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Tmem94 Gene Detail
Summary
  • Symbol
    Tmem94
  • Name
    transmembrane protein 94
  • Synonyms
    2310067B10Rik, mKIAA0195
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919197
    NCBI Gene: 71947
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115656245-115689859 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919197
protein coding gene Chr11:115656245-115690192 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019399
protein coding gene Chr11:119829140-119866033 (+)
A/J MGP_AJ_G0019368
protein coding gene Chr11:114591032-114623241 (+)
AKR/J MGP_AKRJ_G0019338
protein coding gene Chr11:118010124-118044782 (+)
BALB/cJ MGP_BALBcJ_G0019342
protein coding gene Chr11:115007657-115040726 (+)
C3H/HeJ MGP_C3HHeJ_G0019148
protein coding gene Chr11:118361471-118393943 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019792
protein coding gene Chr11:123486699-123528827 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017415
protein coding gene Chr11:111610605-111646484 (+)
CAST/EiJ MGP_CASTEiJ_G0018703
protein coding gene Chr11:119694270-119733452 (+)
CBA/J MGP_CBAJ_G0019120
protein coding gene Chr11:128384587-128418159 (+)
DBA/2J MGP_DBA2J_G0019231
protein coding gene Chr11:114014806-114049448 (+)
FVB/NJ MGP_FVBNJ_G0019223
protein coding gene Chr11:113509152-113549750 (+)
LP/J MGP_LPJ_G0019301
protein coding gene Chr11:120215492-120247897 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019256
protein coding gene Chr11:127494536-127530242 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019830
protein coding gene Chr11:118660328-118696527 (+)
PWK/PhJ MGP_PWKPhJ_G0018467
protein coding gene Chr11:115324749-115360281 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018260
protein coding gene Chr11:118408796-118444397 (+)
WSB/EiJ MGP_WSBEiJ_G0018755
protein coding gene Chr11:118624478-118658886 (+)



Homology
more
  • Human Ortholog
    TMEM94, transmembrane protein 94
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM94, transmembrane protein 94
  • Synonyms
    IDDCDF, KIAA0195
  • Links
    NCBI Gene ID: 9772
    neXtProt AC: NX_Q12767
    UniProt: Q12767

  • Chr Location
    17q25.1; chr17:75441159-75500452 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show lethality by P1, growth retardation, craniofacial and cardiac abnormalities, and abnormal neuronal migration pattern.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71947 NCBI Gene Model | MGI Sequence Detail 33615 C57BL/6J ±  kb
    transcript NM_028014 RefSeq | MGI Sequence Detail 4996 C57BL/6  
    polypeptide Q7TSH8 UniProt | EBI | MGI Sequence Detail 1360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 2
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:269160 Stephen J, et al., Bi-allelic TMEM94 Truncating Variants Are Associated with Neurodevelopmental Delay, Congenital Heart Defects, and Distinct Facial Dysmorphism. Am J Hum Genet. 2018 Dec 6;103(6):948-967

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory