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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf7l1tm1.1Efu
targeted mutation 1.1, Elaine Fuchs
MGI:4413464
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tcf7l1tm1.1Efu/Tcf7l1tm1.1Efu
Tg(KRT14-cre)1Efu/0 		involves: 129 MGI:4413470
cn2
 		Tcf7l1tm1.1Efu/Tcf7l1tm1.1Efu
Tcf7l2tm1Cle/Tcf7l2tm1Cle
Tg(KRT14-cre)1Efu/0 		involves: 129/Sv * 129P2/OlaHsd MGI:4413471


Genotype
MGI:4413470
cn1
Allelic
Composition		 Tcf7l1tm1.1Efu/Tcf7l1tm1.1Efu
Tg(KRT14-cre)1Efu/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l1tm1.1Efu mutation (0 available); any Tcf7l1 mutation (84 available)
Tg(KRT14-cre)1Efu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:155012 )
• mice appear phenotypically normal




Genotype
MGI:4413471
cn2
Allelic
Composition		 Tcf7l1tm1.1Efu/Tcf7l1tm1.1Efu
Tcf7l2tm1Cle/Tcf7l2tm1Cle
Tg(KRT14-cre)1Efu/0
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l1tm1.1Efu mutation (0 available); any Tcf7l1 mutation (84 available)
Tcf7l2tm1Cle mutation (0 available); any Tcf7l2 mutation (56 available)
Tg(KRT14-cre)1Efu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal hair follicle morphology ( J:155012 )
• hair follicles appear but exhibit defects in subsequent down-growth compared to in wild-type mice
absent hair follicles ( J:155012 )
• in skin grafts
absent vibrissae ( J:155012 )
• newborn mice often lack whiskers unlike wild-type mice
abnormal epidermis stratum basale morphology ( J:155012 )
• basal cells are flattened unlike in wild-type mice
thin skin ( J:155012 )
• in newborn mice
abnormal skin physiology ( J:155012 )
• at P0, skin cells exhibit increased cell death compared to in wild-type mice
• grafted skin exhibits no hair and shrunk area without inflammation compared with wild-type skin grafts
• cultured skin epithelial fails to undergo long-term tissue maintenance unlike wild-type skin
decreased keratinocyte proliferation ( J:155012 )
• cultured keratinocytes from P0 mice exhibit decreased proliferation compared with wild-type cells

cellular
decreased keratinocyte proliferation ( J:155012 )
• cultured keratinocytes from P0 mice exhibit decreased proliferation compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory