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Targeted Allele Detail
Symbol: Ccr2tm1Mae
Name: C-C motif chemokine receptor 2; targeted mutation 1, Nobuyo Maeda
MGI ID: MGI:2158345
Synonyms: CCR2-, Ccr2tm1Unc
Gene: Ccr2  Location: Chr9:123901987-123913594 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Alliance: Ccr2tm1Mae page
Germline Transmission:  Earliest citation of germline transmission: J:44561
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted in reverse transcriptional orientation in front of the coding sequence for the first transmembrane domain of the encoded protein. Competitive binding assays demonstrated a reduction in specific binding of labeled ligand to peritoneal exudate cells derived from homozygous mice. (J:44561)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ccr2 Mutation:  40 strains or lines available
Original:  J:44561 Kuziel WA, et al., Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12053-8
All:  154 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory