Yaa Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Yaa
accelerated autoimmunity and lymphoproliferation transposition
MGI:99140

45 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
B2m^tm1Unc/B2m^tm1Unc X/Yaa BXSB.129P2(B6)-B2m^tm1Unc/Dcr	increased anti-nuclear antigen antibody level	J:179430
	increased susceptibility to systemic lupus erythematosus	J:179430
	premature death	J:179430
Btk^m1Anu/Btk^m1Anu X/Yaa involves: BXSB/MpJ * C57BL/6JAnu * SB/Le	decreased B cell number	J:104190
Bxs6^BXSB/MpJ/Bxs6^BXSB/MpJ X/Yaa B10.BXSB-(D13Mit3-D13Mit78) Yaa	autoimmune response	J:145049
	enlarged spleen	J:145049
	glomerulonephritis	J:145049
	increased anti-double stranded DNA antibody level	J:145049
	increased anti-single stranded DNA antibody level	J:145049
	increased autoantibody level	J:145049
Cd1d1^tm1Luc/Cd1d1^tm1Luc X/Yaa BXSB.129S6(B6)-Cd1d1^tm1Luc/Dcr	premature death	J:179430
Cd8a^tm1Mak/Cd8a^tm1Mak Il15^tm1Imx/Il15^tm1Imx X/Yaa BXSB.Cg-Cd8a^tm1Mak Il15^tm1Imx/Dcr	abnormal spleen B cell follicle morphology	J:179430
	increased anti-nuclear antigen antibody level	J:179430
	increased IgG1 level	J:179430
	increased IgG2a level	J:179430
	increased IgG2b level	J:179430
	increased monocyte cell number	J:179430
	increased splenocyte number	J:179430
	increased susceptibility to systemic lupus erythematosus	J:179430
	premature death	J:179430
	renal glomerular immunoglobulin deposits	J:179430
Cd8a^tm1Mak/Cd8a^tm1Mak X/Yaa BXSB.129S2(B6)-Cd8a^tm1Mak/4Dcr	increased susceptibility to systemic lupus erythematosus	J:179430
	premature death	J:179430
Dsg4^hage/Dsg4^hage Fas^lpr/Fas^lpr X/Yaa EOD-Dsg4^hage	abnormal effector T cell morphology	J:140028
	abnormal hair follicle morphology	J:140028
	abnormal hair follicle orientation	J:140028
	abnormal mast cell morphology	J:140028
	absent vibrissae	J:140028
	decreased body size	J:140028
	extended life span	J:140028
	sparse hair	J:140028
	thick epidermis	J:140028
Fcgr2b^tm1.2Jsv/Fcgr2b⁺ X/Yaa involves: C57BL/6 * FVB/N * SB/Le	abnormal kidney morphology	J:179175
	enlarged spleen	J:179175
	increased anti-chromatin antibody level	J:179175
	increased anti-double stranded DNA antibody level	J:179175
	increased monocyte cell number	J:179175
	increased susceptibility to systemic lupus erythematosus	J:179175
	premature death	J:179175
Fcgr2b^tm1Ttk/Fcgr2b⁺ X/Yaa involves: 129S4/SvJae * C57BL/6 * SB/Le	increased monocyte cell number	J:129409
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Tlr7^tm1Flv/Y X/Yaa B6.Cg-Fcgr2b^tm1Ttk Tlr7^tm1Flv Yaa	abnormal kidney morphology	J:127600
	abnormal splenocyte physiology	J:127600
	autoimmune response	J:127600
	enlarged spleen	J:127600
	increased anti-nuclear antigen antibody level	J:127600
	increased susceptibility to systemic lupus erythematosus	J:127600
	premature death	J:127600
Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk X/Yaa B6.Cg-Fcgr2b^tm1Ttk Yaa	abnormal kidney morphology	J:127600
	autoimmune response	J:127600
	enlarged spleen	J:127600
	increased anti-nuclear antigen antibody level	J:127600
	increased susceptibility to systemic lupus erythematosus	J:127600
	premature death	J:127600
Fcgrt^tm1Dcr/Fcgrt^tm1Dcr X/Yaa BXSB.129X1-Fcgrt^tm1Dcr/Dcr	premature death	J:179430
H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe X/Yaa BXSB.129P2(B6)-H2-K1^b-tm1Bpe H2-D1^b-tm1Bpe/Dcr	increased susceptibility to systemic lupus erythematosus	J:179430
	premature death	J:179430
Ighm^tm1Cgn/Ighm^tm1Cgn X/Yaa BXSB.129S2(B6)-Ighm^tm1Cgn/Dcr	decreased susceptibility to systemic lupus erythematosus	J:206236
Il15^tm1Imx/Il15^tm1Imx X/Yaa BXSB.B6-Il15^tm1Imx/Dcr	increased susceptibility to systemic lupus erythematosus	J:179430
Il15^tm1Imx/Il15^tm1Imx X/Yaa BXSB.B6-Il15^tm1Imx/Dcr	premature death	J:179430
Il21r^tm1Wjl/Il21r^tm1Wjl X/Yaa BXSB.129(Cg)-Il21r^tm1Wjl/Dcr	decreased susceptibility to systemic lupus erythematosus	J:144484
	normal mortality/aging	J:144484, J:179430
ll/ll X/Yaa BXSB/MpJScr-ll	abnormal monocyte morphology	J:10973
	normal cardiovascular system phenotype	J:10973
	decreased anti-nuclear antigen antibody level	J:10973
	decreased CD4-positive, alpha-beta T cell number	J:10973
	decreased IgG level	J:10973
	decreased susceptibility to autoimmune disorder	J:10973
	extended life span	J:10973
	increased lymphoma incidence	J:10973
	increased T cell derived lymphoma incidence	J:10973
	normal renal/urinary system phenotype	J:10973
Nba10^NZB/Nba10^NZB Tlr7^tm1Aki/Y X/Yaa B6.Cg-Nba10^NZB Tlr7^tm1Aki Yaa	abnormal immune serum protein physiology	J:137656
	glomerulonephritis	J:137656
	increased anti-chromatin antibody level	J:137656
	increased monocyte cell number	J:137656
Nba10^NZB/Nba10^NZB X/Yaa C57BL/6-Nba2 Yaa	abnormal immune serum protein physiology	J:137656
	glomerulonephritis	J:95829, J:137656
	increased anti-chromatin antibody level	J:137656
	increased anti-nuclear antigen antibody level	J:95829
	increased autoantibody level	J:137656
	increased monocyte cell number	J:129409, J:137656
	increased susceptibility to autoimmune disorder	J:95829
	increased susceptibility to type III hypersensitivity reaction	J:95829
Prf1^tm1Sdz/Prf1^tm1Sdz X/Yaa BXSB.B6-Prf1^tm1Sdz/Dcr	autoimmune response	J:179430
Prf1^tm1Sdz/Prf1^tm1Sdz X/Yaa BXSB.B6-Prf1^tm1Sdz/Dcr	premature death	J:179430
Tap1^tm1Arp/Tap1^tm1Arp X/Yaa BXSB.129S2(B6)-Tap1^tm1Arp/Dcr	increased susceptibility to systemic lupus erythematosus	J:179430
Tcra^tm1Mjo/Tcra^tm1Mjo X/Yaa BXSB.129P2(Cg)-Tcra^tm1Mjo/Theo	normal immune system phenotype	J:120153
Tlr7^tm1Flv/Y X/Yaa B6.Cg-Tlr7^tm1Flv Yaa	normal hematopoietic system phenotype	J:127600

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23