Mreg^dsu
Spontaneous Allele Detail

Summary

• Symbol: Mreg^dsu
• Name: melanoregulin; dilute suppressor
• MGI ID: MGI:1856847
• Synonyms: dsu
• Gene: Mreg Location: Chr1:72198601-72251466 bp, - strand Genetic Position: Chr1, 36.39 cM
• Alliance: Mreg^dsu page

Myo5a^d/ Myo5a^d and Myo5a^d/ Myo5a^d Mreg^dsu/ Mreg^dsu

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: STOCK a Myo5a^d Hephl1^cw

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: Genomic PCR and DNA sequencing analysis showed the mutation is a deletion that spans the region from 11.1-kb upstream of the initiator methionine to intron 2. Northern and RT-PCR analysis demonstrated that no wild-type transcript could be detected in the mutant animals. Western blot analysis of homozygous mutant melanocytes showed that it also is not expressed at the protein level. (J:94728)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mreg Mutation: 103 strains or lines available

References

• Original: J:7171 Sweet HO, Dilute suppressor, a new suppressor gene in the house mouse. J Hered. 1983 Jul-Aug;74(4):305-6
• All: 12 reference(s)