Phenotypes associated with this allele
immune system
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• absence of the Fas receptor prevents the transgene from rescuing the splenomegaly associated with Il2ratm1Dw homozygotes
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hematopoietic system
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• absence of the Fas receptor prevents the transgene from rescuing the splenomegaly associated with Il2ratm1Dw homozygotes
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growth/size/body
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• absence of the Fas receptor prevents the transgene from rescuing the splenomegaly associated with Il2ratm1Dw homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2ratm1Dw mutation
(3 available);
any
Il2ra mutation
(51 available)
Tg(CD2-Ccdc86)1Hfuj mutation
(1 available)
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immune system
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N |
• the presence of the transgene prevents the splenomegaly, the large number of T cells, and high circulating levels of IL-17 normally found in Il2ratm1Dw homozygotes
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• high expression of CD44 and CD69 suggests the transgene does not prevent the aberrant activation of peripheral T cells
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hematopoietic system
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• high expression of CD44 and CD69 suggests the transgene does not prevent the aberrant activation of peripheral T cells
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immune system
 N |
• the presence of the transgene prevents the splenomegaly associated with Il2rgtm1Wjl homozygotes due to decreased lymphocyte numbers and size
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• CD4 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
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• CD8 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
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• the transgene fails to rescue the decreased numbers of FoxP3+ regulatory T cells associated with Il2rgtm1Wjl homozygotes
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• splenocyte number is decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
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hematopoietic system
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• CD4 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
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• CD8 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
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• the transgene fails to rescue the decreased numbers of FoxP3+ regulatory T cells associated with Il2rgtm1Wjl homozygotes
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• splenocyte number is decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD2-Ccdc86)1Hfuj mutation
(1 available)
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immune system
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• CD4+ and CD8+ T cells have increased rates of activation induced cell death upon secondary stimulation
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• T cells have increased expression of the Fas receptor
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hematopoietic system
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• CD4+ and CD8+ T cells have increased rates of activation induced cell death upon secondary stimulation
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• T cells have increased expression of the Fas receptor
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cellular
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• CD4+ and CD8+ T cells have increased rates of activation induced cell death upon secondary stimulation
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Analysis Tools