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Mreg Gene Detail
Summary
  • Symbol
    Mreg
  • Name
    melanoregulin
  • Synonyms
    dsu, LOC381269, Wdt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151839
    NCBI Gene: 381269
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:72198601-72251466 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 36.39 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1848 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151839
 protein coding gene Chr1:72198392-72251466 (-)
129S1/SvImJ ENSMUSG00200004385
 protein coding gene Chr1:69856990-69909911 (-)
A/J ENSMUSG00195029710
 protein coding gene Chr1:69274717-69328517 (-)
AKR/J ENSMUSG00220034074
 protein coding gene Chr1:69428405-69480856 (-)
BALB/cJ ENSMUSG00180030169
 protein coding gene Chr1:69539347-69592234 (-)
C3H/HeJ ENSMUSG00175000783
 protein coding gene Chr1:69670084-69723873 (-)
C57BL/6NJ ENSMUSG00215020642
 protein coding gene Chr1:69585183-69638057 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014240
 protein coding gene Chr1:65768601-65823671 (-)
CAST/EiJ ENSTCUG00005020261
 protein coding gene Chr1:69339296-69394077 (-)
CBA/J ENSMUSG00210002984
 protein coding gene Chr1:69367337-69420226 (-)
DBA/2J ENSMUSG00185004887
 protein coding gene Chr1:70457908-70510788 (-)
FVB/NJ ENSMUSG00205011494
 protein coding gene Chr1:69093968-69146844 (-)
JF1/MsJ ENSUMUG00000003859
 protein coding gene Chr1:69360478-69416642 (-)
LP/J ENSMUSG00230001624
 protein coding gene Chr1:70452113-70505038 (-)
NOD/ShiLtJ ENSMUSG00190013586
 protein coding gene Chr1:69584221-69637089 (-)
NZO/HlLtJ ENSMUSG00225040193
 protein coding gene Chr1:73667265-73720143 (-)
PWK/PhJ ENSLUMG00010007192
 protein coding gene Chr1:68959639-69015747 (-)
SPRET/EiJ ENSMSPG00010017374
 protein coding gene Chr1:71043234-71097102 (-)
WSB/EiJ ENSIUOG00005026718
 protein coding gene Chr1:69222671-69276017 (-)



Homology
more
  • Human Ortholog
    MREG, melanoregulin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MREG, melanoregulin
  • Synonyms
    DSU, WDT2
  • Links
    NCBI Gene ID: 55686
    UniProt: Q8N565

  • Chr Location
    2q35; chr2:215939308-216034096 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    3 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A spontaneous suppressor mutation restores normal melanocyte morphology and therefore coat color in mutations producing coat color dilution.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    19
  • cDNA Data
    24
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039395 Ensembl Gene Model | MGI Sequence Detail 52866 C57BL/6J ±  kb
    transcript ENSMUST00000048860 Ensembl | MGI Sequence Detail 2284 Not Applicable  
    polypeptide ENSMUSP00000041878 Ensembl | MGI Sequence Detail 214 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 24
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-8909, MGI:2685820, MGI:94933
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 13
      Phenotypes 32
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:390780 Qasrawi F, et al., DeltaNP63 regulates epithelial stratification and differentiation in the murine ureter. Am J Physiol Renal Physiol. 2026 Aug 1;331(2):F286-F303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory