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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
a
nonagouti
MGI:1855937
Summary 123 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
a/a involves: SM/J MGI:3789001
hm2
a/a Not Specified MGI:5460860
ht3
ax/a B6.Cg-ax MGI:5085916
ht4
Ay/a B6.Cg-Ay/J MGI:3799322
ht5
au/a (C3H/HeH x 101/H)F1 MGI:2687037
ht6
a/Aw-22J C57BL/10Rk MGI:5446397
ht7
Aw-27J/a C57BL/6J MGI:5463495
ht8
Asy/a C57BL/6J MGI:3052033
ht9
Aw-46J/a C57BL/6J MGI:2181394
ht10
a/Aw-20J C57BL/6J MGI:5446384
ht11
Aw-26J/a C57BL/6J MGI:5463493
ht12
atd/a C57BL/6J-atd/J MGI:3819402
ht13
Atm1Brd/a C57BL/6N-Atm1Brd MGI:3849879
ht14
Atm1.1Arte/a C57BL/6NTac-Atm1.1Arte/a MGI:5585625
ht15
a/a17H involves: 101/H * C3H/HeH MGI:5299224
ht16
a/a6H involves: 101/H * C3H/HeH MGI:3051515
ht17
al/a involves: 101/H * C3H/HeH MGI:3611222
ht18
a/a13H involves: 101/H * C3H/HeH MGI:5299221
ht19
am/a involves: 101/Rl * C3H/Rl MGI:4829948
ht20
ax/a involves: 101/Rl * C3H/Rl MGI:5085915
ht21
a/a19H involves: C3H/HeH MGI:5299235
ht22
Avy/a involves: C3H/HeJ * C57BL/6 MGI:3772367
ht23
am-J/a involves: C3H/HeJ * C57BL/6J MGI:3805305
ht24
Avy/a involves: C57BL/6J MGI:3778284
ht25
Aw-15J/a involves: C57BL/6J * DBA/2J MGI:5444873
ht26
Ay/a involves: KK MGI:3760281
ht27
Aw/a involves: SM/J MGI:3789002
ht28
a/a20H Not Specified MGI:5299236
ht29
ajl41/a Not Specified MGI:3047815
ht30
ajl10/a Not Specified MGI:3047806
ht31
ajl85/a Not Specified MGI:3047817
ht32
a/atwp Not Specified MGI:4367209
cx33
a/a
Hps6ru/Hps6ru
B6.Cg-Hps6ru MGI:3805043
cx34
a/a
KitW-2J/Kit+
C57BL/6J MGI:3813609
cx35
Ay/a
Sik2tm1Htake/Sik2+
C57BL/6-Sik2tm1Htake MGI:5609871
cx36
a/a
Mlphln/Mlphln
Tyrp1b/Tyrp1b
C57L/J MGI:3052536
cx37
A/a
In(11Trp53;11Wnt3)8Brd/+
either: (involves: 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * C57BL/6Brd * C57BL/6J) MGI:5766498
cx38
a/a
Pax3Sp-1H/Pax3Sp-1H
involves: 101/H * C3H/HeH * C57BL/6 MGI:5636497
cx39
Ay/a
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Mae/Ccr2tm1Mae
involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl MGI:5297861
cx40
Ay/a
Apoetm1Unc/Apoetm1Unc
involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl MGI:5297860
cx41
Avy/a
Axin1Fu/Axin1+
involves: 129P4/RrRk * C67BL/6J MGI:3778273
cx42
Ay/a
Npbwr1tm1Rck/Npbwr1tm1Rck
involves: 129P/Ola * C57BL/6J MGI:3526898
cx43
Ay/a
Agrptm2(DTR)Rpa/Agrp+
involves: 129S4/SvJaeSor * KK/Upj MGI:3776093
cx44
a/A
Pomctm1Sora/Pomctm1Sora
involves: 129S6/SvEvTac MGI:3805940
cx45
a/a
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
involves: 129S6/SvEvTac * C57BL/6Ha MGI:3805943
cx46
a/A
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
involves: 129S6/SvEvTac * C57BL/6Ha MGI:3805942
cx47
a/a
In(11Trp53;11Wnt3)8Brd/+
involves: 129S7/SvEvBrd * C57BL/6Brd * C57BL/6J MGI:5766500
cx48
Aw/a
Corintm1Bamo/Corintm1Bamo
involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:3772887
cx49
a/a
Corintm1Bamo/Corintm1Bamo
involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:3772889
cx50
a/a
DctSlt-lt/DctSlt-lt
involves: C3H/HeJ MGI:5763608
cx51
a/a
DctSlt-lt/Dct+
involves: C3H/HeJ MGI:5763609
cx52
a/a
Oca2p-J/Oca2p-J
involves: C3H/HeJ MGI:4454423
cx53
a/a
Lystbg/Lystbg
Oca2p-J/Oca2p-J
involves: C3H/HeJ * C3H/Rl * C57BL/6J MGI:4454430
cx54
a/a
Rab27aash/Rab27aash
involves: C3H/HeSnJ * C57BL/6J MGI:5505784
cx55
a/a
Lystbg/Lystbg
Tyrc/Tyrc
involves: C3H/Rl * C57BL/6J MGI:4454429
cx56
a/a
Lystbg/Lystbg
Tyrp1b/Tyrp1b
involves: C3H/Rl * C57BL/6J MGI:4454432
cx57
a/a
Lystbg/Lystbg
involves: C3H/Rl * C57BL/6J MGI:4454426
cx58
a/a
Hps6ru/Hps6ru
Lystbg/Lystbg
involves: C3H/Rl * C57BL/6J MGI:4454431
cx59
a/a
Hps6ru/Hps6ru
involves: C57BL/6J MGI:4454424
cx60
a/a
Bloc1s6pa/Bloc1s6pa
involves: C57BL/6J MGI:4454434
cx61
a/a
Mregdsu/Mregdsu
Hps6ru/Hps6ru
involves: C57BL/6J MGI:5466757
cx62
a/a
Tyrc/Tyrc
involves: C57BL/6J MGI:4454419
cx63
a/a
Tyrp1b/Tyrp1b
involves: C57BL/6J MGI:4454425
cx64
Ay/a
Mssq9C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833969
cx65
Ay/a
Mssq1KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833436
cx66
a/a
Mssq1KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833437
cx67
Ay/a
Mssq2C57BL/6JJcl/Mssq2KK/TaJcl
involves: C57BL/6JJcl * KK/TaJcl MGI:3833439
cx68
Ay/a
Mssq3KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833448
cx69
a/a
Mssq3KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833451
cx70
Ay/a
Mssq4KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833452
cx71
a/a
Mssq4KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833453
cx72
Ay/a
Mssq5C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833454
cx73
a/a
Mssq5C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833455
cx74
Ay/a
Mssq6C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833456
cx75
a/a
Mssq6C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833457
cx76
Ay/a
Mssq6KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833460
cx77
a/a
Mssq6KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833461
cx78
Ay/a
Mssq7KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833471
cx79
a/a
Mssq7KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833472
cx80
a/a
Mssq8C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833967
cx81
a/a
Mssq9C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833968
cx82
a/a
Mssq10KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833970
cx83
Ay/a
Mssq10KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833971
cx84
a/a
Mssq11KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833972
cx85
Ay/a
Mssq11KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833973
cx86
a/a
Mssq12KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833974
cx87
Ay/a
Mssq12KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833975
cx88
a/a
Mssq13KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833976
cx89
Ay/a
Mssq13KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833977
cx90
a/a
Mssq13C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833978
cx91
Ay/a
Mssq13C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833979
cx92
a/a
Mssq14KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833980
cx93
Ay/a
Mssq14KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833981
cx94
a/a
Mssq15C57BL/6JJcl/Mssq15KK/TaJcl
involves: C57BL/6JJcl * KK/TaJcl MGI:3833982
cx95
a/a
Mssq16KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833983
cx96
Ay/a
Mssq16KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833984
cx97
a/a
Zc3h4KK/Zc3h4KK
involves: C57BL/6J * KK-Ay MGI:2175418
cx98
a/Ay
Guq2C57BL/6J/Guq2C57BL/6J
involves: C57BL/6J * KK-Ay MGI:3773903
cx99
a/Ay
Bwq10C57BL/6J/Bwq10C57BL/6J
involves: C57BL/6J * KK-Ay MGI:3773901
cx100
a/Ay
Bwq2KK/Bwq2KK
involves: C57BL/6J * KK-Ay MGI:3487268
cx101
a/Ay
Zc3h4C57BL/6J/Zc3h4KK
involves: C57BL/6J * KK-Ay MGI:2679981
cx102
a/Ay
Zc3h4KK/Zc3h4KK
involves: C57BL/6J * KK-Ay MGI:2679980
cx103
a/Ay
Guq1KK/Guq1KK
involves: C57BL/6J * KK-Ay MGI:3773902
cx104
Ay/a
Rmi1Gt(pUHachi)0283Imeg/Rmi1+
involves: C57BL/6 * KK MGI:4936833
cx105
a/a
Rmi1Gt(pUHachi)0283Imeg/Rmi1+
involves: C57BL/6 * KK MGI:4936834
cx106
a/a
Mlphln/Mlphln
involves: C57BL/J * C57BR MGI:4454435
cx107
a/a
Myo5ad/Myo5a+
Oca2p/Oca2+
Tyrp1B-lt/Tyrp1+
involves: C58 * CT/Ch MGI:3795191
cx108
a/a
Myo5ad/Myo5ad
involves: DBA/2J MGI:4454433
cx109
Ay/a
Dmbx1tm1Sse/Dmbx1tm1Sse
involves: ICR MGI:3759412
cx110
a/a
Tyrc-i/Tyrc-i
involves: STOCK Tyrc-r MGI:2663195
cx111
Ay/a
Ednrbs/Ednrbs
Not Specified MGI:5086233
cx112
a/a
Oca2p/Oca2p
Not Specified MGI:3844692
cx113
a/a
U/U
Not Specified MGI:3844552
cx114
Ay/a
Tyrp1B-lt/?
Not Specified MGI:3795189
cx115
A/a
Tyrp1B-lt/Tyrp1B-lt
Not Specified MGI:3795188
cx116
a/a
Tyrp1B-lt/Tyrp1+
Not Specified MGI:3795185
cx117
a/a
Tyrp1b/Tyrp1b
wad/wad+
Not Specified MGI:4818897
cx118
a/a
Tyrp1b/Tyrp1b
wad/wad
Not Specified MGI:4818908
cx119
a/a
Hps6ru/Hps6ru
Not Specified MGI:4361342
cx120
a/a
Tyrp1B-lt/Tyrp1B-lt
Not Specified MGI:3795183
cx121
a/a
Myo5ad/Myo5ad
Not Specified MGI:5440857
cx122
a/a
Tyrp1b/Tyrp1b
Not Specified MGI:5440939
cx123
a/a
Mlphln/Mlphln
Not Specified MGI:5468335


Genotype
MGI:3789001
hm1
Allelic
Composition
a/a
Genetic
Background
involves: SM/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• total cortex and x-zone of adrenal cortex are of similar thickness to Aw/a or Aw/ Aw 70-day old virgin mice
• X-zone is composed exclusively of non-vacuolated cells
• zona glomerulosa, zona fasciculata, and zona reticularis are morphologically similar between genotypes




Genotype
MGI:5460860
hm2
Allelic
Composition
a/a
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• hairs lack the yellow pigment band found in the wild-type agouti black coat
• hairs are black except for yellow hairs around ears, mammae, and perineum

pigmentation
• hairs lack the yellow pigment band found in the wild-type agouti black coat
• hairs are black except for yellow hairs around ears, mammae, and perineum




Genotype
MGI:5085916
ht3
Allelic
Composition
ax/a
Genetic
Background
B6.Cg-ax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
ax mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• at 3-4 weeks of age, mice of this genotype have more yellow-banded agouti hair on their sides than do homozygous non-agouti mice
• at 3-4 weeks of age, a paler ventrum distinguishes this genotype from homozygous non-agouti or mice

pigmentation
• at 3-4 weeks of age, mice of this genotype have more yellow-banded agouti hair on their sides than do homozygous non-agouti mice
• at 3-4 weeks of age, a paler ventrum distinguishes this genotype from homozygous non-agouti or mice




Genotype
MGI:3799322
ht4
Allelic
Composition
Ay/a
Genetic
Background
B6.Cg-Ay/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ay/a mouse

behavior/neurological
• the stress of isolation, restraint, or ip injection inhibits feeding

pigmentation
• tyrosinase levels in hairbulb melanocytes ,as determined by 35S methionine incorporation and immunotitration, are reduced in comparison to a/a controls
• decreased tyrosinase suggests the production of predominantly phaeomelanin (yellow)

integument
• tyrosinase levels in hairbulb melanocytes ,as determined by 35S methionine incorporation and immunotitration, are reduced in comparison to a/a controls
• decreased tyrosinase suggests the production of predominantly phaeomelanin (yellow)




Genotype
MGI:2687037
ht5
Allelic
Composition
au/a
Genetic
Background
(C3H/HeH x 101/H)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
au mutation (2 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• with a, coat is nonagouti on the back with dark agouti belly and pinna hairs are yellow
• with at, coat is nonagouti on the back with tan belly and pinna hairs are yellow

integument
• with a, coat is nonagouti on the back with dark agouti belly and pinna hairs are yellow
• with at, coat is nonagouti on the back with tan belly and pinna hairs are yellow




Genotype
MGI:5446397
ht6
Allelic
Composition
a/Aw-22J
Genetic
Background
C57BL/10Rk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Aw-22J mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the genetic background indicates the mouse should be non-agouti black however the dorsal coat is agouti
• the ventrum is cream to white not non-agouti black as inferred from the strain background

pigmentation
• the genetic background indicates the mouse should be non-agouti black however the dorsal coat is agouti
• the ventrum is cream to white not non-agouti black as inferred from the strain background




Genotype
MGI:5463495
ht7
Allelic
Composition
Aw-27J/a
Genetic
Background
C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Aw-27J mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the ventrum and flank coat is agouti
• the ventrum is white or "light"

pigmentation
• the ventrum and flank coat is agouti
• the ventrum is white or "light"




Genotype
MGI:3052033
ht8
Allelic
Composition
Asy/a
Genetic
Background
C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Asy mutation (2 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• dark or sooty yellow due to black tips on otherwise yellow hair

integument
• dark or sooty yellow due to black tips on otherwise yellow hair




Genotype
MGI:2181394
ht9
Allelic
Composition
Aw-46J/a
Genetic
Background
C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Aw-46J mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5446384
ht10
Allelic
Composition
a/Aw-20J
Genetic
Background
C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Aw-20J mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the genetic background indicates the mouse should be non-agouti black however the dorsal coat is agouti
• the ventrum is cream to white not non-agouti black as inferred from the strain background

pigmentation
• the genetic background indicates the mouse should be non-agouti black however the dorsal coat is agouti
• the ventrum is cream to white not non-agouti black as inferred from the strain background




Genotype
MGI:5463493
ht11
Allelic
Composition
Aw-26J/a
Genetic
Background
C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Aw-26J mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the ventral and flank coat is agouti instead of the expected non-agouti black
• the ventrum is white or "light"

pigmentation
• the ventral and flank coat is agouti instead of the expected non-agouti black
• the ventrum is white or "light"




Genotype
MGI:3819402
ht12
Allelic
Composition
atd/a
Genetic
Background
C57BL/6J-atd/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
atd mutation (1 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• the first coat has a tan belly with agouti hairs among the mostly black hairs on the side of the body, and after the first molt the agouti hairs spread over the back so that the back appears to be a darkened agouti color, instead of black
• appearance resembles Aw/?

integument
• the first coat has a tan belly with agouti hairs among the mostly black hairs on the side of the body, and after the first molt the agouti hairs spread over the back so that the back appears to be a darkened agouti color, instead of black
• appearance resembles Aw/?




Genotype
MGI:3849879
ht13
Allelic
Composition
Atm1Brd/a
Genetic
Background
C57BL/6N-Atm1Brd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Atm1Brd mutation (62 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• mice heterozygous for this targeted reversion to agouti on an otherwise normal C57BL/6N background have uniformly agouti coats, the hairs on both dorsum and ventrum having a subapical yellow band; this differs from the phenotype of a spontaneous revertant of nonagouti that occurred in C57BL/6J, Aw-J, which results in a light- or white-bellied agouti coat

integument
N
• mice heterozygous for this targeted reversion to agouti on an otherwise normal C57BL/6N background have uniformly agouti coats, the hairs on both dorsum and ventrum having a subapical yellow band; this differs from the phenotype of a spontaneous revertant of nonagouti that occurred in C57BL/6J, Aw-J, which results in a light- or white-bellied agouti coat




Genotype
MGI:5585625
ht14
Allelic
Composition
Atm1.1Arte/a
Genetic
Background
C57BL/6NTac-Atm1.1Arte/a
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Atm1.1Arte mutation (1 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• mice bearing this mutation on the C57BL/6NTac background exhibit a change in coat pigmentation from the characteristic black of the background strain to the wild-type agouti pattern, i.e., black and yellow banding of individual hairs.

normal phenotype
• mice bearing this mutation on the C57BL/6NTac background exhibit a change in coat pigmentation from the characteristic black of the background strain to the wild-type agouti pattern, i.e., black and yellow banding of individual hairs.

pigmentation
N
• mice bearing this mutation on the C57BL/6NTac background exhibit a change in coat pigmentation from the characteristic black of the background strain to the wild-type agouti pattern, i.e., black and yellow banding of individual hairs.




Genotype
MGI:5299224
ht15
Allelic
Composition
a/a17H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
a17H mutation (1 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument

pigmentation




Genotype
MGI:3051515
ht16
Allelic
Composition
a/a6H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
a6H mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• with nonagouti the coat color is umbrous with yellow pinna hairs
• pinna hairs are yellow, unexpected for this genotype

integument
• with nonagouti the coat color is umbrous with yellow pinna hairs
• pinna hairs are yellow, unexpected for this genotype




Genotype
MGI:3611222
ht17
Allelic
Composition
al/a
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
al mutation (1 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• appears as aa, homozygous nonagouti black




Genotype
MGI:5299221
ht18
Allelic
Composition
a/a13H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
a13H mutation (1 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument

pigmentation




Genotype
MGI:4829948
ht19
Allelic
Composition
am/a
Genetic
Background
involves: 101/Rl * C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
am mutation (2 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• the genetic background of the mother influences the coat pattern of the offspring

pigmentation
• Background Sensitivity: there is a continuum of color pattern ranging from all black indistinguishable from mice with a ae genotype, see ae , to degrees of yellow mottling on a black background, to mice with an agouti coat color pattern (J:5964)
• Background Sensitivity: the genetic background of the mother influences the coat pattern of the offspring (J:5964)
• mice are mottled with agouti and nonagouti patches of fur with hairs of both types intermingled at the pattern edges (J:29504)
• matings of genotype am/a to a/a mice produce about 50% mottled offspring

integument
• Background Sensitivity: there is a continuum of color pattern ranging from all black indistinguishable from mice with a ae genotype, see ae , to degrees of yellow mottling on a black background, to mice with an agouti coat color pattern (J:5964)
• Background Sensitivity: the genetic background of the mother influences the coat pattern of the offspring (J:5964)
• mice are mottled with agouti and nonagouti patches of fur with hairs of both types intermingled at the pattern edges (J:29504)
• matings of genotype am/a to a/a mice produce about 50% mottled offspring




Genotype
MGI:5085915
ht20
Allelic
Composition
ax/a
Genetic
Background
involves: 101/Rl * C3H/Rl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
ax mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the coat is slightly paler than that of a homozygous non-agouti coat

pigmentation
• the coat is slightly paler than that of a homozygous non-agouti coat




Genotype
MGI:5299235
ht21
Allelic
Composition
a/a19H
Genetic
Background
involves: C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
a19H mutation (1 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument

pigmentation




Genotype
MGI:3772367
ht22
Allelic
Composition
Avy/a
Genetic
Background
involves: C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Avy mutation (7 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Spectrum of coat colors in Avy/a mice

growth/size/body

pigmentation
• variable coat color ranging from yellow, mosaic yellow/agouti, or pseudoagouti

neoplasm

integument
• variable coat color ranging from yellow, mosaic yellow/agouti, or pseudoagouti

cellular
• sires mated with a/a dams, but not dams mated with a/a sires, that were supplemented with methyl donors ((folate, choline, betaine, vitamin B12, zinc, and methionine) during pregnancy show a significant shift in the spectrum of color phenotypes toward pseudoagouti, indicating that in utero methyl donor supplementation affects the somatic epigenetic state of the Avy allele only when the allele is derived from the male
• F1 pseudoagouti females that had been exposed to methyl donors in utero from E8.5 to E15.5 and mated to a/a males without further methyl donor supplementation, produce offspring (F2) showing a sift toward pseudoagouti coloration, indicating that diet/environment has an enduring influence on succeeding generations, independent of later changes in diet

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:13142 , J:117156




Genotype
MGI:3805305
ht23
Allelic
Composition
am-J/a
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
am-J mutation (1 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• found in both heterozygotes and homozygotes and ranges in color from almost extreme non-agouti with little ticking to full agouti with no mottling

integument
• found in both heterozygotes and homozygotes and ranges in color from almost extreme non-agouti with little ticking to full agouti with no mottling




Genotype
MGI:3778284
ht24
Allelic
Composition
Avy/a
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Avy mutation (7 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation

integument

cellular
• this allele is heavily methylated in the sperm of agouti colored males but hypomethylated in the sperm of yellow males




Genotype
MGI:5444873
ht25
Allelic
Composition
Aw-15J/a
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Aw-15J mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the genetic background indicates the mouse should be non-agouti black however the dorsal coat is agouti
• the ventrum is cream to white not non-agouti black as inferred from the strain background

pigmentation
• the genetic background indicates the mouse should be non-agouti black however the dorsal coat is agouti
• the ventrum is cream to white not non-agouti black as inferred from the strain background




Genotype
MGI:3760281
ht26
Allelic
Composition
Ay/a
Genetic
Background
involves: KK
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• blood glucose levels increase with age in both sexes
• marked hyperglycemia (400-500 mg/dl) develops by 16 weeks of age
• markedly elevated plasma immunoreactive insulin (IRI) level increases with age
• present at all ages tested (5, 10, 16 weeks) and in both sexes
• insulin sensitivity is impaired at 10 weeks and lost by 16 weeks
• lipogenesis from acetate is elevated at 5 weeks of age, the enhanced activity is maintained until 16 weeks of age
• the acetate/glucose ratio is higher than control in young mice

adipose tissue
• adipose tissue weight increases with age, reaching a maximum at 10 weeks of age

growth/size/body
• greater body weight gain occurs in females as compared to black KK controls

endocrine/exocrine glands
• islets are hypertrophic in 10-16 week old mice
• central cavity formation with occasional red blood cells is observed in islets
• beta cells are degranulated
• degranulated islets are infiltrated with fine glycogen granules

renal/urinary system
• present at all ages tested (5, 10, 16 weeks) and in both sexes
• basement membrane of Bowman's capsules is thickened
• some glomeruli exhibit an accumulation of eosinophilic material in the outer parts of the capillary
• mesangial matrix is thickened
• basement membrane of tubules is thickened
• hyaline materials or hyaline cast is present in tubules
• hyaline materials or hyaline cast is present in tubules

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:26460




Genotype
MGI:3789002
ht27
Allelic
Composition
Aw/a
Genetic
Background
involves: SM/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Aw mutation (17 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• total cortex and x-zone of adrenal cortex are of similar thickness to a/a and Aw/ Aw 70-day old virgin mice
• X-zone is composed exclusively of non-vacuolated cells
• 70-day old hybrids of mixed C57BL/6 and SM/J background have non-vacuolated x-zones




Genotype
MGI:5299236
ht28
Allelic
Composition
a/a20H
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
a20H mutation (1 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument

pigmentation




Genotype
MGI:3047815
ht29
Allelic
Composition
ajl41/a
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
ajl41 mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• jet-black appearance is probably equivalent to extreme nonagouti

integument
• jet-black appearance is probably equivalent to extreme nonagouti




Genotype
MGI:3047806
ht30
Allelic
Composition
ajl10/a
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
ajl10 mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• jet-black appearance is probably equivalent to extreme nonagouti

integument
• jet-black appearance is probably equivalent to extreme nonagouti




Genotype
MGI:3047817
ht31
Allelic
Composition
ajl85/a
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
ajl85 mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• jet-black appearance is probably equivalent to extreme nonagouti

integument
• jet-black appearance is probably equivalent to extreme nonagouti




Genotype
MGI:4367209
ht32
Allelic
Composition
a/atwp
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
atwp mutation (0 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have a black dorsum and white ventrum
• mice have a white ventrum, the pattern identical to that seen on at/- mice
• mice have a subtle yellow throat patch

integument
• mice have a black dorsum and white ventrum
• mice have a white ventrum, the pattern identical to that seen on at/- mice
• mice have a subtle yellow throat patch




Genotype
MGI:3805043
cx33
Allelic
Composition
a/a
Hps6ru/Hps6ru
Genetic
Background
B6.Cg-Hps6ru
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Hps6ru mutation (6 available); any Hps6 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• platelet ADP levels are much lower than in C57BL/6J controls
• platelet ATP levels are much lower than in C57BL/6J controls
• fewer platelet dense granules than normal
• less than 7% of normal levels of platelet serotonin (J:7327)
• platelet serotonin level is also lower than that of control when fed an atherogenic diet (J:29748)

homeostasis/metabolism
• less than 7% of normal levels of platelet serotonin (J:7327)
• platelet serotonin level is also lower than that of control when fed an atherogenic diet (J:29748)
• bleed time averaging over 15 minutes after tail nick is much greater than the 3.8 minutes for C57BL/6J controls

cardiovascular system
• on an atherogenic diet homozygotes develop fewer aortic lesions and smaller lesions than C57BL/6J controls
• 60% of homozygotes survive to 48 weeks of age on an atherogenic diet, when no C57BL/6J controls survive, and, although there are significant atherosclerotic lesions in these 48 week old homozygotes, the lesions are smaller than those in 39 week old C57BL/6J controls fed the atherogenic diet

integument

pigmentation

nervous system
• the ipsilateral lateral geniculate nucleus has fewer projections from the retinal ganglion cells
• there is a reduced number of projections of retinal ganglion cells to the ipsilateral lateral geniculate nucleus

vision/eye
• there is a reduced number of projections of retinal ganglion cells to the ipsilateral lateral geniculate nucleus

renal/urinary system
• concentration of lysosomal enzymes is elevated
• decreased rate of secretion of lysosomal enzyme into urine




Genotype
MGI:3813609
cx34
Allelic
Composition
a/a
KitW-2J/Kit+
Genetic
Background
C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
KitW-2J mutation (5 available); any Kit mutation (133 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• about 75% of the coat is pigmented on this background

integument
• about 75% of the coat is pigmented on this background




Genotype
MGI:5609871
cx35
Allelic
Composition
Ay/a
Sik2tm1Htake/Sik2+
Genetic
Background
C57BL/6-Sik2tm1Htake
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Sik2tm1Htake mutation (0 available); any Sik2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• slightly darker than in Ay/a mice on the dorsal region
• darker ventral region hair compared with Ay/a mice

pigmentation
• slightly darker than in Ay/a mice on the dorsal region
• darker ventral region hair compared with Ay/a mice




Genotype
MGI:3052536
cx36
Allelic
Composition
a/a
Mlphln/Mlphln
Tyrp1b/Tyrp1b
Genetic
Background
C57L/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mlphln mutation (14 available); any Mlph mutation (26 available)
Tyrp1b mutation (97 available); any Tyrp1 mutation (164 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• due to clumping of pigment
• results in clumping rather than even distribution of pigment during hair development

integument
• due to clumping of pigment




Genotype
MGI:5766498
cx37
Allelic
Composition
A/a
In(11Trp53;11Wnt3)8Brd/+
Genetic
Background
either: (involves: 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6Brd) or (involves: 129S5/SvEvBrd * C57BL/6Brd * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
A mutation (23 available); any a mutation (364 available)
In(11Trp53;11Wnt3)8Brd mutation (2 available); any In(11Trp53;11Wnt3)8Brd mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

growth/size/body
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

hearing/vestibular/ear
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.

integument
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

limbs/digits/tail
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

pigmentation
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored ears due to the Krt14-A transgene in the Wnt3 locus.
• mice heterozygous for this inversion on an agouti background have agouti hair coats, but with light-colored tails due to the Krt14-A transgene in the Wnt3 locus.




Genotype
MGI:5636497
cx38
Allelic
Composition
a/a
Pax3Sp-1H/Pax3Sp-1H
Genetic
Background
involves: 101/H * C3H/HeH * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Pax3Sp-1H mutation (1 available); any Pax3 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• in half of E13.5 embryos examined, parts of the rostral neural tube are not closed properly

nervous system
• in half of E13.5 embryos examined, parts of the rostral neural tube are not closed properly
• in some mutants the rostral nueral tube does not close leaving the hindbrain, midbrain, and most of the forebrain exposed
• incomplete closure of anterior neuropore leads to collapse of lateral ventricles
• noted in lateral ventricles of E16.5 fetuses
• E16.5 fetuses do not show lamination in the cerebral cortex
• noted at E16.5 of gestation




Genotype
MGI:5297861
cx39
Allelic
Composition
Ay/a
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Mae/Ccr2tm1Mae
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Apoetm1Unc mutation (22 available); any Apoe mutation (68 available)
Ay mutation (10 available); any a mutation (364 available)
Ccr2tm1Mae mutation (2 available); any Ccr2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mutants are protected against the metabolic syndrome, atherosclerosis, and diabetic nephropathy that develops in Ay/a Apoetm1Unc double mutants




Genotype
MGI:5297860
cx40
Allelic
Composition
Ay/a
Apoetm1Unc/Apoetm1Unc
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Apoetm1Unc mutation (22 available); any Apoe mutation (68 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mutants develop larger atherosclerotic plaques than a/a Apoetm1Unc/Apoetm1Unc mice
• plaques contain a higher proportion of macrophage infiltration

growth/size/body
• mutants exhibit increased weight gain, despite similar food intake as controls

hematopoietic system
• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads

homeostasis/metabolism

immune system
• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads
• increase in systemic inflammation

renal/urinary system
• mutants develop features of diabetic nephropathy
• mutants exhibit mesangial expansion as indicated by glycogen deposition in the glomeruli
• 20-30% of mutants exhibit nodular sclerosis in the kidney




Genotype
MGI:3778273
cx41
Allelic
Composition
Avy/a
Axin1Fu/Axin1+
Genetic
Background
involves: 129P4/RrRk * C67BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Avy mutation (7 available); any a mutation (364 available)
Axin1Fu mutation (1 available); any Axin1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• penetrance of fused and viable yellow are independent of each other with double heterozygotes displaying all combinations of coat color and tail phenotypes due to independent variations in penetrance of each




Genotype
MGI:3526898
cx42
Allelic
Composition
Ay/a
Npbwr1tm1Rck/Npbwr1tm1Rck
Genetic
Background
involves: 129P/Ola * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Npbwr1tm1Rck mutation (0 available); any Npbwr1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• male double homozygotes were more obese than heterozygous Ay males whereas females weighted the same as heterozygous Ay females




Genotype
MGI:3776093
cx43
Allelic
Composition
Ay/a
Agrptm2(DTR)Rpa/Agrp+
Genetic
Background
involves: 129S4/SvJaeSor * KK/Upj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Agrptm2(DTR)Rpa mutation (0 available); any Agrp mutation (10 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells

growth/size/body
• in mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells




Genotype
MGI:3805940
cx44
Allelic
Composition
a/A
Pomctm1Sora/Pomctm1Sora
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
A mutation (23 available); any a mutation (364 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have a slightly more yellow coat than agouti controls
• the phaeomelanin to total melanin ratio is higher (0.30) than in agouti controls (0.19)

integument
• mice have a slightly more yellow coat than agouti controls
• the phaeomelanin to total melanin ratio is higher (0.30) than in agouti controls (0.19)




Genotype
MGI:3805943
cx45
Allelic
Composition
a/a
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6Ha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mc1re mutation (6 available); any Mc1r mutation (24 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (9 available)
Tg(MC1R)1Jkn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have a much more yellow coat than agouti controls
• the phaeomelanin to total melanin ratio is higher (1.74) than in controls (0.20)

integument
• mice have a much more yellow coat than agouti controls
• the phaeomelanin to total melanin ratio is higher (1.74) than in controls (0.20)




Genotype
MGI:3805942
cx46
Allelic
Composition
a/A
Mc1re/Mc1re
Pomctm1Sora/Pomctm1Sora
Tg(MC1R)1Jkn/?
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6Ha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
A mutation (23 available); any a mutation (364 available)
Mc1re mutation (6 available); any Mc1r mutation (24 available)
Pomctm1Sora mutation (0 available); any Pomc mutation (9 available)
Tg(MC1R)1Jkn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have a much more yellow coat than agouti controls
• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)

integument
• mice have a much more yellow coat than agouti controls
• the phaeomelanin to total melanin ratio is higher (2.00) than in agouti controls (0.19)




Genotype
MGI:5766500
cx47
Allelic
Composition
a/a
In(11Trp53;11Wnt3)8Brd/+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6Brd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
In(11Trp53;11Wnt3)8Brd mutation (2 available); any In(11Trp53;11Wnt3)8Brd mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mice heterozygous for this inversion on a black, non-agouti background are recognizable by their light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

limbs/digits/tail
• mice heterozygous for this inversion on a black, non-agouti background are recognizable by their light-colored tails due to the Krt14-A transgene in the Wnt3 locus.

pigmentation
• mice heterozygous for this inversion on a black, non-agouti background are recognizable by their light-colored tails due to the Krt14-A transgene in the Wnt3 locus.




Genotype
MGI:3772887
cx48
Allelic
Composition
Aw/a
Corintm1Bamo/Corintm1Bamo
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Aw mutation (17 available); any a mutation (364 available)
Corintm1Bamo mutation (0 available); any Corin mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice exhibit a progressively lighter coat color with additional functioning non-agouti allele
• Background Sensitivity: authors state that mice on a 129 or FVB background for more than 6 generation exhibit a qualitatively similar phenotype

integument
• mice exhibit a progressively lighter coat color with additional functioning non-agouti allele
• Background Sensitivity: authors state that mice on a 129 or FVB background for more than 6 generation exhibit a qualitatively similar phenotype




Genotype
MGI:3772889
cx49
Allelic
Composition
a/a
Corintm1Bamo/Corintm1Bamo
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Corintm1Bamo mutation (0 available); any Corin mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• mice exhibit normal black coat color
• Background Sensitivity: authors state that mice on a C57BL/6 background for more than 6 generation exhibit a qualitatively similar phenotype




Genotype
MGI:5763608
cx50
Allelic
Composition
a/a
DctSlt-lt/DctSlt-lt
Genetic
Background
involves: C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
DctSlt-lt mutation (1 available); any Dct mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• on a non-agouti background, the fur of mice homozygous for DctSlt-lt is light brown.

pigmentation
• on a non-agouti background, the fur of mice homozygous for DctSlt-lt is light brown.




Genotype
MGI:5763609
cx51
Allelic
Composition
a/a
DctSlt-lt/Dct+
Genetic
Background
involves: C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
DctSlt-lt mutation (1 available); any Dct mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• on a non-agouti background, the coat color of mice heterozygous for DctSlt-lt is dark brown, closely resembling that of Dctslt/Dctslt or Dctslt/DctSlt-lt mice.

pigmentation
• on a non-agouti background, the coat color of mice heterozygous for DctSlt-lt is dark brown, closely resembling that of Dctslt/Dctslt or Dctslt/DctSlt-lt mice.




Genotype
MGI:4454423
cx52
Allelic
Composition
a/a
Oca2p-J/Oca2p-J
Genetic
Background
involves: C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Oca2p-J mutation (4 available); any Oca2 mutation (83 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• reorganization of fibrillar melanosomes into particulate melanin granules, such that only 20% of melanosomes in adult retina are fibrillar in nature, the rest are particulate
• 2% of premelanosomes in the choroid are fused to form giant granules
• premature termination of melanization of the premelanosome filaments in the retina

vision/eye
• 2% of premelanosomes in the choroid are fused to form giant granules




Genotype
MGI:4454430
cx53
Allelic
Composition
a/a
Lystbg/Lystbg
Oca2p-J/Oca2p-J
Genetic
Background
involves: C3H/HeJ * C3H/Rl * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Lystbg mutation (5 available); any Lyst mutation (109 available)
Oca2p-J mutation (4 available); any Oca2 mutation (83 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• reorganization of fibrillar melanosomes into particulate melanin granules, such that only 35% of melanosomes in adult retina are fibrillar in nature, the rest are particulate
• 2% of premelanosomes in the choroid are fused to form giant granules

vision/eye
• 2% of premelanosomes in the choroid are fused to form giant granules




Genotype
MGI:5505784
cx54
Allelic
Composition
a/a
Rab27aash/Rab27aash
Genetic
Background
involves: C3H/HeSnJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Rab27aash mutation (3 available); any Rab27a mutation (134 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• Background Sensitivity: platelet-dense granules and platelet coagulation are normal or near normal unlike on the C3H/HeSnJ background
• Background Sensitivity: concentrations of adenine nucleotides, ADP and ATP, of platelets are only nominally lower than controls and are not significantly different from controls compared to on the C3H/HeSnJ background where levels are depressed
• Background Sensitivity: platelet-dense granule serotonin levels are somewhat depressed in platelets compared to wild-type, but levels are much greater than on the C3H/HeSnJ background

homeostasis/metabolism
• Background Sensitivity: platelet-dense granule serotonin levels are somewhat depressed in platelets compared to wild-type, but levels are much greater than on the C3H/HeSnJ background
• Background Sensitivity: modest increase in bleeding time to 6.9 minutes from the normal 2.7 minutes, but shorter than on the C3H/HeSnJ background

Mouse Models of Human Disease
OMIM ID Ref(s)
Griscelli Syndrome, Type 2; GS2 607624 J:77395




Genotype
MGI:4454429
cx55
Allelic
Composition
a/a
Lystbg/Lystbg
Tyrc/Tyrc
Genetic
Background
involves: C3H/Rl * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Lystbg mutation (5 available); any Lyst mutation (109 available)
Tyrc mutation (138 available); any Tyr mutation (366 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• absence of fibrillar melanosomes in the choroid and retina
• number of granules diminishes in adults after birth
• number of granules diminishes in adults after birth
• absence of melanin deposition on premelanosome filaments

vision/eye
• number of granules diminishes in adults after birth
• number of granules diminishes in adults after birth




Genotype
MGI:4454432
cx56
Allelic
Composition
a/a
Lystbg/Lystbg
Tyrp1b/Tyrp1b
Genetic
Background
involves: C3H/Rl * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Lystbg mutation (5 available); any Lyst mutation (109 available)
Tyrp1b mutation (97 available); any Tyrp1 mutation (164 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• 80% of premelanosomes in the choroid and retina fuse to form giant granules
• 80% of premelanosomes in the choroid and retina fuse to form giant granules

vision/eye
• 80% of premelanosomes in the choroid and retina fuse to form giant granules
• 80% of premelanosomes in the choroid and retina fuse to form giant granules




Genotype
MGI:4454426
cx57
Allelic
Composition
a/a
Lystbg/Lystbg
Genetic
Background
involves: C3H/Rl * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Lystbg mutation (5 available); any Lyst mutation (109 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• 80% of premelanosomes in the choroid and retina are fused to form giant granules
• 80% of premelanosomes in the retina and choroid are fused to form giant granules

vision/eye
• 80% of premelanosomes in the choroid and retina are fused to form giant granules
• 80% of premelanosomes in the retina and choroid are fused to form giant granules




Genotype
MGI:4454431
cx58
Allelic
Composition
a/a
Hps6ru/Hps6ru
Lystbg/Lystbg
Genetic
Background
involves: C3H/Rl * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Hps6ru mutation (6 available); any Hps6 mutation (17 available)
Lystbg mutation (5 available); any Lyst mutation (109 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• reorganization of fibrillar melanosomes into particulate melanin granules, such that only 5% of melanosomes in the choroid and 60% in the retina are fibrillar in nature, the rest are particulate
• 80% of premelanosomes in the retina are fused to form giant premelanosomes
• premelanosome formation in the choroid is delayed until after birth

vision/eye
• 80% of premelanosomes in the retina are fused to form giant premelanosomes




Genotype
MGI:4454424
cx59
Allelic
Composition
a/a
Hps6ru/Hps6ru
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Hps6ru mutation (6 available); any Hps6 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• reorganization of fibrillar melanosomes into particulate melanin granules, such that only 5% of melanosomes in the choroid and 50% in the retina are fibrillar in nature, the rest are particulate
• premelanosome formation and the subsequent deposition of melanin in the choroid is delayed until after birth
• decrease in the melanization of pigment granules

vision/eye




Genotype
MGI:4454434
cx60
Allelic
Composition
a/a
Bloc1s6pa/Bloc1s6pa
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Bloc1s6pa mutation (11 available); any Bloc1s6 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• number of granules in the retina is greatly reduced
• size of granules is diminished

vision/eye
• number of granules in the retina is greatly reduced
• size of granules is diminished




Genotype
MGI:5466757
cx61
Allelic
Composition
a/a
Mregdsu/Mregdsu
Hps6ru/Hps6ru
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Hps6ru mutation (6 available); any Hps6 mutation (17 available)
Mregdsu mutation (1 available); any Mreg mutation (94 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• products of this genotype normalize eye color from ruby to wild-type black
• coat color dilution is not affected

integument
• coat color dilution is not affected by the dilute repressor mutation, Mregdsu
• the wild-type nonagouti black coat is diluted to a dull reddish brown

pigmentation
• coat color dilution is not affected by the dilute repressor mutation, Mregdsu
• the wild-type nonagouti black coat is diluted to a dull reddish brown




Genotype
MGI:4454419
cx62
Allelic
Composition
a/a
Tyrc/Tyrc
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Tyrc mutation (138 available); any Tyr mutation (366 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• premelanosomes form normally but melanin is not deposited on the filaments and they never mature and eventually disappear in the retina




Genotype
MGI:4454425
cx63
Allelic
Composition
a/a
Tyrp1b/Tyrp1b
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Tyrp1b mutation (97 available); any Tyrp1 mutation (164 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• reorganization of fibrillar melanosomes into particulate melanin granules, such that 20% of granules in the choroid are particulate




Genotype
MGI:3833969
cx64
Allelic
Composition
Ay/a
Mssq9C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq9C57BL/6JJcl mutation (0 available); any Mssq9 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833436
cx65
Allelic
Composition
Ay/a
Mssq1KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq1KK/TaJcl mutation (0 available); any Mssq1 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833437
cx66
Allelic
Composition
a/a
Mssq1KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq1KK/TaJcl mutation (0 available); any Mssq1 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833439
cx67
Allelic
Composition
Ay/a
Mssq2C57BL/6JJcl/Mssq2KK/TaJcl
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq2C57BL/6JJcl mutation (0 available); any Mssq2 mutation (0 available)
Mssq2KK/TaJcl mutation (0 available); any Mssq2 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833448
cx68
Allelic
Composition
Ay/a
Mssq3KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq3KK/TaJcl mutation (0 available); any Mssq3 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833451
cx69
Allelic
Composition
a/a
Mssq3KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq3KK/TaJcl mutation (0 available); any Mssq3 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833452
cx70
Allelic
Composition
Ay/a
Mssq4KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq4KK/TaJcl mutation (0 available); any Mssq4 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833453
cx71
Allelic
Composition
a/a
Mssq4KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq4KK/TaJcl mutation (0 available); any Mssq4 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833454
cx72
Allelic
Composition
Ay/a
Mssq5C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq5C57BL/6JJcl mutation (0 available); any Mssq5 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833455
cx73
Allelic
Composition
a/a
Mssq5C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq5C57BL/6JJcl mutation (0 available); any Mssq5 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833456
cx74
Allelic
Composition
Ay/a
Mssq6C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq6C57BL/6JJcl mutation (0 available); any Mssq6 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for principal component analysis of mandible size

skeleton
• increased values for principal component analysis of mandible size




Genotype
MGI:3833457
cx75
Allelic
Composition
a/a
Mssq6C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq6C57BL/6JJcl mutation (0 available); any Mssq6 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for pricipal component analysis of mandible size

skeleton
• increased values for pricipal component analysis of mandible size




Genotype
MGI:3833460
cx76
Allelic
Composition
Ay/a
Mssq6KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq6KK/TaJcl mutation (0 available); any Mssq6 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833461
cx77
Allelic
Composition
a/a
Mssq6KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq6KK/TaJcl mutation (0 available); any Mssq6 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833471
cx78
Allelic
Composition
Ay/a
Mssq7KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq7KK/TaJcl mutation (0 available); any Mssq7 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833472
cx79
Allelic
Composition
a/a
Mssq7KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq7KK/TaJcl mutation (0 available); any Mssq7 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833967
cx80
Allelic
Composition
a/a
Mssq8C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq8C57BL/6JJcl mutation (0 available); any Mssq8 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for principal component analysis of mandible size

skeleton
• increased values for principal component analysis of mandible size




Genotype
MGI:3833968
cx81
Allelic
Composition
a/a
Mssq9C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq9C57BL/6JJcl mutation (0 available); any Mssq9 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833970
cx82
Allelic
Composition
a/a
Mssq10KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq10KK/TaJcl mutation (0 available); any Mssq10 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833971
cx83
Allelic
Composition
Ay/a
Mssq10KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq10KK/TaJcl mutation (0 available); any Mssq10 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833972
cx84
Allelic
Composition
a/a
Mssq11KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq11KK/TaJcl mutation (0 available); any Mssq11 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for principal component analysis of mandible size measurements

skeleton
• increased values for principal component analysis of mandible size measurements




Genotype
MGI:3833973
cx85
Allelic
Composition
Ay/a
Mssq11KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq11KK/TaJcl mutation (0 available); any Mssq11 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for principal component analysis of mandible size measurements

skeleton
• increased values for principal component analysis of mandible size measurements




Genotype
MGI:3833974
cx86
Allelic
Composition
a/a
Mssq12KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq12KK/TaJcl mutation (0 available); any Mssq12 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for principal component analysis of mandible size measurements

skeleton
• increased values for principal component analysis of mandible size measurements




Genotype
MGI:3833975
cx87
Allelic
Composition
Ay/a
Mssq12KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq12KK/TaJcl mutation (0 available); any Mssq12 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for principal component analysis of mandible size measurements

skeleton
• increased values for principal component analysis of mandible size measurements




Genotype
MGI:3833976
cx88
Allelic
Composition
a/a
Mssq13KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq13KK/TaJcl mutation (0 available); any Mssq13 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for principal component analysis of mandible size measurements

skeleton
• increased values for principal component analysis of mandible size measurements




Genotype
MGI:3833977
cx89
Allelic
Composition
Ay/a
Mssq13KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq13KK/TaJcl mutation (0 available); any Mssq13 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for principal component analysis of mandible size measurements

skeleton
• increased values for principal component analysis of mandible size measurements




Genotype
MGI:3833978
cx90
Allelic
Composition
a/a
Mssq13C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq13C57BL/6JJcl mutation (0 available); any Mssq13 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833979
cx91
Allelic
Composition
Ay/a
Mssq13C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq13C57BL/6JJcl mutation (0 available); any Mssq13 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833980
cx92
Allelic
Composition
a/a
Mssq14KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq14KK/TaJcl mutation (0 available); any Mssq14 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size
• increased values for principal component analysis of mandible size measurements

skeleton
• increased mandible size
• increased values for principal component analysis of mandible size measurements




Genotype
MGI:3833981
cx93
Allelic
Composition
Ay/a
Mssq14KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq14KK/TaJcl mutation (0 available); any Mssq14 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size
• increased values for principal component analysis of mandible size measurements

skeleton
• increased mandible size
• increased values for principal component analysis of mandible size measurements




Genotype
MGI:3833982
cx94
Allelic
Composition
a/a
Mssq15C57BL/6JJcl/Mssq15KK/TaJcl
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq15C57BL/6JJcl mutation (0 available); any Mssq15 mutation (0 available)
Mssq15KK/TaJcl mutation (0 available); any Mssq15 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833983
cx95
Allelic
Composition
a/a
Mssq16KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mssq16KK/TaJcl mutation (0 available); any Mssq16 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833984
cx96
Allelic
Composition
Ay/a
Mssq16KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq16KK/TaJcl mutation (0 available); any Mssq16 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:2175418
cx97
Allelic
Composition
a/a
Zc3h4KK/Zc3h4KK
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Zc3h4KK mutation (0 available); any Zc3h4 mutation (154 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body




Genotype
MGI:3773903
cx98
Allelic
Composition
a/Ay
Guq2C57BL/6J/Guq2C57BL/6J
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Guq2C57BL/6J mutation (0 available); any Guq2 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increased glucosuria severity at 40 days of age

renal/urinary system
• increased glucosuria severity at 40 days of age




Genotype
MGI:3773901
cx99
Allelic
Composition
a/Ay
Bwq10C57BL/6J/Bwq10C57BL/6J
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Bwq10C57BL/6J mutation (0 available); any Bwq10 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• increased body weight at 40, 50, and 60 days of age




Genotype
MGI:3487268
cx100
Allelic
Composition
a/Ay
Bwq2KK/Bwq2KK
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Bwq2KK mutation (0 available); any Bwq2 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• increased body weight at 40-100 days of age (J:93199)
• increased body weight at 40, 50, and 60 days of age (J:131439)
• increased weight gain at 30-40 days of age




Genotype
MGI:2679981
cx101
Allelic
Composition
a/Ay
Zc3h4C57BL/6J/Zc3h4KK
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Zc3h4C57BL/6J mutation (0 available); any Zc3h4 mutation (154 available)
Zc3h4KK mutation (0 available); any Zc3h4 mutation (154 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• increased body weight




Genotype
MGI:2679980
cx102
Allelic
Composition
a/Ay
Zc3h4KK/Zc3h4KK
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Zc3h4KK mutation (0 available); any Zc3h4 mutation (154 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body




Genotype
MGI:3773902
cx103
Allelic
Composition
a/Ay
Guq1KK/Guq1KK
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Guq1KK mutation (0 available); any Guq1 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increased glucosuria severity at 40 days of age

renal/urinary system
• increased glucosuria severity at 40 days of age




Genotype
MGI:4936833
cx104
Allelic
Composition
Ay/a
Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic
Background
involves: C57BL/6 * KK
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Rmi1Gt(pUHachi)0283Imeg mutation (0 available); any Rmi1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• compared with Ay/a mice

homeostasis/metabolism
• compared with Ay/a mice
• compared with Ay/a mice

behavior/neurological
• compared with Ay/a mice

liver/biliary system
• compared with Ay/a mice

adipose tissue
N
• mice exhibit normal intra-abdominal fat




Genotype
MGI:4936834
cx105
Allelic
Composition
a/a
Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic
Background
involves: C57BL/6 * KK
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Rmi1Gt(pUHachi)0283Imeg mutation (0 available); any Rmi1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• compared with a/a homozygotes

homeostasis/metabolism
• compared with a/a homozygotes
• compared with a/a homozygotes

liver/biliary system
• compared with a/a homozygotes

adipose tissue
• compared with a/a homozygotes

behavior/neurological
N
• mice exhibit normal food intake




Genotype
MGI:4454435
cx106
Allelic
Composition
a/a
Mlphln/Mlphln
Genetic
Background
involves: C57BL/J * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Mlphln mutation (14 available); any Mlph mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have clumped granules in the hair and skin
• granules tend to clump in the choroid but not in the retina

vision/eye
• granules tend to clump in the choroid but not in the retina

integument
• mice have clumped granules in the hair and skin




Genotype
MGI:3795191
cx107
Allelic
Composition
a/a
Myo5ad/Myo5a+
Oca2p/Oca2+
Tyrp1B-lt/Tyrp1+
Genetic
Background
involves: C58 * CT/Ch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Myo5ad mutation (127 available); any Myo5a mutation (199 available)
Oca2p mutation (15 available); any Oca2 mutation (83 available)
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (164 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment

integument
• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment




Genotype
MGI:4454433
cx108
Allelic
Composition
a/a
Myo5ad/Myo5ad
Genetic
Background
involves: DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Myo5ad mutation (127 available); any Myo5a mutation (199 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have clumped granules in the hair and skin
• granules tend to clump in the choroid but not in the retina

vision/eye
• granules tend to clump in the choroid but not in the retina

integument
• mice have clumped granules in the hair and skin




Genotype
MGI:3759412
cx109
Allelic
Composition
Ay/a
Dmbx1tm1Sse/Dmbx1tm1Sse
Genetic
Background
involves: ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Dmbx1tm1Sse mutation (0 available); any Dmbx1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• unlike Ay/a mice, the body weight of double homozygotes is similar to that of Dmbx1 homozygotes




Genotype
MGI:2663195
cx110
Allelic
Composition
a/a
Tyrc-i/Tyrc-i
Genetic
Background
involves: STOCK Tyrc-r
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Tyrc-i mutation (0 available); any Tyr mutation (366 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• yellow pigment is pale, nearly lemon tint; the nonagouti type is indistinguishable from ordinary nonagouti or black
• black pigment is very slightly reduced, but coat appears black

integument
• yellow pigment is pale, nearly lemon tint; the nonagouti type is indistinguishable from ordinary nonagouti or black
• black pigment is very slightly reduced, but coat appears black