Scarb1^tm1Thh
Targeted Allele Detail

Summary

• Symbol: Scarb1^tm1Thh
• Name: scavenger receptor class B, member 1; targeted mutation 1, Thierry Huby
• MGI ID: MGI:3690316
• Synonyms: SR-BI^flox
• Gene: Scarb1 Location: Chr5:125354151-125418158 bp, - strand Genetic Position: Chr5, 64.11 cM
• Alliance: Scarb1^tm1Thh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114663
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: Exon 1 was flanked with loxP sites via homologous recombination. mRNA and protein levels are decreased, indicating that this is a hypomorphic allele. (J:114663)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scarb1 Mutation: 52 strains or lines available

References

• Original: J:114663 Huby T, et al., Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues. J Clin Invest. 2006 Oct;116(10):2767-76
• All: 6 reference(s)