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Spontaneous Allele Detail
Symbol: Dsg4hage
Name: desmoglein 4; hage
MGI ID: MGI:3766998
Gene: Dsg4  Location: Chr18:20569232-20604878 bp, + strand  Genetic Position: Chr18, 11.35 cM
Alliance: Dsg4hage page
Strain of Origin:  EOD
Allele Type:    Spontaneous
Mutation:    Insertion
Mutation detailsThis mutation was induced by the insertion of an early transposon II- into intron 8 of the gene locus. The 5,543-bp ETn II- was integrated into intron 8, 203 bp away from the initial nucleotide of intron 8; it was flanked by a duplicated 6-bp repeat (ACTAGG) that originated from genomic sequence. 183-bp of this insertion acted as a pseudo exon by being transcribed in-frame, which disrupted the normal coding sequence for the extracellular cadherin repeat 3 (EC3) domain of the gene product. (J:140028)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dsg4 Mutation:  66 strains or lines available
Original:  J:140028 Zhang MC, et al., Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice. Immunogenetics. 2008 Oct;60(10):599-607
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory