All Phenotypes Scarb1<tm1Dhu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scarb1^tm1Dhu
targeted mutation 1, Dennis Huszar
MGI:1928989

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scarb1^tm1Dhu/Scarb1^tm1Dhu	involves: 129S4/SvJae * BALB/cByJ	MGI:2174743
cx2	Ldlr^tm1Her/Ldlr^tm1Her Scarb1^tm1Dhu/Scarb1^tm1Dhu	involves: 129S4/SvJae * BALB/c * C57BL/6J	MGI:3623224

Allelic Composition	Scarb1^tm1Dhu/Scarb1^tm1Dhu
Genetic Background	involves: 129S4/SvJae * BALB/cByJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scarb1^tm1Dhu mutation (0 available); any Scarb1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:47439 )

abnormal circulating HDL cholesterol level ( J:47439 )

increased circulating cholesterol level ( J:47439 )

• serum cholesterol levels are 50-70% higher than control values

increased circulating HDL cholesterol level ( J:47439 )

• HDL levels are 51% greater than control values

Allelic Composition	Ldlr^tm1Her/Ldlr^tm1Her Scarb1^tm1Dhu/Scarb1^tm1Dhu
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1Her mutation (21 available); any Ldlr mutation (78 available)
Scarb1^tm1Dhu mutation (0 available); any Scarb1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:62371 )

• lesion size is significantly increased in males compared to LDL-receptor controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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