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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dnmt1
DNA methyltransferase 1
MGI:94912
22 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Avy/\A
\Dnmt1MommeD2/\Dnmt1+
involves: C57BL/6J * FVB/NJ 		yellow coat color J:99816
\ApcMin/\Apc+
\Dnmt1tm1Jae/\Dnmt1+
involves: 129S4/SvJae * C57BL/6J 		intestine polyps J:75230
\ApcMin/\Apc+
\Dnmt1tm1Jae/\Dnmt1tm1Pwl
involves: 129S4/SvJae * C57BL/6J 		normal digestive/alimentary phenotype J:75230
\ApcMin/\Apc+
\Dnmt1tm1Pwl/\Dnmt1+
involves: 129S4/SvJae * C57BL/6J 		intestine polyps J:75230
\Bcl11atm1Pwt/\Bcl11atm1Pwt
\Dnmt1tm2Jae/\Dnmt1+
\Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA 		anemia J:196140
decreased erythrocyte cell number J:196140
\Dmap1tm1.2Jrc/\Dmap1+
\Dnmt1tm2Jrc/\Dnmt1tm2Jrc
involves: 129S1/Sv * C57BL/6 * FVB/N * SJL 		abnormal DNA methylation J:172814
transmission ratio distortion J:172814
\Dmap1tm1.2Jrc/\Dmap1tm1.2Jrc
\Dnmt1tm2Jrc/\Dnmt1tm2Jrc
involves: 129S1/Sv * C57BL/6 * FVB/N * SJL 		embryonic lethality before implantation, complete penetrance J:172814
\Dnmt1tm1(tetO-BCL2)Sjk/\Dnmt1+
\Tg(IghMyc)22Bri/0
\Tg(MMTVtTA)1Mam/0
involves: 129S4/SvJae * C57BL/6 		enlarged spleen J:93549
increased B cell derived lymphoma incidence J:93549
increased leukemia incidence J:93549
lethargy J:93549
premature death J:93549
\Dnmt1tm1Enl/\Dnmt1tm1Enl
\H19tm1Tilg/\H19+
involves: 129S/SvEv * 129S4/SvJae 		genetic imprinting J:110857
\Dnmt1tm1Jae/\Dnmt1+
\Mlh1tm1Lisk/\Mlh1tm1Lisk
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 		increased intestinal adenocarcinoma incidence J:75745
increased intestinal adenoma incidence J:75745
increased lymphoma incidence J:75745
premature death J:75745
\Dnmt1tm1Jae/\Dnmt1tm1Pwl
\Mlh1tm1Lisk/\Mlh1tm1Lisk
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 		increased lymphoma incidence J:75745
normal neoplasm J:75745
premature death J:75745
\Dnmt1tm1Pwl/\Dnmt1+
\Mlh1tm1Lisk/\Mlh1tm1Lisk
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 		increased intestinal adenocarcinoma incidence J:75745
increased intestinal adenoma incidence J:75745
increased lymphoma incidence J:75745
premature death J:75745
\Dnmt1tm3Jae/\Dnmt1tm2Enl
involves: 129S4/SvJae * BALB/c 		increased tumor incidence J:82979
postnatal growth retardation J:82979
normal reproductive system phenotype J:82979
\Dnmt1tm3Jae/\Dnmt1tm3Jae
involves: 129S4/SvJae * BALB/c 		no abnormal phenotype detected J:83179
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory