Dnmt1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dnmt1
DNA methyltransferase 1
MGI:94912

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
A^vy/A Dnmt1^MommeD2/Dnmt1⁺ involves: C57BL/6J * FVB/NJ	yellow coat color	J:99816
Apc^Min/Apc⁺ Dnmt1^tm1Jae/Dnmt1⁺ involves: 129S4/SvJae * C57BL/6J	intestine polyps	J:75230
Apc^Min/Apc⁺ Dnmt1^tm1Jae/Dnmt1^tm1Pwl involves: 129S4/SvJae * C57BL/6J	normal digestive/alimentary phenotype	J:75230
Apc^Min/Apc⁺ Dnmt1^tm1Pwl/Dnmt1⁺ involves: 129S4/SvJae * C57BL/6J	intestine polyps	J:75230
Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Dnmt1^tm2Jae/Dnmt1⁺ Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJae * C57BL/6 * CBA	anemia	J:196140
	decreased erythrocyte cell number	J:196140
Dmap1^tm1.2Jrc/Dmap1⁺ Dnmt1^tm2Jrc/Dnmt1^tm2Jrc involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	abnormal DNA methylation	J:172814
	transmission ratio distortion	J:172814
Dmap1^tm1.2Jrc/Dmap1^tm1.2Jrc Dnmt1^tm2Jrc/Dnmt1^tm2Jrc involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	embryonic lethality before implantation, complete penetrance	J:172814
Dnmt1^{tm1(tetO-BCL2)Sjk}/Dnmt1⁺ Tg(IghMyc)22Bri/0 Tg(MMTVtTA)1Mam/0 involves: 129S4/SvJae * C57BL/6	enlarged spleen	J:93549
	increased B cell derived lymphoma incidence	J:93549
	increased leukemia incidence	J:93549
	lethargy	J:93549
	premature death	J:93549
Dnmt1^tm1Enl/Dnmt1^tm1Enl H19^tm1Tilg/H19⁺ involves: 129S/SvEv * 129S4/SvJae	genetic imprinting	J:110857
Dnmt1^tm1Jae/Dnmt1⁺ Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	increased intestinal adenocarcinoma incidence	J:75745
	increased intestinal adenoma incidence	J:75745
	increased lymphoma incidence	J:75745
	premature death	J:75745
Dnmt1^tm1Jae/Dnmt1^tm1Pwl Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	increased lymphoma incidence	J:75745
	normal neoplasm	J:75745
	premature death	J:75745
Dnmt1^tm1Pwl/Dnmt1⁺ Mlh1^tm1Lisk/Mlh1^tm1Lisk involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	increased intestinal adenocarcinoma incidence	J:75745
	increased intestinal adenoma incidence	J:75745
	increased lymphoma incidence	J:75745
	premature death	J:75745
Dnmt1^tm3Jae/Dnmt1^tm2Enl involves: 129S4/SvJae * BALB/c	increased tumor incidence	J:82979
	postnatal growth retardation	J:82979
	normal reproductive system phenotype	J:82979
Dnmt1^tm3Jae/Dnmt1^tm3Jae involves: 129S4/SvJae * BALB/c	no abnormal phenotype detected	J:83179

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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