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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il2rg
interleukin 2 receptor, gamma chain
MGI:96551
54 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\B2mtm1Unc/\B2mtm1Unc
\Il2rgtm1.1Asin/\Il2rgtm1Wjl
\Tg(Cd8a*-cre)B8Asin/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		decreased CD8-positive, alpha-beta T cell number J:190889
\Csf1tm1.1(CSF1)Flv/\Csf1tm1.1(CSF1)Flv
\Csf2/Il3tm1.1(CSF2,IL3)Flv/\Csf2/Il3tm1.1(CSF2,IL3)Flv
\Il2rgtm1.1Flv/\Il2rgtm1.1Flv
\Rag2tm1.1Flv/\Rag2tm1.1Flv
\Tg(SIRPA)1Flv/0
\Thpotm1.1(TPO)Flv/\Thpotm1.1(TPO)Flv
involves: 129S4/SvJae * BALB/cAnNTac 		abnormal response to transplant J:207289
\Csf1tm1.1(CSF1)Flv/\Csf1tm1.1(CSF1)Flv
\Csf2/Il3tm1.1(CSF2,IL3)Flv/\Csf2/Il3tm1.1(CSF2,IL3)Flv
\Il2rgtm1.1Flv/\Il2rgtm1.1Flv
\Rag2tm1.1Flv/\Rag2tm1.1Flv
\Thpotm1.1(TPO)Flv/\Thpotm1.1(TPO)Flv
involves: 129S4/SvJae * BALB/cAnNTac 		abnormal response to transplant J:207289
\Csf1tm1.1(CSF1)Flv/\Csf1tm1.1(CSF1)Flv
\Il2rgtm1.1Flv/\Il2rgtm1.1Flv
\Csf2/Il3tm1.1(CSF2,IL3)Flv/\Csf2/Il3tm1.1(CSF2,IL3)Flv
\Rag2tm1.1Flv/\Rag2tm1.1Flv
\Tg(SIRPA)1Flv/0
\Thpotm1.1(TPO)Flv/\Thpotm1.1(TPO)Flv
involves: 129S4/SvJae * BALB/cAnNTac 		abnormal response to transplant J:207289
\Csf1tm1.1(CSF1)Flv/\Csf1tm1.1(CSF1)Flv
\Il2rgtm1.1Flv/\Il2rgtm1.1Flv
\Csf2/Il3tm1.1(CSF2,IL3)Flv/\Csf2/Il3tm1.1(CSF2,IL3)Flv
\Rag2tm1.1Flv/\Rag2tm1.1Flv
\Thpotm1.1(TPO)Flv/\Thpotm1.1(TPO)Flv
involves: 129S4/SvJae * BALB/cAnNTac 		abnormal response to transplant J:207289
\Csf1tm1.1(CSF1)Flv/\Csf1tm1.1(CSF1)Flv
\Il2rgtm1.1Flv/\Il2rgtm1.1Flv
\Rag2tm1.1Flv/\Rag2tm1.1Flv
involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * BALB/cAnNTac 		abnormal immune system physiology J:177073
normal craniofacial phenotype J:177073
normal hematopoietic system phenotype J:177073
normal immune system phenotype J:177073
normal skeleton phenotype J:177073
\Csf2/Il3tm1.1(CSF2,IL3)Flv/\Csf2/Il3tm1.1(CSF2,IL3)Flv
\Il2rgtm1.1Flv/\Il2rgtm1.1Flv
\Rag2tm1.1Flv/\Rag2tm1.1Flv
involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac 		abnormal response to transplant J:168302
\Del(7Pira1-Lilra6)1Fgla/\Del(7Pira1-Lilra6)1Fgla
\Il2rgtm1Wjl/\Il2rgtm1Wjl
\Rag2tm1Fwa/\Rag2tm1Fwa
involves: C57BL/6J * C57BL/6NTac 		abnormal response to transplant J:290663
\Il2rgtm1.1Asin/\Il2rgtm1Wjl
\Tg(Cd8a*-cre)B8Asin/0
\Tg(LCKprBCL2)36Sjk/0
involves: 129S4/SvJae * C57BL/6 		decreased NK T cell number J:190889
\Il2rgtm1.1Flv/\Il2rgtm1.1Flv
\Csf2/Il3tm1.1(CSF2,IL3)Flv/\Csf2/Il3tm1.1(CSF2,IL3)Flv
\Rag2tm1.1Flv/\Rag2tm1.1Flv
involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac 		abnormal response to transplant J:168302
\Il2rgtm1.1Flv/\Il2rgtm1.1Flv
\Rag2tm1.1Flv/\Rag2tm1.1Flv
involves: 129S4/SvJae * BALB/cAnNTac 		abnormal response to transplant J:168303
increased susceptibility to bacterial infection J:168303
\Il2rgtm1.1Flv/\Il2rgtm1.1Flv
\Rag2tm1.1Flv/\Rag2tm1.1Flv
\Thpotm1.1(TPO)Flv/\Thpotm1.1(TPO)Flv
involves: 129S4/SvJae * BALB/cAnNTac 		abnormal response to transplant J:168301
thrombocytopenia J:168301
\Il2rgtm1.1Flv/Y
\Rag2tm1.1Flv/\Rag2tm1.1Flv
involves: 129S4/SvJae * BALB/cAnNTac 		abnormal response to transplant J:168303
increased susceptibility to bacterial infection J:168303
\Il2rgtm1Cgn/\Il2rgtm1Cgn
\Kittm1.1Bsm/\Kittm1.1Bsm
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		arrested T cell differentiation J:90485
\Il2rgtm1Cgn/\Il2rgtm1Cgn
\Rag2tm1Fwa/\Rag2tm1Fwa
involves: 129P2/OlaHsd * 129S/SvEv 		abnormal interleukin secretion J:142654
decreased NK cell number J:142654
increased susceptibility to bacterial infection J:142654
\Il2rgtm1Cgn/Y
\Rag2tm1Fwa/\Rag2tm1Fwa
B6.129-Rag2tm1Fwa Il2rgtm1Cgn 		absent B cells J:132257
absent NK cells J:132257
absent T cells J:132257
\Il2rgtm1Krf/\Il2rgtm1Krf
\Tg(BCL2/IGH)1Tjd/0
either: (involves: 129P2/OlaHsd * C3H/He * C57BL/6) or (involves: 129P2/OlaHsd * C3H/He * C57BL/6 * FVB/N) 		decreased thymocyte number J:114561
\Il2rgtm1Krf/\Il2rgtm1Krf
\Tg(Igh-Pim1)1Brn/0
either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N) 		decreased thymocyte number J:114561
\Il2rgtm1Wjl/Y
\Crlf2tm1Wjl/\Crlf2tm1Wjl
involves: 129S4/SvJae * C57BL/6 		thymus hypoplasia J:108209
\Il2rgtm1Wjl/\Il2rgtm1Wjl
\Prkdcscid/\Prkdcscid
NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz 		abnormal glucose homeostasis J:138005
abnormal immune system organ morphology J:109833
abnormal response to transplant J:109833
abnormal splenic cell ratio J:109833
abnormal thymus morphology J:109833
decreased CD4-positive, alpha-beta T cell number J:109833
decreased CD8-positive, alpha-beta T cell number J:109833
decreased immature B cell number J:109833
decreased immunoglobulin level J:109833
decreased incidence of tumors by ionizing radiation induction J:109833
decreased leukocyte cell number J:109833
decreased mature B cell number J:109833
decreased mean corpuscular volume J:109833
decreased NK cell number J:109833
decreased spleen B cell follicle number J:109833
hyperglycemia J:138005
increased cellular sensitivity to X-ray irradiation J:109833
lymph node hypoplasia J:109833
premature death J:109833
small lymph nodes J:109833
thymus cyst J:109833
\Il2rgtm1Wjl/\Il2rgtm1Wjl
\Rag2tm1Fwa/\Rag2tm1Fwa
involves: 129S/SvEv * 129S4/SvJae 		abnormal interferon secretion J:140483
absent NK cells J:140483
absent T cells J:140483
increased susceptibility to bacterial infection J:140483
increased susceptibility to induced morbidity/mortality J:140483
lung inflammation J:140483
\Il2rgtm1Wjl/\Il2rgtm1Wjl
\Tg(CD2-Ccdc86)1Hfuj/?
B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj 		decreased CD4-positive, alpha-beta T cell number J:151722
decreased CD8-positive, alpha-beta T cell number J:151722
decreased regulatory T cell number J:151722
decreased splenocyte number J:151722
normal immune system phenotype J:151722
\Il2rgtm1Wjl/Y
\Prkdcscid/\Prkdcscid
NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz 		abnormal immune system organ morphology J:109833
abnormal response to transplant J:109833, J:140388
abnormal splenic cell ratio J:109833
abnormal thymus morphology J:109833
decreased CD4-positive, alpha-beta T cell number J:109833
decreased CD8-positive, alpha-beta T cell number J:109833
decreased immature B cell number J:109833
decreased immunoglobulin level J:109833
decreased leukocyte cell number J:109833
decreased mature B cell number J:109833
decreased mean corpuscular volume J:109833
decreased NK cell number J:109833
decreased spleen B cell follicle number J:109833
increased cellular sensitivity to X-ray irradiation J:109833
lymph node hypoplasia J:109833
premature death J:109833
small lymph nodes J:109833
\Il2rgtm1Wjl/Y
\Rag1tm1Mom/\Rag1tm1Mom
NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ 		abnormal adaptive immunity J:140388
abnormal innate immunity J:140388
abnormal response to transplant J:140388
abnormal spleen morphology J:140388
abnormal thymus morphology J:140388
absent NK T cells J:140388
absent thymus cortex J:140388
absent thymus medulla J:140388
decreased macrophage cell number J:140388
decreased spleen B cell follicle number J:140388
thymus cyst J:140388
\Rag2tm1Fwa/\Rag2tm1Fwa
\Cd47tm1Fpl/\Cd47tm1Fpl
\Il2rgtm1Cgn/Y
involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * C57BL/6 		absent peripheral lymph nodes J:203904
decreased CD4-positive, alpha-beta T cell number J:203904
decreased lymphocyte cell number J:203904
decreased susceptibility to graft versus host disease J:203904
increased activated T cell number J:203904
increased CD8-positive, alpha-beta T cell number J:203904
increased susceptibility to Retroviridae infection J:203904
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory