Csf1^{tm1.1(CSF1)Flv}
Targeted Allele Detail

Summary

• Symbol: Csf1^{tm1.1(CSF1)Flv}
• Name: colony stimulating factor 1 (macrophage); targeted mutation 1.1, Richard A Flavell
• MGI ID: MGI:5296679
• Synonyms: CSF1^h, Csf1^{tm1.1(CSF1)Vlcg}
• Gene: Csf1 Location: Chr3:107648364-107667785 bp, - strand
• Alliance: Csf1^{tm1.1(CSF1)Flv} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177073
• Parent Cell Line: v17.2 (ES Cell)
• Strain of Origin: (BALB/cJ x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The mouse open reading frame (exon 2 through 9) was replaced with the human gene from BAC RPCI-11, clone 101M23. A floxed neo cassette inserted downstream of the human sequence was removed by cre-mediated recombination. (J:177073)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csf1 Mutation: 45 strains or lines available

Notes

This allele was originally generated in v17.2 ES cells homozygous for Il2rg^tm1Cgn and Rag2^tm1Fwa.

References

• Original: J:177073 Rathinam C, et al., Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood. 2011 Sep 15;118(11):3119-28
• All: 8 reference(s)