Tg(CD2-Ccdc86)1Hfuj
Transgene Detail

Summary

• Symbol: Tg(CD2-Ccdc86)1Hfuj
• Name: transgene insertion 1, Hodaka Fujii
• MGI ID: MGI:4356279
• Synonyms: Cyclon-Tg, HA-Cyclon
• Transgene: Tg(CD2-Ccdc86)1Hfuj Location: unknown
• Alliance: Tg(CD2-Ccdc86)1Hfuj page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-Ccdc86)1Hfuj expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ccdc86 (MGI:1277220)

• Tg(CD2-Ccdc86)1Hfuj expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  CD2 (914)

  Cd2	(MGI:88320)

• Mutation details: Murine Ccdc86 coding sequence was inserted into the VA-hCD2 expression vector and the resulting transgene was injected into the pronuclei of fertilized eggs. mRNA and protein expression was confirmed by RT-PCR and immunoblot analysis of splenocytes. Expression level of the transgene product was 1.7 and 1.49 fold greater than endogenous protein in CD4⁺ or CD8⁺ T cells. The n-terminus of the protein product is tagged by an HA epitope tag. (J:151722)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:151722 Saint Fleur S, et al., Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Blood. 2009 Aug 13;114(7):1355-65
• All: 1 reference(s)