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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tcf3
transcription factor 3
MGI:98510
54 phenotypes from 19 alleles in 24 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Cd19tm1(cre)Cgn/\Cd19+
\Tcf3tm1Mbu/\Tcf3tm1.2Mbu
involves: 129P2/OlaHsd * C57BL/6 * SJL 		decreased B cell number J:137719
decreased immature B cell number J:137719
decreased mature B cell number J:137719
decreased pre-B cell number J:137719
decreased pro-B cell number J:137719
decreased transitional stage B cell number J:137719
\Tcf3tm1(TCF3/HLF)Homy/\Tcf3+
involves: 129P2/OlaHsd * C57BL/6 		normal hematopoietic system phenotype J:160392
normal mortality/aging J:160392
\Tcf3tm1(TCF3/HLF)Homy/\Tcf3+
\Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal B cell differentiation J:160392
abnormal thrombosis J:160392
normal hematopoietic system phenotype J:160392
increased B cell number J:160392
increased incidence of induced tumors J:160392
increased susceptibility to induced morbidity/mortality J:160392
normal mortality/aging J:160392
\Tcf3tm1.1Mbu/\Tcf3+
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell differentiation J:137719
\Tcf3tm1Cmu/\Tcf3+
either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N) 		decreased B cell number J:67011
\Tcf3tm1Cmu/\Tcf3tm1Cmu
either: 129P2/OlaHsd-Tcf3tm1Cmu or (involves: 129P2/OlaHsd * FVB/N) 		abnormal blood cell morphology/development J:67011
abnormal immunoglobulin heavy chain V(D)J recombination J:67011
abnormal immunoglobulin V(D)J recombination J:67011
abnormal T cell subpopulation ratio J:67011
decreased B cell number J:67011
decreased lymphocyte cell number J:67011
postnatal lethality, incomplete penetrance J:67011
\Tcf3tm1Mbu/\Tcf3tm1.2Mbu
\Tg(Aicda-cre)9Mbu/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL 		abnormal germinal center B cell morphology J:137719
decreased B cell number J:137719
decreased germinal center B cell number J:137719
normal immune system phenotype J:137719
\Tcf3tm1Mbu/\Tcf3tm1.2Mbu
\Tg(Fcer2a-cre)5Mbu/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL 		abnormal germinal center B cell morphology J:137719
decreased B cell number J:137719
decreased germinal center B cell number J:137719
normal immune system phenotype J:137719
increased marginal zone B cell number J:137719
\Tcf3tm1Mbu/\Tcf3tm1Mbu
\Commd10Tg(Vav1-icre)A2Kio/\Commd10+
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca 		decreased pro-B cell number J:137719
\Tcf3tm1Mbu/\Tcf3tm1Mbu
\Tg(Ikzf1-Tcfe2a,-GFP)1Mbu/0
\Commd10Tg(Vav1-icre)A2Kio/\Commd10+
involves: 129P2/OlaHsd * C57BL * CBA 		normal immune system phenotype J:137719
\Tcf3tm1Wein/\Tcf3+
either: (involves: 129/Sv * 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J) 		decreased B cell number J:22134
\Tcf3tm1Wein/\Tcf3+
involves: 129S4/SvJaeSor 		abnormal B cell number J:91042
decreased pre-B cell number J:91042
\Tcf3tm1Wein/\Tcf3tm1Wein
either: (involves: 129 * 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J) 		abnormal B cell number J:22134
abnormal lymphocyte cell number J:22134
postnatal growth retardation J:22134
postnatal lethality, incomplete penetrance J:22134
spleen atrophy J:22134
\Tcf3tm1Wein/\Tcf3tm1Wein
involves: 129S4/SvJaeSor 		female infertility J:47671
\Tcf3tm1Wein/\Tcf3tm1Wein
involves: 129S4/SvJaeSor * C57BL/6 		enlarged thymus J:44278
increased T cell derived lymphoma incidence J:44278
neonatal lethality, incomplete penetrance J:44278
premature death J:44278
\Tcf3tm1Wein/\Tcf3tm3Zhu
involves: 129/Sv * 129S4/SvJaeSor * C57BL/6 		decreased pro-B cell number J:47671
postnatal lethality, incomplete penetrance J:47671
\Tcf3tm1Xhsu/\Tcf3tm1Xhsu
B6.129X1-Tcf3tm1Xhsu 		normal immune system phenotype J:132669
increased B cell number J:132669
\Tcf3tm1Zhu/\Tcf3tm1Zhu
involves: 129 		abnormal hematopoietic stem cell morphology J:47671
decreased B cell number J:47671
female infertility J:47671
normal nervous system phenotype J:125313
premature death J:47671
\Tcf3tm1Zhu/\Tcf3tm1Zhu
involves: 129 * C57BL/6J 		decreased double-positive T cell number J:136143
increased double-negative T cell number J:136143
increased single-positive T cell number J:136143
thymus hypoplasia J:136143
\Tcf3tm1Zhu/\Tcf3tm2Zhu
involves: 129 * C57BL/6 		decreased B cell number J:47671
\Tcf3tm2Cmu/\Tcf3tm2Cmu
involves: 129P2/OlaHsd 		abnormal cell death J:118827
abnormal lymphopoiesis J:118827
absent pre-B cells J:118827
absent pro-B cells J:118827
decreased dendritic cell number J:118827
decreased NK cell number J:118827
increased cell proliferation J:118827
\Tcf3tm2Wein/\Tcf3tm2Wein
Not Specified 		abnormal hematopoietic system morphology/development J:47671
abnormal immune system morphology J:47671
female infertility J:47671
increased T cell derived lymphoma incidence J:47671
postnatal growth retardation J:47671
postnatal lethality J:47671
premature death J:47671
\Tcf3tm2Zhu/\Tcf3tm2Zhu
involves: 129 * C57BL/6 		abnormal hematopoietic stem cell morphology J:47671
decreased pre-B cell number J:47671
decreased pro-B cell number J:47671
normal mortality/aging J:47671
normal reproductive system phenotype J:47671
\Tcf3tm2Zhu/\Tcf3tm2Zhu
involves: 129/Sv * C57BL/6 		decreased body size J:154788
premature death J:154788
\Tcf3tm3.1Cmu/\Tcf3tm3.1Cmu
involves: 129S/SvEv * FVB/N 		abnormal B cell differentiation J:153423
abnormal immunoglobulin light chain V-J recombination J:153423
decreased pre-B cell number J:153423
\Tcf3tm3Zhu/\Tcf3tm3Zhu
involves: 129/Sv * C57BL/6 		decreased B cell number J:47671
normal immune system phenotype J:47671
\Tcf3tm4.1Cmu/\Tcf3tm4.1Cmu
involves: 129S/SvEv * FVB/N 		abnormal immunoglobulin light chain V-J recombination J:153423
absent B cells J:153423
arrested B cell differentiation J:153423
decreased pro-B cell number J:153423
\Tcf3tm4Zhu/\Tcf3tm4Zhu
\Tg(Lck-cre)#Zhu/0
involves: 129S4/SvJae * C57BL/6 * SJL 		normal immune system phenotype J:75746
\Tcf3tm4Zhu/\Tcf3tm4Zhu
\Tg(NPHS2-cre)295Lbh/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL 		no abnormal phenotype detected J:122505
\Tcf3tm5.1Cmu/\Tcf3tm5.1Cmu
involves: 129S/SvEv * C57BL/6 		normal immune system phenotype J:183781
no abnormal phenotype detected J:183781
\Tcf3tm5Zhu/\Tcf3tm5Zhu
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:75746
\Tcf3tm6(Esr1*)Zhu/\Tcf3tm6(Esr1*)Zhu
involves: 129/Sv * C57BL/6 		abnormal immunoglobulin heavy chain V(D)J recombination J:154788
arrested B cell differentiation J:154788
postnatal growth retardation J:154788
premature death J:154788
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory