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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lyn
LYN proto-oncogene, Src family tyrosine kinase
MGI:96892
111 phenotypes from 14 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Lynm1Anu/\Lynm1Anu
C57BL/6JAnu-Lynm1Anu 		decreased B cell number J:195155
\LynM1Btlr/\Lyn+
C57BL/6J-LynM1Btlr 		decreased B cell number J:214511
increased neutrophil cell number J:214511
\LynM1Btlr/\LynM1Btlr
C57BL/6J-LynM1Btlr 		decreased B cell number J:214511
increased neutrophil cell number J:214511
\Lynm2Anu/\Lynm2Anu
C57B/6JAnu-Lynm2Anu/AnuApb 		decreased mature B cell number J:104190
increased immature B cell number J:104190
\LynM2Btlr/\Lyn+
C57BL/6J-LynM2Btlr 		decreased IgG level J:217146
decreased IgM level J:217146
impaired humoral immune response J:217146
\LynM2Btlr/\LynM2Btlr
C57BL/6J-LynM2Btlr 		decreased IgG level J:217146
decreased IgM level J:217146
impaired humoral immune response J:217146
\LynM3Btlr/\Lyn+
C57BL/6J-LynM3Btlr 		decreased T cell number J:236679
impaired hematopoiesis J:236679
increased B-1 B cell number J:236679
increased dendritic cell number J:236679
increased macrophage cell number J:236679
\LynM3Btlr/\LynM3Btlr
C57BL/6J-LynM3Btlr 		decreased T cell number J:236679
impaired hematopoiesis J:236679
increased B-1 B cell number J:236679
increased dendritic cell number J:236679
increased macrophage cell number J:236679
\Lynm4Btlr/\Lynm4Btlr
C57BL/6J-Lynm4Btlr 		decreased IgG level J:272816
impaired humoral immune response J:272816
\Lynmld4/\Lynmld4
involves: C57BL/6 		abnormal B cell activation J:144799
abnormal B cell morphology J:144799
abnormal myelopoiesis J:144799
decreased follicular B cell number J:144799
decreased marginal zone B cell number J:144799
decreased transitional stage B cell number J:144799
glomerulonephritis J:144799
increased anti-double stranded DNA antibody level J:144799
increased erythroid progenitor cell number J:144799
increased IgE level J:144799
increased IgM level J:144799
increased macrophage cell number J:144799
increased neutrophil cell number J:144799
increased T cell number J:144799
peritoneal inflammation J:144799
renal glomerular immunoglobulin deposits J:144799
spleen hypoplasia J:144799
\Lyntm1.1Calo/\Lyntm1.1Calo
\Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal circulating chemokine level J:200745
abnormal circulating cytokine level J:200745
abnormal dendritic cell physiology J:200745
abnormal leukocyte physiology J:200745
abnormal T cell activation J:200745
enlarged lymph nodes J:200745
enlarged spleen J:200745
glomerulonephritis J:200745
increased activated T cell number J:200745
increased autoantibody level J:200745
increased circulating interferon-gamma level J:200745
increased circulating interleukin-1 beta level J:200745
increased circulating interleukin-6 level J:200745
increased circulating interleukin-12 level J:200745
increased circulating interleukin-17 level J:200745
increased circulating tumor necrosis factor level J:200745
increased dendritic cell number J:200745
increased granulocyte number J:200745
increased inflammatory response J:200745
increased leukocyte cell number J:200745
increased monocyte cell number J:200745
increased plasma cell number J:200745
increased T cell number J:200745
liver inflammation J:200745
lung inflammation J:200745
lymph node hyperplasia J:200745
myeloid hyperplasia J:200745
premature death J:200745
renal glomerular immunoglobulin deposits J:200745
skin inflammation J:200745
skin lesions J:200745
\Lyntm1Ard/\Lyntm1Ard
B6.129P2-Lyntm1Ard 		abnormal B cell activation J:144799
abnormal B cell morphology J:144799
abnormal myelopoiesis J:144799
decreased follicular B cell number J:144799
decreased marginal zone B cell number J:144799
decreased transitional stage B cell number J:144799
glomerulonephritis J:144799
increased anti-double stranded DNA antibody level J:144799
increased anti-nuclear antigen antibody level J:144799
increased T cell number J:144799
peritoneal inflammation J:144799
renal glomerular immunoglobulin deposits J:144799
spleen hypoplasia J:144799
\Lyntm1Ard/\Lyntm1Ard
involves: 129P2/OlaHsd 		abnormal circulating complement protein level J:161523
abnormal level of surface class II molecules J:161523
albuminuria J:161523
decreased spleen red pulp amount J:72269
decreased spleen white pulp amount J:72269
enlarged spleen J:72269
extramedullary hematopoiesis J:72269
glomerulonephritis J:161523
increased anti-double stranded DNA antibody level J:161523
increased anti-nuclear antigen antibody level J:161523
increased basophil cell number J:161523
increased IgA level J:161523
increased IgE level J:161523
increased IgG2b level J:161523
increased IgM level J:161523
increased mast cell number J:161523
increased neutrophil cell number J:72269
thrombocytopenia J:72269
\Lyntm1b(EUCOMM)Hmgu/\Lyntm1b(EUCOMM)Hmgu
C57BL/6N-Lyntm1b(EUCOMM)Hmgu/H 		abnormal gait J:211773
abnormal maxilla morphology J:211773
abnormal retina morphology J:211773
decreased bone mineral density J:211773
decreased circulating cholesterol level J:211773
decreased circulating HDL cholesterol level J:211773
decreased circulating triglyceride level J:211773
decreased erythrocyte cell number J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
decreased leukocyte cell number J:211773
decreased lymphocyte cell number J:211773
enlarged spleen J:211773
increased blood urea nitrogen level J:211773
increased circulating aspartate transaminase level J:211773
increased eosinophil cell number J:211773
increased large unstained cell number J:211773
increased mean platelet volume J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
increased red blood cell distribution width J:211773
increased spleen weight J:211773
small thymus J:211773
thrombocytopenia J:211773
\Lyntm1Mhi/\Lyntm1Mhi
involves: 129S1/Sv 		decreased spleen weight J:72269
increased neutrophil cell number J:72269
\Lyntm1Sor/\Lyntm1Sor
B6.129S4-Lyntm1Sor 		abnormal inflammatory response J:113463
\Lyntm1Sor/\Lyntm1Sor
involves: 129S4/SvJae 		decreased B cell number J:42037
decreased mature B cell number J:42037
enlarged lymph nodes J:42037
enlarged spleen J:42037
increased anti-double stranded DNA antibody level J:42037
increased B cell proliferation J:42037
\Lyntm1Sor/\Lyntm1Sor
involves: 129S4/SvJaeSor 		abnormal chemokine level J:80658
abnormal circulating chemokine level J:200745
abnormal circulating cytokine level J:200745
abnormal dendritic cell physiology J:200745
abnormal macrophage physiology J:80658
abnormal microglial cell physiology J:80658
abnormal proerythroblast morphology J:146561
decreased B cell number J:200745
decreased follicular B cell number J:146161
decreased marginal zone B cell number J:146161
decreased mature B cell number J:146161
decreased transitional stage B cell number J:146161
glomerulonephritis J:146161, J:200745
glomerulosclerosis J:146161
increased anti-double stranded DNA antibody level J:146161
increased autoantibody level J:200745
increased B cell proliferation J:146161
increased circulating interferon-gamma level J:200745
increased circulating interleukin-6 level J:200745
increased circulating interleukin-12 level J:200745
increased circulating interleukin-17 level J:200745
increased erythroid progenitor cell number J:146561
increased IgA level J:146161
increased IgM level J:146161
increased plasma cell number J:200745
liver inflammation J:146161
mesangial cell interposition J:146161
myeloid hyperplasia J:146161
renal glomerular protein deposits J:200745
renal glomerulus hypertrophy J:146161
spleen hyperplasia J:146161
\Lyntm1Sor/\Lyntm1Sor
involves: 129S4/SvJaeSor * C57BL/6 		decreased B cell number J:71174
decreased B-1 B cell number J:71174
decreased mature B cell number J:71174
enlarged spleen J:71174
glomerulonephritis J:71174
increased anti-double stranded DNA antibody level J:71174
increased B cell proliferation J:71174
increased IgA level J:71174
increased IgG1 level J:71174
increased IgG2b level J:71174
increased IgG level J:71174
increased IgM level J:71174
increased susceptibility to systemic lupus erythematosus J:71174
\Lyntm1Tya/\Lyntm1Tya
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell physiology J:29751
abnormal class switch recombination J:29751
abnormal spleen morphology J:29751
anemia J:29751
decreased B cell number J:29751
decreased B cell proliferation J:29751
decreased lymphocyte cell number J:29751
enlarged lymph nodes J:29751
enlarged spleen J:29751
glomerulonephritis J:29751
increased anti-double stranded DNA antibody level J:29751
increased IgA level J:29751
increased IgM level J:29751
increased immunoglobulin level J:29751
increased spleen white pulp amount J:29751
premature death J:29751
small Peyer's patches J:29751
\Lynweeb/\Lynweeb
C57BL/6-Lynweeb 		decreased follicular B cell number J:146161
decreased marginal zone B cell number J:146161
decreased mature B cell number J:146161
decreased transitional stage B cell number J:146161
disorganized spleen B cell follicle J:146161
glomerulonephritis J:146161
glomerulosclerosis J:146161
increased anti-double stranded DNA antibody level J:146161
increased B cell proliferation J:146161
increased IgM level J:146161
liver inflammation J:146161
mesangial cell interposition J:146161
renal glomerulus hypertrophy J:146161
spleen hyperplasia J:146161
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory