Mlh1^tm1Lisk
Targeted Allele Detail

Summary

• Symbol: Mlh1^tm1Lisk
• Name: mutL homolog 1; targeted mutation 1, Michael Liskay
• MGI ID: MGI:1857946
• Synonyms: Mlh1-
• Gene: Mlh1 Location: Chr9:111057296-111100854 bp, - strand Genetic Position: Chr9, 60.92 cM
• Alliance: Mlh1^tm1Lisk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34291
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of exon 4 with a Pgk-HPRT mini-gene. (J:34291)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mlh1^tm1Lisk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mlh1 Mutation: 42 strains or lines available

References

• Original: J:34291 Baker SM, et al., Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over [see comments]. Nat Genet. 1996 Jul;13(3):336-42
• All: 50 reference(s)