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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pdgfra
platelet derived growth factor receptor, alpha polypeptide
MGI:97530
151 phenotypes from 13 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Pdgfratm12Sor/Pdgfra+
involves: 129 * C57BL/6 		abnormal cecum morphology J:146617
abnormal small intestine morphology J:146617
cardiac fibrosis J:146617
glomerulosclerosis J:146617
increased sarcoma incidence J:146617
intestinal fibrosis J:146617
intestine polyps J:146617
premature death J:146617
pulmonary fibrosis J:146617
renal glomerulus fibrosis J:146617
renal glomerulus hypertrophy J:146617
renal interstitial fibrosis J:146617
skeletal muscle interstitial fibrosis J:146617
tight skin J:146617
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Pdgfratm13Sor/Pdgfra+
involves: 129S4/SvJaeSor * C57BL/6 		cardiac fibrosis J:146617
glomerulosclerosis J:146617
intestinal fibrosis J:146617
intestine polyps J:146617
renal glomerulus hypertrophy J:146617
skeletal muscle interstitial fibrosis J:146617
tight skin J:146617
Pdgfraem1(IMPC)Ccpcz/Pdgfra+
C57BL/6NCrl-Pdgfraem1(IMPC)Ccpcz/Ccpcz 		abnormal behavior J:211773
abnormal kidney morphology J:211773
abnormal lymph node morphology J:211773
abnormal skin morphology J:211773
abnormal testis morphology J:211773
abnormal thymus morphology J:211773
decreased CD8-positive, naive alpha-beta T cell number J:211773
decreased circulating HDL cholesterol level J:211773
enlarged kidney J:211773
enlarged lymph nodes J:211773
enlarged thymus J:211773
increased airway resistance J:211773
increased CD4-positive NK T cell number J:211773
increased kidney weight J:211773
increased memory-marker CD4-positive NK T cell number J:211773
increased NK T cell number J:211773
small testis J:211773
Pdgfraem1(IMPC)Ccpcz/Pdgfraem1(IMPC)Ccpcz
C57BL/6NCrl-Pdgfraem1(IMPC)Ccpcz/Ccpcz 		preweaning lethality, complete penetrance J:211773
Pdgfratm1.1(cre/Esr1*)Nshk/Pdgfratm1.1(cre/Esr1*)Nshk
involves: C57BL/6NCrlj * CBA/JNCrlj 		normal hematopoietic system phenotype J:193389
Pdgfratm1.1(EGFP/cre/ERT2)Hyma/Pdgfra+
involves: C57BL/6 * CBA/JNCrlj 		normal cellular phenotype J:221424
normal growth/size/body region phenotype J:221424
Pdgfratm1Sor/Pdgfra+
either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J) 		normal pigmentation phenotype J:41814
Pdgfratm1Sor/Pdgfratm1Sor
either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J) 		abnormal cervical vertebrae morphology J:41814
abnormal cranial neural crest cell morphology J:41814
abnormal frontal bone morphology J:41814
abnormal myotome development J:41814
abnormal myotome morphology J:41814
abnormal nasal bone morphology J:41814
abnormal neural tube morphology J:41814
abnormal parietal bone morphology J:41814
abnormal scapula morphology J:41814
abnormal spine curvature J:41814
abnormal sternum morphology J:41814
abnormal thoracic vertebrae morphology J:41814
abnormal vitelline vasculature morphology J:41814
absent roof plate J:41814
absent zygomatic bone J:41814
acromion hypoplasia J:41814
decreased embryo size J:41814
edema J:41814
embryonic growth retardation J:41814
failure of somite differentiation J:41814
fetal bleb J:41814
hemorrhage J:41814
herniated abdominal wall J:41814
impaired ossification of basisphenoid bone J:41814
incomplete embryo turning J:41814
incomplete rostral neuropore closure J:41814
increased apoptosis J:41814
lethality throughout fetal growth and development, incomplete penetrance J:41814
midline facial cleft J:41814
pericardial edema J:41814
normal pigmentation phenotype J:41814
rib bifurcation J:41814
rib fusion J:41814
skin edema J:41814
spina bifida J:41814
thin epidermis J:41814
wavy neural tube J:41814
Pdgfratm1Sor/Pdgfratm1Sor
involves: 129S4/SvJaeSor 		short ureter J:146617
Pdgfratm2Sor/Pdgfra+
either: 129S4/SvJaeSor-Pdgfratm2Sor or (involves: 129S4/SvJaeSor * C57BL/6J) 		normal pigmentation phenotype J:41814
Pdgfratm2Sor/Pdgfratm2Sor
either: 129S4/SvJaeSor-Pdgfratm2Sor or (involves: 129S4/SvJaeSor * C57BL/6J) 		abnormal cervical vertebrae morphology J:41814
abnormal cranial neural crest cell morphology J:41814
abnormal frontal bone morphology J:41814
abnormal myotome development J:41814
abnormal myotome morphology J:41814
abnormal nasal bone morphology J:41814
abnormal neural tube morphology J:41814
abnormal parietal bone morphology J:41814
abnormal scapula morphology J:41814
abnormal spine curvature J:41814
abnormal sternum morphology J:41814
abnormal thoracic vertebrae morphology J:41814
abnormal vitelline vasculature morphology J:41814
absent roof plate J:41814
absent zygomatic bone J:41814
acromion hypoplasia J:41814
decreased embryo size J:41814
edema J:41814
embryonic growth retardation J:41814
failure of somite differentiation J:41814
fetal bleb J:41814
hemorrhage J:41814
herniated abdominal wall J:41814
impaired ossification of basisphenoid bone J:41814
incomplete embryo turning J:41814
incomplete rostral neuropore closure J:41814
increased apoptosis J:41814
lethality throughout fetal growth and development, incomplete penetrance J:41814
midline facial cleft J:41814
pericardial edema J:41814
normal pigmentation phenotype J:41814
rib bifurcation J:41814
rib fusion J:41814
skin edema J:41814
spina bifida J:41814
thin epidermis J:41814
wavy neural tube J:41814
Pdgfratm2Sor/Pdgfratm2Sor
involves: 129S4/SvJaeSor 		abnormal dorsal mesocardium morphology J:157946
abnormal heart atrium morphology J:157946
anomalous pulmonary venous connection J:157946
dual inferior vena cava J:157946
embryonic lethality during organogenesis, incomplete penetrance J:157946
pulmonary hypoplasia J:157946
pulmonary vein hypoplasia J:157946
total anomalous pulmonary venous connection J:157946
Pdgfratm2Sor/Pdgfratm2Sor
involves: 129S4/SvJaeSor * C57BL/6 		abnormal diaphragm development J:160875
diaphragmatic hernia J:160875
embryonic lethality during organogenesis, incomplete penetrance J:160875
pulmonary hypoplasia J:160875
ventricular septal defect J:160875
Pdgfratm8Sor/Pdgfratm8Sor
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129X1/SvJ 		abnormal dorsal mesocardium morphology J:157946
dual inferior vena cava J:157946
total anomalous pulmonary venous connection J:157946
Pdgfratm8Sor/Pdgfratm8Sor
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6 * CBA 		delayed heart development J:122584
persistent truncus arteriosus J:122584
retroesophageal right subclavian artery J:122584
ventricular septal defect J:122584
Pdgfratm8Sor/Pdgfratm8Sor
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Not Specified 		abnormal frontal bone morphology J:81153
abnormal frontonasal prominence morphology J:81153
abnormal nasal bone morphology J:81153
abnormal nasal capsule morphology J:81153
abnormal vasculogenesis J:81153
hemorrhage J:81153
midline facial cleft J:81153
perimembraneous ventricular septal defect J:81153
persistent truncus arteriosus J:81153
postnatal lethality J:81153
short snout J:81153
small thymus J:81153
Pdgfratm8Sor/Pdgfratm8Sor
Hoxa3tm1(cre)Moon/Hoxa3+
Not Specified 		abnormal dorsal mesocardium morphology J:157946
dual inferior vena cava J:157946
total anomalous pulmonary venous connection J:157946
Pdgfratm8Sor/Pdgfratm8Sor
Tg(Col2a1-cre)1Rsjo/0
involves: FVB/N 		abnormal skeleton development J:174096
decreased body weight J:174096
decreased cranium height J:174096
Pdgfratm8Sor/Pdgfratm8Sor
Tg(Leftb-cre)1Hmd/0
Not Specified 		abnormal dorsal mesocardium morphology J:157946
dual inferior vena cava J:157946
total anomalous pulmonary venous connection J:157946
Pdgfratm8Sor/Pdgfratm8Sor
Tg(Nr5a1-cre)2Klp/0
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) 		abnormal ovarian follicle morphology J:142042
abnormal spermatocyte morphology J:142042
abnormal testis cord formation J:142042
abnormal testis morphology J:142042
abnormal testosterone level J:142042
anovulation J:142042
decreased circulating estradiol level J:142042
decreased Leydig cell number J:142042
decreased theca cell number J:142042
delayed fertility J:142042
oligozoospermia J:142042
normal reproductive system phenotype J:142042
small ovary J:142042
small testis J:142042
uterus hypoplasia J:142042
Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfra+
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) 		abnormal pubis morphology J:83560
abnormal trophoblast layer morphology J:83560
cleft palate J:83560
ectopic cranial bone J:83560
enlarged placenta J:83560
open neural tube J:83560
polydactyly J:83560
rib fusion J:83560
spina bifida J:83560
Pdgfratm9(Pdgfra/Fgfr1)Sor/Pdgfratm11(EGFP)Sor
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) 		embryonic lethality during organogenesis, complete penetrance J:83560
failure of initiation of embryo turning J:83560
failure of somite differentiation J:83560
Pdgfratm10(Pdgfra/tor)Sor/Pdgfratm10(Pdgfra/tor)Sor
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) 		abnormal heart septum morphology J:83560
abnormal rib joint morphology J:83560
absent sternum J:83560
normal cardiovascular system phenotype J:83560
cleft palate J:83560
hydrops fetalis J:83560
lethality throughout fetal growth and development, incomplete penetrance J:83560
midline facial cleft J:83560
open neural tube J:83560
spina bifida J:83560
Pdgfratm10(Pdgfra/tor)Sor/Pdgfratm11(EGFP)Sor
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) 		abnormal placenta development J:83560
prenatal lethality, complete penetrance J:83560
Pdgfratm11(EGFP)Sor/Pdgfratm11(EGFP)Sor
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) 		abnormal placenta development J:83560
abnormal placenta vasculature J:83560
prenatal lethality J:83560
Pdgfratm12.1Sor/Pdgfra+
involves: 129 * C57BL/6 		abnormal immune system organ morphology J:146617
abnormal kidney pelvis morphology J:146617
abnormal lung development J:146617
abnormal mesenchyme morphology J:146617
abnormal rib morphology J:146617
abnormal sternum morphology J:146617
abnormal stomach morphology J:146617
abnormal ureter development J:146617
abnormal ureter morphology J:146617
abnormal ureter smooth muscle morphology J:146617
edema J:146617
esophagus hyperplasia J:146617
increased cell proliferation J:146617
increased embryo size J:146617
increased fetal size J:146617
increased fibroblast chemotaxis J:146617
increased fibroblast proliferation J:146617
increased mesenchymal cell proliferation involved in lung development J:146617
postnatal lethality, complete penetrance J:146617
pulmonary hyperplasia J:146617
ureter obstruction J:146617
wide sternum J:146617
Pdgfratm13.1Sor/Pdgfra+
involves: 129 * C57BL/6 		abnormal kidney pelvis morphology J:146617
abnormal stomach morphology J:146617
abnormal ureter morphology J:146617
abnormal ureter smooth muscle morphology J:146617
dilated ureter J:146617
esophagus hyperplasia J:146617
hydronephrosis J:146617
increased fibroblast proliferation J:146617
postnatal lethality, incomplete penetrance J:146617
ureter obstruction J:146617
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory