Lyn^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lyn^M2Btlr
• Name: LYN proto-oncogene, Src family tyrosine kinase; mutation 2, Bruce Beutler
• MGI ID: MGI:5613173
• Synonyms: Cress
• Gene: Lyn Location: Chr4:3676865-3791612 bp, + strand Genetic Position: Chr4, 2.05 cM
• Alliance: Lyn^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion at base pair 3,789,908 (v38) on chromosome 4, or base pair 111,788 in the GenBank genomic region NC_000070. The mutation corresponds to residue 1,752 in the mRNA sequence NM_001111096 within exon 13 of 13 total exons and residue 1,689 in the mRNA sequence NM_010747 within exon 13 of 13 total exons. The mutation results in substitution of tyrosine 501 (Tyr501) for a premature stop codon (Tyr501*) in the Lynp56 protein and a Tyr480* in the Lynp53 protein. (J:217146)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyn Mutation: 64 strains or lines available

References

• Original: J:217146 Wang KW, et al., Mutagenetix entry for Cress. MGI Direct Data Submission. 2015
• All: 1 reference(s)