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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
MGI:97384
143 phenotypes from 20 alleles in 27 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ntrk2tm1.1Lfr/Ntrk2+
involves: 129X1/SvJ 		abnormal peripheral nervous system regeneration J:116954
Ntrk2tm1.1Tes/Ntrk2+
B6.129S1-Ntrk2tm1.1Tes 		increased thigmotaxis J:144845
Ntrk2tm1.1Tes/Ntrk2tm1.1Tes
B6.129S1-Ntrk2tm1.1Tes 		abnormal amygdala morphology J:144845
abnormal dendrite morphology J:144845
increased thigmotaxis J:144845
Ntrk2tm1.1Tes/Ntrk2tm1.1Tes
involves: 129S1/Sv 		abnormal mammary gland sensory innervation pattern J:192549
Ntrk2tm1b(EUCOMM)Wtsi/Ntrk2+
C57BL/6N-Ntrk2tm1b(EUCOMM)Wtsi/H 		abnormal rib morphology J:211773
decreased prepulse inhibition J:211773
increased circulating HDL cholesterol level J:211773
increased lean body mass J:211773
Ntrk2tm1b(EUCOMM)Wtsi/Ntrk2tm1b(EUCOMM)Wtsi
C57BL/6N-Ntrk2tm1b(EUCOMM)Wtsi/H 		preweaning lethality, incomplete penetrance J:211773
Ntrk2tm1Bbd/Ntrk2tm1Bbd
involves: 129S2/SvPas 		abnormal barrel cortex morphology J:103935
abnormal cerebellum development J:49472
abnormal Purkinje cell dendrite morphology J:49472
abnormal sensory neuron innervation pattern J:103935, J:104489
abnormal somatic nervous system morphology J:104489
postnatal lethality, complete penetrance J:104489
small cochlear ganglion J:104489
small geniculate ganglion J:104489
small L4 dorsal root ganglion J:104489
small nodose ganglion J:49472, J:104489
small petrosal ganglion J:104489
small trigeminal ganglion J:104489
small vestibular ganglion J:49472, J:104489
Ntrk2tm1Bbd/Ntrk2tm1Bbd
involves: 129S2/SvPas * C57BL/6 		abnormal cochlear ganglion morphology J:29245
abnormal cochlear OHC afferent innervation pattern J:29245
abnormal crista ampullaris neuroepithelium morphology J:29245
abnormal inner ear vestibular sensory neuron innervation pattern J:29245
abnormal sensory neuron innervation pattern J:29245
abnormal utricular macula morphology J:29245
abnormal vestibular ganglion morphology J:29245
abnormal vestibular nerve morphology J:29245
abnormal vibrissae reflex J:56847
absent suckling reflex J:56847
decreased motor neuron number J:56847
neonatal lethality, incomplete penetrance J:56847
no swallowing reflex J:56847
small cochlear ganglion J:29245
small dorsal root ganglion J:56847
small facial motor nucleus J:56847
small trigeminal ganglion J:56847
small vestibular ganglion J:29245
Ntrk2tm1Bbd/Ntrk2tm1Kln
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ 		abnormal cochlear OHC afferent innervation pattern J:84871
abnormal cochlear sensory epithelium morphology J:84871
abnormal inner ear vestibular sensory neuron innervation pattern J:84871
abnormal type I vestibular cell J:84871
increased or absent distortion product otoacoustic emission threshold J:84871
normal mortality/aging J:84871
Ntrk2tm1Bbd/Ntrk2tm2Kln
Tg(Camk2a-cre)159Kln/0
involves: 129S2/SvPas * CBA/J 		abnormal avoidance learning behavior J:58229
abnormal contextual conditioning behavior J:58229
abnormal learning/memory/conditioning J:58229
abnormal myelination J:58229
abnormal spatial learning J:58229
increased thigmotaxis J:58229
reduced long-term potentiation J:58229
Ntrk2tm1Bxu/Ntrk2tm1Bxu
involves: 129 * C57BL/6 		abnormal dopaminergic neuron morphology J:170724
abnormal innervation J:170724
decreased dopaminergic neuron number J:170724
gliosis J:170724
increased susceptibility to dopaminergic neuron neurotoxicity J:170724
normal mortality/aging J:170724
neurodegeneration J:170724
Ntrk2tm1Ddg/Ntrk2tm1Ddg
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:99603
Ntrk2tm1Ddg/Ntrk2tm1Ddg
involves: 129S6/SvEvTac 		abnormal mammary gland sensory innervation pattern J:192549
Ntrk2tm1Jom/Ntrk2+
Tg(Syn1-cre)671Jxm/0
involves: 129/Sv * C57BL/6 * ICR 		decreased kindling response J:91467
Ntrk2tm1Jom/Ntrk2tm1Jom
Tg(GFAP-cre)25Mes/0
involves: FVB/N 		normal nervous system phenotype J:103935
Ntrk2tm1Jom/Ntrk2tm1Jom
Tg(Syn1-cre)671Jxm/0
involves: 129/Sv * C57BL/6 * ICR 		decreased kindling response J:91467
Ntrk2tm1Kln/Ntrk2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal endocrine/exocrine gland phenotype J:210229
normal growth/size/body region phenotype J:210229
Ntrk2tm1Kln/Ntrk2tm1Kln
involves: 129S1/Sv * 129X1/SvJ 		abnormal inner ear vestibular sensory neuron innervation pattern J:75365, J:84871
abnormal inner ear vestibule morphology J:84871
abnormal sensory neuron innervation pattern J:75365
abnormal somatic sensory system morphology J:49472, J:75365
abnormal synapse morphology J:75365
abnormal vestibular nerve morphology J:75365
abnormal vestibulocochlear nerve morphology J:75365
absent hair-down neurons J:49472
decreased sensory neuron number J:75365
hyperactivity J:49472
small nodose ganglion J:49472
small vestibular ganglion J:49472
Ntrk2tm1Lfp/Ntrk2tm1Lfp
involves: 129 		abnormal barrel cortex morphology J:103935
abnormal sensory neuron innervation pattern J:103935
Ntrk2tm1Lfp/Ntrk2tm1Lfp
involves: 129 * C57 		abnormal sensory neuron innervation pattern J:104489
abnormal somatic nervous system morphology J:104489
postnatal lethality, complete penetrance J:104489
small cochlear ganglion J:104489
small geniculate ganglion J:104489
small nodose ganglion J:104489
small petrosal ganglion J:104489
small trigeminal ganglion J:104489
small vestibular ganglion J:104489
Ntrk2tm1Lfr/Ntrk2+
involves: 129X1/SvJ 		abnormal retina ganglion cell morphology J:122929
Ntrk2tm1Lfr/Ntrk2tm1Lfr
involves: 129X1/SvJ 		abnormal retina ganglion cell morphology J:119332, J:122929
decreased retina ganglion cell number J:119332
Ntrk2tm1Lfr/Ntrk2tm1Lfr
Tg(Camk2a-cre)1Lfr/0
involves: 129X1/SvJ * C57BL/6 * DBA 		abnormal dendrite morphology J:77452
abnormal neuron morphology J:77452
abnormal somatosensory cortex morphology J:77452
abnormal visual cortex morphology J:77452
decreased neuron number J:77452
Ntrk2tm1Mini/Ntrk2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal liver morphology J:210229
adrenal cortical hyperplasia J:210229
normal behavior/neurological phenotype J:210229
increased abdominal fat pad weight J:210229
increased adrenal gland zona fasciculata size J:210229
increased circulating adrenocorticotropin level J:210229
increased circulating insulin level J:210229
increased circulating leptin level J:210229
increased susceptibility to age related obesity J:210229
Ntrk2tm1Mini/Ntrk2tm1Mini
involves: 129P2/OlaHsd 		abnormal excitatory postsynaptic potential J:130626
abnormal long-term potentiation J:130626
impaired synaptic plasticity J:130626
Ntrk2tm1Rohr/Ntrk2+
Not Specified 		abnormal circulating corticosterone level J:179918
decreased circulating adrenocorticotropin level J:179918
decreased circulating corticosterone level J:179918
decreased circulating follicle stimulating hormone level J:88782
Ntrk2tm1Rohr/Ntrk2tm1Rohr
involves: ICR 		abnormal breathing pattern J:89227
abnormal eyelid morphology J:89227
abnormal pupillary reflex J:89227
abnormal retina development J:89227
abnormal retina rod cell outer segment morphology J:89227
abnormal rod electrophysiology J:89227
abnormal vision J:89227
decreased amacrine cell number J:89227
decreased body size J:89227
impaired righting response J:89227
postnatal lethality, complete penetrance J:89227
Ntrk2tm1Rohr/Ntrk2tm1Rohr
Not Specified 		abnormal optic nerve morphology J:119332
decreased body weight J:119332
decreased circulating follicle stimulating hormone level J:88782
decreased granulosa cell proliferation J:88782
decreased secondary ovarian follicle number J:88782
impaired granulosa cell differentiation J:88782
impaired ovarian folliculogenesis J:88782
postnatal lethality, complete penetrance J:119332
Ntrk2tm2.1Ddg/Ntrk2tm2.1Ddg
involves: 129P2/OlaHsd 		abnormal mammary gland sensory innervation pattern J:192549
Ntrk2tm2.1Ddg/Ntrk2tm2.1Ddg
involves: 129S6/SvEvTac 		abnormal survival J:218012
Ntrk2tm2.1Ddg/Ntrk2tm2.1Ddg
involves: 129S6/SvEvTac * C57BL/6 		neonatal lethality, complete penetrance J:196548
Ntrk2tm2.1Mini/Ntrk2tm2.1Mini
involves: 129P2/OlaHsd 		abnormal axon fasciculation J:132562
abnormal cerebral cortex morphology J:132562
abnormal neuron differentiation J:132562
abnormal neuronal migration J:132562
abnormal vestibular labyrinth morphology J:132562
astrocytosis J:132562
postnatal growth retardation J:132562
postnatal lethality, complete penetrance J:132562
Ntrk2tm2.1Tes/Ntrk2tm2.1Tes
involves: 129S4/SvJae * C57BL/6J 		abnormal axon extension J:193542
abnormal response to novel object J:193542
abnormal spatial working memory J:193542
normal behavior/neurological phenotype J:193542
normal nervous system phenotype J:193542
reduced long-term potentiation J:193542
Ntrk2tm2Kln/Ntrk2tm2Kln
involves: 129S2/SvPas 		no abnormal phenotype detected J:58229
Ntrk2tm2Kln/Ntrk2tm2Kln
Tg(Camk2a-cre)159Kln/?
involves: 129S2/SvPas * CBA/J 		abnormal long-term potentiation J:130626
impaired synaptic plasticity J:130626
Ntrk2tm2Kln/Ntrk2tm2Kln
Tg(Cck-cre,-lacZ)1Mini/0
involves: 129S2/SvPas * C57BL/6 * CBA 		abnormal adipose tissue distribution J:210229
abnormal circadian behavior J:210229
abnormal circulating corticosterone level J:210229
abnormal GABAergic neuron physiology J:210229
abnormal lipid level J:210229
normal adipose tissue phenotype J:210229
adrenal cortical hyperplasia J:210229
normal behavior/neurological phenotype J:210229
hepatic steatosis J:210229
normal homeostasis/metabolism phenotype J:210229
impaired glucose tolerance J:210229
increased abdominal fat pad weight J:210229
increased adrenal gland zona fasciculata size J:210229
increased body weight J:210229
increased circulating insulin level J:210229
increased circulating leptin level J:210229
increased gonadal fat pad weight J:210229
increased liver weight J:210229
increased susceptibility to age related obesity J:210229
increased susceptibility to weight gain J:210229
increased total body fat amount J:210229
Ntrk2tm2Kln/Ntrk2tm2Kln
Tg(Nes-cre)1Kln/0
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal axon fasciculation J:132562
abnormal brain morphology J:132562
abnormal cerebral cortex morphology J:132562
abnormal cortical plate morphology J:132562
abnormal myelin sheath morphology J:132562
abnormal neuron differentiation J:132562
abnormal neuronal migration J:132562
abnormal somatosensory cortex morphology J:132562
abnormal visual cortex morphology J:132562
demyelination J:132562
hyperactivity J:132562
postnatal growth retardation J:132562
premature death J:132562
Ntrk2tm2Kln/Ntrk2tm2Kln
Tg(Penk-cre,-lacZ)1Mini/0
involves: 129S2/SvPas 		abnormal gait J:204429
normal behavior/neurological phenotype J:204429
enhanced behavioral response to cocaine J:204429
increased locomotor activity J:204429
induced hyperactivity J:204429
normal nervous system phenotype J:204429
Ntrk2tm2Lfp/Ntrk2tm2Lfp
Tg(Col2a1-cre)1Bhr/0
involves: 129 * C57BL/6 * SJL 		decreased birth body size J:204227
decreased body length J:204227
decreased body size J:204227
decreased body weight J:204227
decreased long bone epiphyseal plate size J:204227
decreased width of hypertrophic chondrocyte zone J:204227
kyphosis J:204227
postnatal growth retardation J:204227
postnatal lethality, incomplete penetrance J:204227
Ntrk2tm2Lfr/Ntrk2tm2Lfr
Tg(Six3-cre)69Frty/?
Tg(Thy1-YFP)HJrs/?
involves: C57BL/6 * CBA * DBA/2 		abnormal dendrite morphology J:122929
abnormal retina ganglion cell morphology J:122929
Ntrk2tm3.1(cre/ERT2)Ddg/Ntrk2tm3.1(cre/ERT2)Ddg
involves: 129S6/SvEvTac * C57BL/6 		abnormal survival J:218012
Ntrk2tm4.1Ddg/Ntrk2tm4.1Ddg
Aviltm2(cre)Fawa/Avil+
involves: 129P2/OlaHsd * C57BL/6 		abnormal mammary gland sensory innervation pattern J:192549
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory