Tcf7l1^tm1.1Efu
Targeted Allele Detail

Summary

• Symbol: Tcf7l1^tm1.1Efu
• Name: transcription factor 7 like 1 (T cell specific, HMG box); targeted mutation 1.1, Elaine Fuchs
• MGI ID: MGI:4413464
• Synonyms: Tcf3^fl, Tcf3^tm1.1Efu
• Gene: Tcf7l1 Location: Chr6:72603354-72766028 bp, - strand Genetic Position: Chr6, 32.27 cM
• Alliance: Tcf7l1^tm1.1Efu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155012
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 2. Cre mediated recombination removed the neo cassette leaving exon 2 floxed. (J:155012)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7l1 Mutation: 84 strains or lines available

References

• Original: J:155012 Nguyen H, et al., Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet. 2009 Oct;41(10):1068-75
• All: 3 reference(s)