cn14
Allelic
Composition
Tcf3tm1.1Efu/Tcf3tm1.1Efu
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1.1Efu mutation (0 available); any Tcf3 mutation (21 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice appear phenotypically normal (J:155012)
• mice appear phenotypically normal (J:155012)




Genotype
MGI:4413471
cn15
Allelic
Composition
Tcf3tm1.1Efu/Tcf3tm1.1Efu
Tcf7l2tm1Cle/Tcf7l2tm1Cle
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1.1Efu mutation (0 available); any Tcf3 mutation (21 available)
Tcf7l2tm1Cle mutation (0 available); any Tcf7l2 mutation (19 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• hair follicles appear but exhibit defects in subsequent down-growth compared to in wild-type mice (J:155012)
• hair follicles appear but exhibit defects in subsequent down-growth compared to in wild-type mice (J:155012)
• in skin grafts (J:155012)
• in skin grafts (J:155012)
• newborn mice often lack whiskers unlike wild-type mice (J:155012)
• newborn mice often lack whiskers unlike wild-type mice (J:155012)
• basal cells are flattened unlike in wild-type mice (J:155012)
• basal cells are flattened unlike in wild-type mice (J:155012)
• in newborn mice (J:155012)
• in newborn mice (J:155012)
• at P0, skin cells exhibit increased cell death compared to in wild-type mice (J:155012)
• grafted skin exhibits no hair and shrunk area without inflammation compared with wild-type skin grafts (J:155012)
• cultured skin epithelial fails to undergo long-term tissue maintenance unlike wild-type skin (J:155012)
• at P0, skin cells exhibit increased cell death compared to in wild-type mice (J:155012)
• grafted skin exhibits no hair and shrunk area without inflammation compared with wild-type skin grafts (J:155012)
• cultured skin epithelial fails to undergo long-term tissue maintenance unlike wild-type skin (J:155012)
• cultured keratinocytes from P0 mice exhibit decreased proliferation compared with wild-type cells (J:155012)
• cultured keratinocytes from P0 mice exhibit decreased proliferation compared with wild-type cells (J:155012)

cellular
• cultured keratinocytes from P0 mice exhibit decreased proliferation compared with wild-type cells (J:155012)
• cultured keratinocytes from P0 mice exhibit decreased proliferation compared with wild-type cells (J:155012)




Genotype
MGI:3714928
cn16
Allelic
Composition
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(KRT14-cre)1Efu/?
Genetic
Background
involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1tm1Chrn mutation (0 available); any Map2k1 mutation (81 available)
Map2k2tm1Chrn mutation (0 available); any Map2k2 mutation (9 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the majority of mice die within 24 hours of birth (J:122484)
• the majority of mice die within 24 hours of birth (J:122484)

digestive/alimentary system
• mice display full-thickness epithelium death and detachment from the underlying tissue (J:122484)
• however, suckling behavior was not altered (J:122484)
• mice display full-thickness epithelium death and detachment from the underlying tissue (J:122484)
• however, suckling behavior was not altered (J:122484)

growth/size/body
• mice display full-thickness epithelium death and detachment from the underlying tissue (J:122484)
• however, suckling behavior was not altered (J:122484)
• mice display full-thickness epithelium death and detachment from the underlying tissue (J:122484)
• however, suckling behavior was not altered (J:122484)
• ear flaps are detached (J:122484)
• ear flaps are detached (J:122484)
• mice are smaller at birth (J:122484)
• mice are smaller at birth (J:122484)
• mice lose 4%-10% of birth weight within 6 hours (J:122484)
• mice lose 4%-10% of birth weight within 6 hours (J:122484)

hearing/vestibular/ear
• ear flaps are detached (J:122484)
• ear flaps are detached (J:122484)

vision/eye
• in some mice (J:122484)
• in some mice (J:122484)

homeostasis/metabolism
• mice lose 4%-10% of birth weight within 6 hours and dye is more readily absorbed than in wild-type mice (J:122484)
• mice lose 4%-10% of birth weight within 6 hours and dye is more readily absorbed than in wild-type mice (J:122484)

craniofacial
• mice display full-thickness epithelium death and detachment from the underlying tissue (J:122484)
• however, suckling behavior was not altered (J:122484)
• mice display full-thickness epithelium death and detachment from the underlying tissue (J:122484)
• however, suckling behavior was not altered (J:122484)
• ear flaps are detached (J:122484)
• ear flaps are detached (J:122484)

integument
• at E17.5, keratinocytes in the basal layer but not in the hair follicles undergo increased apoptosis compared to normal (J:122484)
• at E17.5, keratinocytes in the basal layer but not in the hair follicles undergo increased apoptosis compared to normal (J:122484)
• mice lose 4%-10% of birth weight within 6 hours and dye is more readily absorbed than in wild-type mice (J:122484)
• mice lose 4%-10% of birth weight within 6 hours and dye is more readily absorbed than in wild-type mice (J:122484)
• fewer hair follicles are present including 37% fewer peleage follicles (J:122484)
• hair follicles undergo reduced proliferation (J:122484)
• fewer hair follicles are present including 37% fewer peleage follicles (J:122484)
• hair follicles undergo reduced proliferation (J:122484)
• 90% fewer vibrissae follicles compared to wild-type mice (J:122484)
• 90% fewer vibrissae follicles compared to wild-type mice (J:122484)
• epidermis is hypoplastic (J:122484)
• epidermis is hypoplastic (J:122484)

cellular
• at E17.5, keratinocytes in the basal layer but not in the hair follicles undergo increased apoptosis compared to normal (J:122484)
• at E17.5, keratinocytes in the basal layer but not in the hair follicles undergo increased apoptosis compared to normal (J:122484)




Genotype
MGI:2448680
cn17
Allelic
Composition
Itgb1tm1Efu/Itgb1tm1Efu
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm1Efu mutation (1 available); any Itgb1 mutation (13 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• usually die within a few hours of birth (J:65039)
• usually die within a few hours of birth (J:65039)

integument
• hair follicle keratinocytes fail to remodel basement membrane and invaginate into the dermis (J:65039)
• hair follicle keratinocytes fail to remodel basement membrane and invaginate into the dermis (J:65039)
• developing hair follicles are scarce, although a few mature hair follicles, most likely guard hairs, are detected (J:65039)
• developing hair follicles are scarce, although a few mature hair follicles, most likely guard hairs, are detected (J:65039)
• epidermal proliferation is inhibited, however a spatial and temporal program of terminal differentiation does occur (J:65039)
• epidermal proliferation is inhibited, however a spatial and temporal program of terminal differentiation does occur (J:65039)
• basal cells of the epidermis are flat and the nucleus is oriented parallel to the basement membrane (J:65039)
• basal cells of the epidermis are flat and the nucleus is oriented parallel to the basement membrane (J:65039)
• epidermis consists of a flattened basal layer and only one or two layers of suprabasal layers before the stratum corneum (J:65039)
• epidermis consists of a flattened basal layer and only one or two layers of suprabasal layers before the stratum corneum (J:65039)
• many areas of skin exhibit separations at the dermal-epidermal junction, such that in severely affected areas, the epidermis is detached entirely from the dermis (J:65039)
• many areas of skin exhibit separations at the dermal-epidermal junction, such that in severely affected areas, the epidermis is detached entirely from the dermis (J:65039)
• severe skin blistering (J:65039)
• severe skin blistering (J:65039)
• exhibit separation of the dermal-epidermal junction upon mechanical trauma, indicating fragile skin, however do not display denuding (J:65039)
• exhibit separation of the dermal-epidermal junction upon mechanical trauma, indicating fragile skin, however do not display denuding (J:65039)
• thin and fragile (J:65039)
• thin and fragile (J:65039)

cellular
• basement membrane assembly/organization is impaired, leading to a loss of extracellular matrix and hemidesmosomes (J:65039)
• skin shows discontinuity of the lamina densa (J:65039)
• basement membrane assembly/organization is impaired, leading to a loss of extracellular matrix and hemidesmosomes (J:65039)
• skin shows discontinuity of the lamina densa (J:65039)




Genotype
MGI:3720633
cn18
Allelic
Composition
Ctnna1tm1Efu/Ctnna1tm1Efu
Tg(KRT14-cre)1Efu/?
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnna1tm1Efu mutation (1 available); any Ctnna1 mutation (114 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mice have severe intracellular adhesion defects (J:67797)
• mice have severe intracellular adhesion defects (J:67797)
• in culture, keratinocytes overgrow the monolayer, grow faster than wild-type cells, do not require a feeder layer, are more sensitive to growth factors, and have an increased ability to breakdown matrix (J:67797)
• in culture, keratinocytes overgrow the monolayer, grow faster than wild-type cells, do not require a feeder layer, are more sensitive to growth factors, and have an increased ability to breakdown matrix (J:67797)

craniofacial

limbs/digits/tail
• limbs fail to develop completely (J:67797)
• limbs fail to develop completely (J:67797)

integument
• in culture, keratinocytes overgrow the monolayer, grow faster than wild-type cells, do not require a feeder layer, are more sensitive to growth factors, and have an increased ability to breakdown matrix (J:67797)
• in culture, keratinocytes overgrow the monolayer, grow faster than wild-type cells, do not require a feeder layer, are more sensitive to growth factors, and have an increased ability to breakdown matrix (J:67797)
• mice have diminished signs of hair follicle development (J:67797)
• mice have diminished signs of hair follicle development (J:67797)
• epidermal-dermal boundary was difficult to discern (J:67797)
• clumps of keratinocytes with morphology and differentiation characteristic of epidermis and not hair follicles and that are devoid of surface epidermis are present within the dermis (J:67797)
• epidermal-dermal boundary was difficult to discern (J:67797)
• clumps of keratinocytes with morphology and differentiation characteristic of epidermis and not hair follicles and that are devoid of surface epidermis are present within the dermis (J:67797)
• large sections of the epidermis are missing (J:67797)
• large sections of the epidermis are missing (J:67797)
• epidermis is thick and disorganized, particularly within the basal cell layer (J:67797)
• basal cells are round and spinous (J:67797)
• epidermis is thick and disorganized, particularly within the basal cell layer (J:67797)
• basal cells are round and spinous (J:67797)
• keratinocytes are frequently binucleated and unusually large (J:67797)
• keratinocytes are frequently binucleated and unusually large (J:67797)
• visible peeling occurs (J:67797)
• visible peeling occurs (J:67797)
• epidermis is thick and disorganized, particularly within the basal cell layer (J:67797)
• epidermal-dermal boundary was difficult to discern (J:67797)
• epidermis is thick and disorganized, particularly within the basal cell layer (J:67797)
• epidermal-dermal boundary was difficult to discern (J:67797)

growth/size/body




Genotype
MGI:3774840
cn19
Allelic
Composition
Atf2tm3Nicj/Atf2tm3Nicj
Tg(KRT14-cre)1Efu/?
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm3Nicj mutation (0 available); any Atf2 mutation (59 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• the median appearance of skin papillomas after topical application of carcinogens is five to six weeks earlier than in littermate controls (J:131564)
• mice have significantly greater numbers of papillomas 20 weeks after carcinogen treatment with a mean of 7 compared to 3 in littermate controls (J:131564)
• the median appearance of skin papillomas after topical application of carcinogens is five to six weeks earlier than in littermate controls (J:131564)
• mice have significantly greater numbers of papillomas 20 weeks after carcinogen treatment with a mean of 7 compared to 3 in littermate controls (J:131564)

integument
• the percentage of proliferating epithelial cells after TPA administration is twice that of littermate controls (J:131564)
• reduced levels of active caspase 3 were observed in the skin of mice treated with carcinogens suggesting apoptosis levels might be lower (J:131564)
• the percentage of proliferating epithelial cells after TPA administration is twice that of littermate controls (J:131564)
• reduced levels of active caspase 3 were observed in the skin of mice treated with carcinogens suggesting apoptosis levels might be lower (J:131564)
• mice develop a significantly thickened hyperdermis after three topical applications of TPA (J:131564)
• thickness is twice that of wild-type mice after TPA application (J:131564)
• mice develop a significantly thickened hyperdermis after three topical applications of TPA (J:131564)
• thickness is twice that of wild-type mice after TPA application (J:131564)
• the median appearance of skin papillomas after topical application of carcinogens is five to six weeks earlier than in littermate controls (J:131564)
• mice have significantly greater numbers of papillomas 20 weeks after carcinogen treatment with a mean of 7 compared to 3 in littermate controls (J:131564)
• the median appearance of skin papillomas after topical application of carcinogens is five to six weeks earlier than in littermate controls (J:131564)
• mice have significantly greater numbers of papillomas 20 weeks after carcinogen treatment with a mean of 7 compared to 3 in littermate controls (J:131564)




Genotype
MGI:5698459
cn20
Allelic
Composition
Mir203tm1.1Yir/Mir203tm1.1Yir
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir203tm1.1Yir mutation (1 available); any Mir203 mutation (2 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and exhibit no developmental defects (J:226044)
• mice are viable and exhibit no developmental defects (J:226044)




Genotype
MGI:5319526
cn21
Allelic
Composition
Ago1tm1.1Tara/Ago1tm1.1Tara
Tg(KRT14-cre)1Efu/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ago1tm1.1Tara mutation (1 available); any Ago1 mutation (103 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no developmental defects are detected (J:183622)
• no developmental defects are detected (J:183622)




Genotype
MGI:4888399
cn22
Allelic
Composition
Casp8tm1Hed/Casp8tm1Hed
Tg(KRT14-cre)1Efu/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8tm1Hed mutation (1 available); any Casp8 mutation (5 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 90% of mutants die by P15, while 10% survive for months (J:167299)
• about 90% of mutants die by P15, while 10% survive for months (J:167299)
• about 10% of mutants exhibit a mosaic skin phenotype and survive for months (J:167299)
• about 10% of mutants exhibit a mosaic skin phenotype and survive for months (J:167299)

integument
• mutants exhibit an increase in epidermal water loss (J:167299)
• mutants exhibit an increase in epidermal water loss (J:167299)
• mutants develop atopic dermatitis-like skin disease (J:167299)
• about 90% of mutants exhibit a uniform skin phenotype and die by P15 while mutants that survive longer than P15, exhibit the skin phenotype on the posterior region of the back skin (J:167299)
• mutants develop atopic dermatitis-like skin disease (J:167299)
• about 90% of mutants exhibit a uniform skin phenotype and die by P15 while mutants that survive longer than P15, exhibit the skin phenotype on the posterior region of the back skin (J:167299)
• 2.5-fold increase in the numbers of blood vessels in the skin as indicated by marker analysis (J:167299)
• 2.5-fold increase in the numbers of blood vessels in the skin as indicated by marker analysis (J:167299)
• cutaneous edema is seen in the ears and feet (J:167299)
• cutaneous edema is seen in the ears and feet (J:167299)
• affected skin of mutants surviving longer than P15 shows suprabasal cells with increased intracellular space, indicating development of spongiosis (J:167299)
• affected skin of mutants surviving longer than P15 shows suprabasal cells with increased intracellular space, indicating development of spongiosis (J:167299)
• hyperproliferation of epithelial stem/progenitor cells in the skin (J:167299)
• hyperproliferation of epithelial stem/progenitor cells in the skin (J:167299)
• the intracellular adhesion apparatus of the epidermis is disrupted, with keratinocytes showing an abnormal punctate localization of E-cadherin (Cdh1) due to increased shedding of E-cadherin (J:167299)
• the intracellular adhesion apparatus of the epidermis is disrupted, with keratinocytes showing an abnormal punctate localization of E-cadherin (Cdh1) due to increased shedding of E-cadherin (J:167299)
• mutants exhibit epidermal hyperplasia (J:167299)
• topical application of clobetasol, a corticosteroid, substantially reduces the epidermal hyperplasia and abolishes the epidermal gaps (J:167299)
• mutants exhibit epidermal hyperplasia (J:167299)
• topical application of clobetasol, a corticosteroid, substantially reduces the epidermal hyperplasia and abolishes the epidermal gaps (J:167299)

immune system
• mutants exhibit an increase in mast cells with age (J:167299)
• mutants exhibit an increase in mast cells with age (J:167299)
• IgE levels are normal in young mutants but adults show a 30-fold increase compared to wild-type mice (J:167299)
• IgE levels are normal in young mutants but adults show a 30-fold increase compared to wild-type mice (J:167299)
• 5-fold increase in serum IgG1 levels in adults (J:167299)
• 5-fold increase in serum IgG1 levels in adults (J:167299)
• marker analysis indicates that mutants exhibit a biphastic T-helper cell response, with a TH2 response during the acute phase of dermatitis followed by a TH1 response during the chronic phase of dermatitis (J:167299)
• marker analysis indicates that mutants exhibit a biphastic T-helper cell response, with a TH2 response during the acute phase of dermatitis followed by a TH1 response during the chronic phase of dermatitis (J:167299)
• mutants develop atopic dermatitis-like skin disease (J:167299)
• about 90% of mutants exhibit a uniform skin phenotype and die by P15 while mutants that survive longer than P15, exhibit the skin phenotype on the posterior region of the back skin (J:167299)
• mutants develop atopic dermatitis-like skin disease (J:167299)
• about 90% of mutants exhibit a uniform skin phenotype and die by P15 while mutants that survive longer than P15, exhibit the skin phenotype on the posterior region of the back skin (J:167299)

homeostasis/metabolism
• cutaneous edema is seen in the ears and feet (J:167299)
• cutaneous edema is seen in the ears and feet (J:167299)
• affected skin of mutants surviving longer than P15 shows suprabasal cells with increased intracellular space, indicating development of spongiosis (J:167299)
• affected skin of mutants surviving longer than P15 shows suprabasal cells with increased intracellular space, indicating development of spongiosis (J:167299)
• mutants exhibit an increase in epidermal water loss (J:167299)
• mutants exhibit an increase in epidermal water loss (J:167299)

hematopoietic system
• mutants exhibit an increase in mast cells with age (J:167299)
• mutants exhibit an increase in mast cells with age (J:167299)
• IgE levels are normal in young mutants but adults show a 30-fold increase compared to wild-type mice (J:167299)
• IgE levels are normal in young mutants but adults show a 30-fold increase compared to wild-type mice (J:167299)
• 5-fold increase in serum IgG1 levels in adults (J:167299)
• 5-fold increase in serum IgG1 levels in adults (J:167299)
• marker analysis indicates that mutants exhibit a biphastic T-helper cell response, with a TH2 response during the acute phase of dermatitis followed by a TH1 response during the chronic phase of dermatitis (J:167299)
• marker analysis indicates that mutants exhibit a biphastic T-helper cell response, with a TH2 response during the acute phase of dermatitis followed by a TH1 response during the chronic phase of dermatitis (J:167299)

cardiovascular system
• 2.5-fold increase in the numbers of blood vessels in the skin as indicated by marker analysis (J:167299)
• 2.5-fold increase in the numbers of blood vessels in the skin as indicated by marker analysis (J:167299)

Mouse Models of Human Disease
OMIM ID Ref(s)
Dermatitis, Atopic 603165 J:167299




Genotype
MGI:3826503
cx23
Allelic
Composition
Ctnnd1tm1Abre/Ctnnd1tm1Abre
Tg(KRT14-cre)1Efu/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnd1tm1Abre mutation (0 available); any Ctnnd1 mutation (76 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• mice die of an inflammatory skin disease by day 15 so to study effects of the alleles on skin cancer, new born back skin was grafted onto immunocompromised nude mice (J:143096)
• within 15 to 50 days after engraftment, 100% of grafts display signs of epidermal hyperkeratosis compared with their wild-type counterparts (J:143096)
• 50 days after engraftment, grafts develop raised nodules that soon began to ulcerate and adopt an erythematous crateriform appearance (J:143096)
• epithelial undulations with eosinophilic keratinized debris accompany the papilloma-like protuberances 50 days post engraftment (J:143096)
• by 70 days, dysplastic keratinocytes had populated the invaginations (J:143096)
• aberrant clusters of pigment-filled melanocytes, typically confined to skin epithelium, are frequent in the dermis after 70 days (J:143096)
• mice die of an inflammatory skin disease by day 15 so to study effects of the alleles on skin cancer, new born back skin was grafted onto immunocompromised nude mice (J:143096)
• within 15 to 50 days after engraftment, 100% of grafts display signs of epidermal hyperkeratosis compared with their wild-type counterparts (J:143096)
• 50 days after engraftment, grafts develop raised nodules that soon began to ulcerate and adopt an erythematous crateriform appearance (J:143096)
• epithelial undulations with eosinophilic keratinized debris accompany the papilloma-like protuberances 50 days post engraftment (J:143096)
• by 70 days, dysplastic keratinocytes had populated the invaginations (J:143096)
• aberrant clusters of pigment-filled melanocytes, typically confined to skin epithelium, are frequent in the dermis after 70 days (J:143096)

cellular
• binucleated cells are observed in newborn skin that is grafted onto nude mice (J:143096)
• these cells are often observed in differentiating layers (J:143096)
• binucleated cells are observed in newborn skin that is grafted onto nude mice (J:143096)
• these cells are often observed in differentiating layers (J:143096)

integument
• new born back skin grafted onto immunocompromised nude mice have a paucity of hair due to the development of skin tumors (J:143096)
• new born back skin grafted onto immunocompromised nude mice have a paucity of hair due to the development of skin tumors (J:143096)
• there is an enhancement of actively cycling cells in new born back skin grafted onto immunocompromised nude mice (J:143096)
• this hyperproliferation is dependent on surrounding inflammation and will normalize under anti-inflammatory treatment (J:143096)
• there is an enhancement of actively cycling cells in new born back skin grafted onto immunocompromised nude mice (J:143096)
• this hyperproliferation is dependent on surrounding inflammation and will normalize under anti-inflammatory treatment (J:143096)
• mice die of an inflammatory skin disease by day 15 so to study effects of the alleles on skin cancer, new born back skin was grafted onto immunocompromised nude mice (J:143096)
• within 15 to 50 days after engraftment, 100% of grafts display signs of epidermal hyperkeratosis compared with their wild-type counterparts (J:143096)
• 50 days after engraftment, grafts develop raised nodules that soon began to ulcerate and adopt an erythematous crateriform appearance (J:143096)
• epithelial undulations with eosinophilic keratinized debris accompany the papilloma-like protuberances 50 days post engraftment (J:143096)
• by 70 days, dysplastic keratinocytes had populated the invaginations (J:143096)
• aberrant clusters of pigment-filled melanocytes, typically confined to skin epithelium, are frequent in the dermis after 70 days (J:143096)
• mice die of an inflammatory skin disease by day 15 so to study effects of the alleles on skin cancer, new born back skin was grafted onto immunocompromised nude mice (J:143096)
• within 15 to 50 days after engraftment, 100% of grafts display signs of epidermal hyperkeratosis compared with their wild-type counterparts (J:143096)
• 50 days after engraftment, grafts develop raised nodules that soon began to ulcerate and adopt an erythematous crateriform appearance (J:143096)
• epithelial undulations with eosinophilic keratinized debris accompany the papilloma-like protuberances 50 days post engraftment (J:143096)
• by 70 days, dysplastic keratinocytes had populated the invaginations (J:143096)
• aberrant clusters of pigment-filled melanocytes, typically confined to skin epithelium, are frequent in the dermis after 70 days (J:143096)





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory