83 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh Xpatm1Hvs/Xpatm1Hvs involves: 129P2/OlaHsd * C57BL/6	abnormal adipose tissue distribution	J:76608
	abnormal cell death	J:76608
	abnormal gait	J:76608
	cachexia	J:76608
	dilated hair follicle	J:76608
	hyperkeratosis	J:76608
	increased cellular sensitivity to oxidative stress	J:76608
	increased cellular sensitivity to ultraviolet irradiation	J:76608
	increased cellular sensitivity to X-ray irradiation	J:76608
	kyphosis	J:76608
	neonatal lethality, incomplete penetrance	J:76608
	osteoporosis	J:76608
	postnatal growth retardation	J:76608
	postnatal lethality, complete penetrance	J:76608
	premature aging	J:76608
Ercc2tm3Jhjh/Ercc2tm3Jhjh Xpatm1Hvs/Xpatm1Hvs involves: 129P2/OlaHsd * C57BL/6 * FVB	ataxia	J:112689
	impaired balance	J:112689
	postnatal growth retardation	J:112689
	postnatal lethality, complete penetrance	J:112689
	Purkinje cell degeneration	J:112689
	tremors	J:112689
Ercc3tm2Jhjh/Ercc3tm2Jhjh Xpatm1Hvs/Xpatm1Hvs involves: 129P2/OlaHsd * C57BL/6	abnormal cranium morphology	J:145759
	abnormal gait	J:145759
	ataxia	J:145759
	cachexia	J:145759
	decreased body weight	J:145759
	hyperactivity	J:145759
	impaired balance	J:145759
	impaired limb coordination	J:145759
	increased cellular sensitivity to gamma-irradiation	J:145759
	increased cellular sensitivity to oxidative stress	J:145759
	increased cellular sensitivity to ultraviolet irradiation	J:145759
	kyphosis	J:145759
	muscle hypertonia	J:145759
	premature aging	J:145759
	premature death	J:145759
	slow postnatal weight gain	J:145759
	testicular atrophy	J:145759
	tremors	J:145759
Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Gvh/Xpatm1Hvs Tg(CAG-cre)13Miya/0 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	abnormal gait	J:179808
	cachexia	J:179808
	postnatal growth retardation	J:179808
	postnatal lethality, complete penetrance	J:179808
Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Gvh/Xpatm1Hvs Tg(Camk2a-cre)1Szi/0 involves: 129P2/OlaHsd * C57BL/6J * CBA	abnormal cerebral cortex morphology	J:179808
	abnormal dorsal striatum morphology	J:179808
	abnormal neocortex morphology	J:179808
	abnormal telencephalon morphology	J:179808
	astrocytosis	J:179808
	decreased body size	J:179808
	decreased body weight	J:179808
	dilated lateral ventricle	J:179808
	hippocampus atrophy	J:179808
	impaired coordination	J:179808
	increased thigmotaxis	J:179808
	microgliosis	J:179808
	neuron degeneration	J:179808
	premature death	J:179808
	seizures	J:179808
	thin cerebral cortex	J:179808
Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Gvh/Xpatm1Hvs Tg(Pcp2-cre)2Mpin/0 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J	astrocytosis	J:179808
	axon degeneration	J:179808
	microgliosis	J:179808
	Purkinje cell degeneration	J:179808
Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Hvs/Xpatm1Hvs B6.129P2-Xpatm1Hvs Ercc6tm1Gvh	abnormal abdominal fat pad morphology	J:122013
	abnormal epiphyseal plate morphology	J:122013
	abnormal gait	J:122013
	abnormal limb posture	J:122013
	abnormal Purkinje cell morphology	J:122013
	abnormal retina inner nuclear layer morphology	J:122013
	abnormal retina morphology	J:122013
	abnormal retina outer nuclear layer morphology	J:122013
	ataxia	J:122013
	dystonia	J:122013
	hepatic steatosis	J:122013
	hypoglycemia	J:122013
	increased cellular sensitivity to gamma-irradiation	J:122013
	increased liver glycogen level	J:122013
	kyphosis	J:122013
	lipodystrophy	J:122013
	long limbs	J:122013
	postnatal growth retardation	J:122013
	premature aging	J:122013
	retina degeneration	J:122013
	short stride length	J:122013
	tremors	J:122013
Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Hvs/Xpatm1Hvs involves: 129P2/OlaHsd * C57BL/6J	abnormal base-excision repair	J:122013
	cachexia	J:122013
	disproportionate dwarf	J:122013
	increased cellular sensitivity to ultraviolet irradiation	J:122013
	perinatal lethality, incomplete penetrance	J:122013
	postnatal growth retardation	J:122013
	postnatal lethality, complete penetrance	J:122013
Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Tnka/Xpatm1Tnka involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal cerebellar cortex morphology	J:72574
	abnormal cerebellar Purkinje cell layer	J:72574
	abnormal cerebellum development	J:72574
	abnormal gait	J:72574
	abnormal Purkinje cell dendrite morphology	J:72574
	ataxia	J:72574
	decreased brain weight	J:72574
	decreased cerebellar granule cell precursor proliferation	J:72574
	impaired balance	J:72574
	limb grasping	J:72574
	postnatal lethality, complete penetrance	J:72574
	reduced cerebellar foliation	J:72574
	slow postnatal weight gain	J:72574
	small cerebellum	J:72574
	thin cerebellar granule layer	J:72574
	thin cerebellar molecular layer	J:72574
	tremors	J:72574
Hrhr/Hrhr Msh2tm1Htr/Msh2tm1Htr Xpatm1Tnka/Xpatm1Tnka involves: 129P2/OlaHsd * C57BL/6 * CBA	increased incidence of tumors by UV-induction	J:79734
	increased lymphoma incidence	J:79734
	increased mortality induced by ionizing radiation	J:79734
	increased skin papilloma incidence	J:79734
	increased skin squamous cell carcinoma incidence	J:79734
	increased skin tumor incidence	J:79734
	premature death	J:79734
Hrhr/Hrhr Xpatm1Tnka/Xpatm1Tnka involves: C57BL/6 * CBA	increased skin tumor incidence	J:79734
Trp53tm1Tyj/Trp53+ Xpatm1Hvs/Xpatm1Hvs involves: 129P2/OlaHsd * 129S2/SvPas	increased incidence of tumors by chemical induction	J:170769
	increased urinary system tumor incidence	J:170769
Xpatm1Tnka/Xpatm1Tnka Tg(KRT14-Kitl)1Takk/? involves: C57BL/6 * CBA * SJL	abnormal coat/hair pigmentation	J:100608
	abnormal epidermal pigmentation	J:100608
	increased metastatic potential	J:100608
	increased skin tumor incidence	J:100608