81 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Chd7Whi/Chd7+ Fgfr1Hspy/Fgfr1+ C3HeB/FeJ-Chd7Whi Fgfr1Hspy	abnormal heart morphology	J:161880
	choanal atresia	J:161880
	cleft palate	J:161880
	normal nervous system phenotype	J:161880
	perinatal lethality, complete penetrance	J:161880
	preweaning lethality, complete penetrance	J:161880
	normal reproductive system phenotype	J:161880
Cpa3tm3(icre)Hrr/Cpa3+ Fgfr1tm1Upir/Fgfr1tm1Upir Fgfr2tm1Dor/Fgfr2tm1Dor Tg(KRT5-cre)5132Jlj/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J	absent mast cells	J:221184
	acanthosis	J:221184
	decreased body weight	J:221184
	female infertility	J:221184
	impaired skin barrier function	J:221184
	increased keratinocyte proliferation	J:221184
	progressive hair loss	J:221184
	reduced male fertility	J:221184
	skin inflammation	J:221184
Fgfr1tm1.1Jpa/Fgfr1+ Spry2tm1.1Mrt/Spry2tm1.1Mrt involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	supernumerary teeth	J:119280
Fgfr1tm1.1Jpa/Fgfr1+ Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+ Tg(Prrx1-cre)1Cjt/0 involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster	abnormal limb development	J:149478
Fgfr1tm1Jpa/Fgfr1+ Fgfr2tm1Dor/Fgfr2tm1.1Dor Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal small intestine morphology	J:139005
Fgfr1tm1Jpa/Fgfr1+ Fgfr2tm1Dor/Fgfr2tm1Dor Tg(Hoxb7-cre)5526Cmb/0 involves: FVB/N	abnormal kidney development	J:95018
	abnormal ureteric bud morphology	J:95018
	decreased renal glomerulus number	J:95018
	hydronephrosis	J:95018
	impaired branching involved in ureteric bud morphogenesis	J:95018
	small kidney	J:95018
Fgfr1tm1Jpa/Fgfr1+ Fgfr2tm1Dor/Fgfr2tm1Dor Tg(Pax3-cre)1Joe/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	normal renal/urinary system phenotype	J:107078
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa Fgfr2tm1Dor/Fgfr2+ Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal small intestine morphology	J:139005
Fgfr1tm1Jpa/Fgfr1tm1.1Jpa Fgfr2tm1Dor/Fgfr2tm1.1Dor Twist2tm1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal digestive system physiology	J:139005
	abnormal small intestine crypts of Lieberkuhn morphology	J:139005
	abnormal small intestine morphology	J:139005
Fgfr1tm1Jpa/Fgfr1tm1Jpa Fgfr2tm1Dor/Fgfr2+ Tg(Pax3-cre)1Joe/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	normal renal/urinary system phenotype	J:107078
Fgfr1tm1Jpa/Fgfr1tm1Jpa Fgfr2tm1Dor/Fgfr2+ Tg(Hoxb7-cre)5526Cmb/0 involves: FVB/N	normal renal/urinary system phenotype	J:95018
Fgfr1tm1Jpa/Fgfr1tm1Jpa Fgfr2tm1Dor/Fgfr2tm1Dor involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	normal cardiovascular system phenotype	J:143444
	facial cleft	J:143444
Fgfr1tm1Jpa/Fgfr1tm1Jpa Fgfr2tm1Dor/Fgfr2tm1Dor Shhtm1(EGFP/cre)Cjt/Shh+ involves: 129S1/Sv * 129X1/SvJ	abnormal urethra urothelium morphology	J:223057
	normal reproductive system phenotype	J:223057
Fgfr1tm1Jpa/Fgfr1tm1Jpa Fgfr2tm1Dor/Fgfr2tm1Dor Tg(Hoxb7-cre)5526Cmb/0 involves: FVB/N	abnormal ureteric bud morphology	J:95018
	decreased renal glomerulus number	J:95018
	hydronephrosis	J:95018
	small kidney	J:95018
Fgfr1tm1Jpa/Fgfr1tm1Jpa Fgfr2tm1Dor/Fgfr2tm1Dor Tg(Msx2-rtTA)888Lma/0 Tg(tetO-cre)1Jaw/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal reproductive system physiology	J:223057
	genital tubercle hypoplasia	J:223057
Fgfr1tm1Jpa/Fgfr1tm1Jpa Fgfr2tm1Dor/Fgfr2tm1Dor Tg(Pax3-cre)1Joe/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal ureteric bud elongation	J:107078
	abnormal ureteric bud morphology	J:107078
	absent kidney	J:107078
	absent metanephric mesenchyme	J:107078
	decreased kidney cell proliferation	J:107078
	ectopic ureteric bud	J:107078
	impaired branching involved in ureteric bud morphogenesis	J:107078
	increased kidney apoptosis	J:107078
	increased metanephric mesenchyme apoptosis	J:107078
	small ureteric bud	J:107078
Fgfr1tm1Jpa/Fgfr1tm1Jpa Fgfr2tm1Dor/Fgfr2tm1Dor Twist2tm1.1(cre)Dor/Twist2+ involves: 129S1/Sv * 129X1/SvJ	abnormal reproductive system physiology	J:223057
	genital tubercle hypoplasia	J:223057
Fgfr1tm1Jpa/Fgfr1tm1Jpa Fgfr2tm3.1Lni/Fgfr2tm3.1Lni Tg(Pax3-cre)1Joe/0 involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL	abnormal metanephric mesenchyme morphology	J:167305
	abnormal ureteric bud invasion	J:167305
	absent kidney	J:167305
	ectopic ureteric bud	J:167305
	impaired branching involved in ureteric bud morphogenesis	J:167305
	increased metanephric mesenchyme apoptosis	J:167305
	small ureteric bud	J:167305
Fgfr1tm1Jpa/Fgfr1tm1Jpa Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J	decreased maxillary shelf size	J:298139
	small frontonasal prominence	J:298139
Fgfr1tm1Swnr/Fgfr1tm1Swnr Fgfr2tm1Dor/Fgfr2tm1Dor Tg(KRT5-cre)5132Jlj/0 involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J	abnormal skin adnexa morphology	J:158802
	acanthosis	J:158802
	decreased body size	J:158802
	progressive hair loss	J:158802
Fgfr1tm1Upir/Fgfr1tm1Upir Fgfr2tm1Dor/Fgfr2tm1Dor Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+ Myl2tm1(cre)Krc/Myl2+ involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	heart hypoplasia	J:131577
	thin ventricular wall	J:131577
Fgfr1tm1Upir/Fgfr1tm1Upir Fgfr2tm1Dor/Fgfr2tm1Dor Tg(GFAP-cre)25Mes/0 involves: 129X1/SvJ * FVB/N	abnormal astrocyte morphology	J:110263
Fgfr1tm1Upir/Fgfr1tm1Upir Fgfr2tm1Dor/Fgfr2tm1Dor Tg(KRT5-cre)5132Jlj/0 involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2J	abnormal chemokine level	J:221184
	abnormal epidermal layer morphology	J:158802
	abnormal epidermis stratum granulosum morphology	J:158802
	abnormal hair cycle	J:158802
	abnormal hair follicle morphology	J:158802
	abnormal mast cell morphology	J:221184
	abnormal skin adnexa morphology	J:158802
	abnormal skin appearance	J:158802
	absent hair follicles	J:158802
	absent sebaceous gland	J:158802
	acanthosis	J:158802, J:221184
	alopecia	J:158802
	decreased body size	J:158802
	decreased body weight	J:221184
	dermatitis	J:221184
	dry skin	J:158802
	female infertility	J:158802, J:221184
	impaired skin barrier function	J:158802, J:221184
	increased IgE level	J:158802
	increased IgG1 level	J:158802
	increased IgG2a level	J:158802
	increased keratinocyte proliferation	J:158802, J:221184
	increased mast cell number	J:221184
	polydipsia	J:158802
	progressive hair loss	J:158802, J:221184
	reduced male fertility	J:158802, J:221184
	skin fibrosis	J:158802
	skin inflammation	J:158802, J:221184
	small hair follicles	J:158802
	thick epidermis	J:221184
Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd Fgfr2tm1Dor/Fgfr2tm1Dor Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+ involves: 129S6/SvEvTac * 129X1/SvJ	abnormal vascular development	J:143444
	normal cardiovascular system phenotype	J:143444
	normal mortality/aging	J:143444
Fgfr1tm5.1Sor/Fgfr1tm10.1Sor Stat3tm2Aki/Stat3tm2Aki H2az2Tg(Wnt1-cre)11Rth/H2az2+ involves: 129P2/OlaHsd * 129S4/SvJaeSor	normal craniofacial phenotype	J:226497
Fgfr2tm1Dor/Fgfr2+ Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd Foxg1tm1(cre)Skm/Foxg1+ Fgfr1tm1Jpa/Fgfr1tm1Jpa Frs3tm1Jheb/Frs3tm1Jheb involves: 129	normal cellular phenotype	J:242687
	normal nervous system phenotype	J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd Foxg1tm1(cre)Skm/Foxg1+ Fgfr1tm6.1Jrt/Fgfr1tm1Jpa involves: 129	normal nervous system phenotype	J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd Foxg1tm1(cre)Skm/Foxg1+ Fgfr1tm1Jpa/Fgfr1tm1Jpa Frs3tm1Jheb/Frs3tm1Jheb involves: 129	absent telencephalon	J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd Foxg1tm1(cre)Skm/Foxg1+ Fgfr1tm3.1Sor/Fgfr1tm1Jpa Frs3tm1Jheb/Frs3tm1Jheb involves: 129	absent telencephalon	J:242687
	normal cellular phenotype	J:242687
	increased cell death	J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor Foxg1tm1(cre)Skm/Foxg1+ Fgfr1tm1Jpa/Fgfr1tm1Jpa involves: 129	frontonasal prominence hypoplasia	J:242687
	microphthalmia	J:242687
	telencephalon hypoplasia	J:242687
Fgfr2tm1Dor/Fgfr2tm1Dor Foxg1tm1(cre)Skm/Foxg1+ Fgfr1tm3.1Sor/Fgfr1tm1Jpa involves: 129	abnormal lateral ganglionic eminence morphology	J:242687
	abnormal medial ganglionic eminence morphology	J:242687
	frontonasal prominence hypoplasia	J:242687
	microphthalmia	J:242687
	telencephalon hypoplasia	J:242687