Scarb1^tm1Dhu
Targeted Allele Detail

Summary

• Symbol: Scarb1^tm1Dhu
• Name: scavenger receptor class B, member 1; targeted mutation 1, Dennis Huszar
• MGI ID: MGI:1928989
• Synonyms: SR-BI att
• Gene: Scarb1 Location: Chr5:125354151-125418158 bp, - strand Genetic Position: Chr5, 64.11 cM
• Alliance: Scarb1^tm1Dhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47439
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: Disruption of the putative promoter region by insertion of a vector. This is a hypomorphic allele; expression levels are reduced to varying degrees in different tissues. (J:47439)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scarb1 Mutation: 52 strains or lines available

References

• Original: J:47439 Varban ML, et al., Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol [see comments]. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4619-24
• All: 5 reference(s)