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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		LynM2Btlr
mutation 2, Bruce Beutler
MGI:5613173
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		LynM2Btlr/LynM2Btlr C57BL/6J-LynM2Btlr MGI:5613180
ht2
 		LynM2Btlr/Lyn+ C57BL/6J-LynM2Btlr MGI:5613181


Genotype
MGI:5613180
hm1
Allelic
Composition		 LynM2Btlr/LynM2Btlr
Genetic
Background		 C57BL/6J-LynM2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LynM2Btlr mutation (0 available); any Lyn mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG level ( J:217146 )
• diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFVbeta-gal)
• diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum)
decreased IgM level ( J:217146 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
impaired humoral immune response ( J:217146 )
• diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum)
• diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFVbeta-gal)
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
decreased IgG level ( J:217146 )
• diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFVbeta-gal)
• diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum)
decreased IgM level ( J:217146 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Genotype
MGI:5613181
ht2
Allelic
Composition		 LynM2Btlr/Lyn+
Genetic
Background		 C57BL/6J-LynM2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
LynM2Btlr mutation (0 available); any Lyn mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgG level ( J:217146 )
• diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFVbeta-gal)
• diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum)
decreased IgM level ( J:217146 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

immune system
decreased IgG level ( J:217146 )
• diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFVbeta-gal)
• diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum)
decreased IgM level ( J:217146 )
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
impaired humoral immune response ( J:217146 )
• diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide (OVA/Alum)
• diminished T-dependent response to recombinant Semliki Forest virus (rSFV)-encoded -galactosidase (rSFVbeta-gal)
• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory