Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Il2rgtm1Cgn
Name:	interleukin 2 receptor, gamma chain; targeted mutation 1, University of Cologne
MGI ID:	MGI:1861947
Synonyms:	cgamma-, gamma-, gammac-, gc-, Il2rg-, IL-2Rgamma-, Il2rgtm1Rsky
Gene:	Il2rg  Location: ChrX:100307991-100311861 bp, - strand  Genetic Position: ChrX, 43.9 cM
Alliance:	Il2rgtm1Cgn page

Germline Transmission:	Earliest citation of germline transmission: J:22521
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Insertion of a neomycin resistance cassette flanked by lox P sites, followed by homologous recombination and cre-mediated deletion, resulted in the excision of exons 2 - 6 of the gene. These exons encode the extracellular and transmembrane domains of the protein. (J:22521)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Il2rg Mutation:	168 strains or lines available

Original:	J:22521 DiSanto JP, et al., Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):377-81
All:	123 reference(s)