Itgb1^tm1Efu
Targeted Allele Detail

Summary

• Symbol: Itgb1^tm1Efu
• Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Elaine Fuchs
• MGI ID: MGI:1926499
• Synonyms: beta1^e3, beta1^flox, CD29^f, integrin beta1^flox, Itgb1^f, Itgb1^flox
• Gene: Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
• Alliance: Itgb1^tm1Efu page

Crypt hyperplasia and dysplasia and villous enlargement in Itgb1^tm1Efu/Itgb1^tm1Efu Tg(Vil1-cre)997Gum/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65039
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct contains a loxP site upstream of exon 3 and a loxP-flanked neomycin selection cassette downstream of exon 3. Cre-mediated recombination removed the downstream floxed neo cassette leaving exon 3 floxed. (J:65039)

Expression

In Mice Carrying this Mutation:	11 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	25 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Itgb1 Mutation: 59 strains or lines available

References

• Original: J:65039 Raghavan S, et al., Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol. 2000 Sep 4;150(5):1149-60
• All: 97 reference(s)