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Targeted Allele Detail
Symbol: Atm1Brd
Name: nonagouti; targeted mutation 1, Allan Bradley
MGI ID: MGI:3842513
Gene: a  Location: Chr2:154792519-154892932 bp, + strand  Genetic Position: Chr2, 76.83 cM
Alliance: Atm1Brd page
Germline Transmission:  Earliest citation of germline transmission: J:149352
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Allele Type:    Targeted (No functional change)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis mutation deletes the 11.8 kb retrotransposon insertion responsible for the nonagouti phenotype of C57BL/6 mice, along with 607 bp of flanking intronic DNA, with retention of a single frt site from an excised frt-flanked selection cassette. It restores expression of the agouti protein in both dorsal and ventral fur. (J:149352)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1682 strains available      Cell Lines: 7672 lines available
Carrying any a Mutation:  459 strains or lines available
Although spontaneous revertants of non-agouti retain part of the inserted sequence present in the a allele and are white- or light-bellied agouti (Aw-like), the targeting event that produced Atm1Brd removed the entire insertion, resulting in a fully agouti coat like that of mice bearing the A allele.
Original:  J:149352 Pettitt SJ, et al., Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods. 2009 Jun 14;:1-3
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory