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Fgf8 Gene Detail
Summary
  • Symbol
    Fgf8
  • Name
    fibroblast growth factor 8
  • Synonyms
    Aigf, Fgf-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:99604
    NCBI Gene: 14179
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:45725237-45731354 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.75 cM, cytoband C3-D
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99604
 protein coding gene Chr19:45724930-45731380 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025191
 protein coding gene Chr19:45357781-45363908 (-)
A/J MGP_AJ_G0025168
 protein coding gene Chr19:43140927-43147054 (-)
AKR/J MGP_AKRJ_G0025136
 protein coding gene Chr19:44529755-44535882 (-)
BALB/cJ MGP_BALBcJ_G0025162
 protein coding gene Chr19:43193677-43199804 (-)
C3H/HeJ MGP_C3HHeJ_G0024922
 protein coding gene Chr19:44706956-44713083 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025605
 protein coding gene Chr19:46491248-46497365 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023019
 protein coding gene Chr19:42385544-42391675 (-)
CAST/EiJ MGP_CASTEiJ_G0024387
 protein coding gene Chr19:44459466-44465607 (-)
CBA/J MGP_CBAJ_G0024902
 protein coding gene Chr19:48825047-48831136 (-)
DBA/2J MGP_DBA2J_G0025034
 protein coding gene Chr19:42948610-42954737 (-)
FVB/NJ MGP_FVBNJ_G0024995
 protein coding gene Chr19:42740115-42746242 (-)
LP/J MGP_LPJ_G0025120
 protein coding gene Chr19:45271943-45278070 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025026
 protein coding gene Chr19:48153584-48159711 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025663
 protein coding gene Chr19:44611843-44617970 (-)
PWK/PhJ MGP_PWKPhJ_G0024136
 protein coding gene Chr19:42881259-42887379 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023940
 protein coding gene Chr19:43302902-43309030 (-)
WSB/EiJ MGP_WSBEiJ_G0024457
 protein coding gene Chr19:44769831-44775961 (-)



Homology
more
  • Human Ortholog
    FGF8, fibroblast growth factor 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF8, fibroblast growth factor 8
  • Synonyms
    AIGF, FGF-8, HBGF-8, HH6, KAL6
  • Links
    NCBI Gene ID: 2253
    neXtProt AC: NX_P55075
    UniProt: P55075

  • Chr Location
    10q24.32; chr10:101770109-101780371 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Fgf8 mouse models; 2 with human FGF8 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    164 phenotypes from 15 alleles in 20 genetic backgrounds
    77 phenotypes from multigenic genotypes
    1 images
    160 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit cardiovascular defects (including abnormal left-right axis determination), impaired limb, thymic, and craniofacial development, and prenatal or early postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    132
  • GO References
    43
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    3281
  • Tissues
    683
  • cDNA Data
    62
  • Literature Summary
    1129
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025219 Ensembl Gene Model | MGI Sequence Detail 6118 C57BL/6J ±  kb
    transcript ENSMUST00000026241 Ensembl | MGI Sequence Detail 1168 Not Applicable  
    polypeptide ENSMUSP00000026241 Ensembl | MGI Sequence Detail 268 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 283
      Genomic 6
      cDNA 77
      Primer pair 37
      Other 163

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1237, MGD-MRK-16389
    References
    more
    • Summaries
      All 1283
      Developmental Gene Expression 1129
      Diseases 2
      Gene Ontology 43
      Phenotypes 160
    • Earliest
      J:2935 Tanaka A, et al., Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8928-32
    • Latest
      J:346456 Lozovska A, et al., Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape. Nat Commun. 2024 Mar 20;15(1):2509
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory