Lyn^M3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lyn^M3Btlr
• Name: LYN proto-oncogene, Src family tyrosine kinase; mutation 3, Bruce Beutler
• MGI ID: MGI:5806331
• Synonyms: Pacific
• Gene: Lyn Location: Chr4:3676865-3791612 bp, + strand Genetic Position: Chr4, 2.05 cM
• Alliance: Lyn^M3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to T transversion at base pair 3,745,330 (v38) on chromosome 4, or base pair 67,210 in the GenBank genomic region NC_000070. The mutation corresponds to residue 546 in the mRNA sequence NM_001111096 (variant 1) within exon 5 of 13 total exons as well as residue 483 in the mRNA sequence NM_10747 (variant 2) within exon 5 or 13 total exons. The mutation results in a tryptophan (W) to cysteine (C) substitution at position 99 (W99C) in the protein. (J:236679)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyn Mutation: 64 strains or lines available

References

• Original: J:236679 Zeng M, et al., Mutagenetix entry for Pacific. MGI Direct Data Submission. 2016
• All: 1 reference(s)