All Phenotypes Lyn<M3Btlr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lyn^M3Btlr
mutation 3, Bruce Beutler
MGI:5806331

Summary

2 genotypes

Allelic Composition	Lyn^M3Btlr/Lyn^M3Btlr
Genetic Background	C57BL/6J-Lyn^M3Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^M3Btlr mutation (0 available); any Lyn mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

impaired hematopoiesis ( J:236679 )

increased dendritic cell number ( J:236679 )

increased B-1 B cell number ( J:236679 )

decreased T cell number ( J:236679 )

• a reduced frequency of T cells including CD4+ T cells and CD8+ T cells, all in the peripheral blood

increased macrophage cell number ( J:236679 )

immune system

increased dendritic cell number ( J:236679 )

increased B-1 B cell number ( J:236679 )

decreased T cell number ( J:236679 )

• a reduced frequency of T cells including CD4+ T cells and CD8+ T cells, all in the peripheral blood

increased macrophage cell number ( J:236679 )

Allelic Composition	Lyn^M3Btlr/Lyn⁺
Genetic Background	C57BL/6J-Lyn^M3Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^M3Btlr mutation (0 available); any Lyn mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

impaired hematopoiesis ( J:236679 )

• slight

increased dendritic cell number ( J:236679 )

increased B-1 B cell number ( J:236679 )

decreased T cell number ( J:236679 )

• a reduced frequency of T cells including CD4+ T cells and CD8+ T cells, all in the peripheral blood

increased macrophage cell number ( J:236679 )

immune system

increased dendritic cell number ( J:236679 )

increased B-1 B cell number ( J:236679 )

decreased T cell number ( J:236679 )

• a reduced frequency of T cells including CD4+ T cells and CD8+ T cells, all in the peripheral blood

increased macrophage cell number ( J:236679 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23