Scarb1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Scarb1
scavenger receptor class B, member 1
MGI:893578

43 phenotypes from 10 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Scarb1^Chohd1/Scarb1⁺ C3HeB/FeJ-Scarb1^Chohd1/Ieg	increased circulating cholesterol level	J:94145
	increased circulating HDL cholesterol level	J:94145
	increased circulating LDL cholesterol level	J:94145
Scarb1^{Hdlq1-129S1/SvImJ}/? involves: 129S1/SvImJ * C57BL/6J	increased circulating HDL cholesterol level	J:144089
Scarb1^{Hdlq1-NZB/BlNJ}/Scarb1^{Hdlq1-NZB/BlNJ} involves: NZB/BlNJ * SM/J	increased circulating HDL cholesterol level	J:76707, J:89309
Scarb1^{Hdlq1-NZB/BlNJ}/Scarb1^Hdlq1-SM/J involves: NZB/BlNJ * SM/J	increased circulating HDL cholesterol level	J:76707, J:89309
Scarb1^Hlb398/? C57BL/6J-Scarb1^Hlb398	increased circulating cholesterol level	J:82961
Scarb1^Hlb398/? C57BL/6J-Scarb1^Hlb398	increased circulating HDL cholesterol level	J:82961
Scarb1^Hlb398/Scarb1⁺ C57BL/6J-Scarb1^Hlb398	increased circulating HDL cholesterol level	J:152482
Scarb1^Hlb398/Scarb1^Hlb398 C57BL/6J-Scarb1^Hlb398	abnormal cholesterol homeostasis	J:152482
	abnormal lipid level	J:152482
	abnormal liver physiology	J:152482
	increased circulating cholesterol level	J:152482
	increased circulating HDL cholesterol level	J:152482
	increased circulating phospholipid level	J:152482
	increased circulating triglyceride level	J:152482
	normal reproductive system phenotype	J:152482
Scarb1^tm1.1Thh/Scarb1^tm1.1Thh B6.129X1-Scarb1^tm1.1Thh	female infertility	J:114663
	increased circulating cholesterol level	J:114663
	increased circulating HDL cholesterol level	J:114663
	increased circulating interleukin-6 level	J:114663
	increased susceptibility to atherosclerosis	J:114663
Scarb1^{tm1b(EUCOMM)Wtsi}/Scarb1⁺ C57BL/6N-Scarb1^{tm1b(EUCOMM)Wtsi}/Bay	abnormal sinus arrhythmia	J:211773
	cardiovascular system phenotype	J:211773
	decreased heart rate	J:211773
	prolonged PQ interval	J:211773
	prolonged RR interval	J:211773
	prolonged ST segment	J:211773
Scarb1^{tm1b(EUCOMM)Wtsi}/Scarb1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Scarb1^{tm1b(EUCOMM)Wtsi}/Bay	decreased vertical activity	J:211773
	enlarged heart	J:211773
	enlarged spleen	J:211773
	increased circulating cholesterol level	J:211773
	increased heart weight	J:211773
	increased spleen weight	J:211773
Scarb1^tm1Dhu/Scarb1^tm1Dhu involves: 129S4/SvJae * BALB/cByJ	abnormal cholesterol level	J:47439
	abnormal circulating HDL cholesterol level	J:47439
	abnormal lipid homeostasis	J:47439
	increased circulating HDL cholesterol level	J:47439
Scarb1^tm1Kri/Scarb1⁺ involves: 129S2/SvPas * C57BL/6	abnormal adrenal gland physiology	J:44187
	abnormal cholesterol level	J:44187
	abnormal lipid homeostasis	J:44187
	increased circulating cholesterol level	J:44187
Scarb1^tm1Kri/Scarb1^tm1Kri B6.129S2-Scarb1^tm1Kri	female infertility	J:73138
Scarb1^tm1Kri/Scarb1^tm1Kri involves: 129S2/SvPas	abnormal vascular wound healing	J:118063
Scarb1^tm1Kri/Scarb1^tm1Kri involves: 129S2/SvPas * C57BL/6	abnormal adrenal gland physiology	J:44187
	abnormal cellular cholesterol metabolism	J:216748
	abnormal cholesterol level	J:44187
	abnormal circulating cholesterol level	J:73138
	abnormal egg activation	J:216748
	abnormal embryonic tissue morphology	J:105226
	abnormal erythrocyte morphology	J:75090
	abnormal female meiosis	J:216748
	abnormal lipid homeostasis	J:44187
	abnormal oocyte morphology	J:105226
	anemia	J:75090
	failure of zygotic cell division	J:105226
	female infertility	J:73138, J:105226, J:216748
	impaired fertilization	J:216748
	increased cholesterol level	J:216748
	increased circulating cholesterol level	J:44187
	macrocytosis	J:75090
	neonatal lethality, incomplete penetrance	J:105226
	oocyte degeneration	J:216748
	poikilocytosis	J:75090
Scarb1^tm1Thh/Scarb1^tm1Thh B6.129X1-Scarb1^tm1Thh	increased circulating cholesterol level	J:114663
	increased circulating HDL cholesterol level	J:114663
	increased susceptibility to atherosclerosis	J:114663
Scarb1^tm1Thh/Scarb1^tm1Thh Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ B6.Cg-Scarb1^tm1Thh Speer6-ps1^{Tg(Alb-cre)21Mgn}	increased circulating cholesterol level	J:114663
	increased circulating HDL cholesterol level	J:114663
	increased circulating interleukin-6 level	J:114663
	increased susceptibility to atherosclerosis	J:114663

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