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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cbl
Casitas B-lineage lymphoma
MGI:88279
49 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Cbltm1.1Hua/\Cbltm1.1Hua
\Lattm1Les/\Lattm1Les
involves: 129P2/OlaHsd 		abnormal thymus development J:91369
increased CD4-positive, alpha-beta T cell number J:91369
liver inflammation J:91369
lung inflammation J:91369
thymus hypoplasia J:91369
\Cbltm1.1Hua/\Cbltm1.1Hua
\Lcp2tm1Gak/\Lcp2tm1Gak
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal cytokine secretion J:91369
abnormal T cell differentiation J:91369
enlarged spleen J:91369
increased CD4-positive, alpha-beta T cell number J:91369
liver inflammation J:91369
lung inflammation J:91369
\Cbltm1.1Hua/\Cbltm1.1Hua
\Lcp2tm1Gak/\Lcp2tm1Gak
\Rag2tm1Fwa/\Rag2tm1Fwa
involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ 		abnormal T cell differentiation J:91369
\Cbltm1Ddlb/\Cbltm2Wlan
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal double-negative T cell morphology J:103366
abnormal foot pigmentation J:103366
abnormal lymph node cell ratio J:103366
abnormal spleen morphology J:103366
abnormal splenic cell ratio J:103366
abnormal T cell activation J:103366
abnormal T cell differentiation J:103366
abnormal T cell physiology J:103366
abnormal thymus morphology J:103366
abnormal thymus size J:103366
darkened coat color J:103366
decreased single-positive T cell number J:103366
enlarged spleen J:103366
increased ear pigmentation J:103366
increased spleen red pulp amount J:103366
increased tail pigmentation J:103366
prenatal lethality, incomplete penetrance J:103366
spleen hyperplasia J:103366
thymus hypoplasia J:103366
\Cbltm1Ddlb/\Cbltm2Wlan
involves: 129S1/Sv * C57BL/6 		abnormal enzyme/coenzyme activity J:121012
abnormal epididymal fat pad morphology J:121012
abnormal food intake J:121012
decreased body weight J:121012
decreased brown adipose tissue amount J:121012
decreased circulating free fatty acids level J:121012
decreased circulating insulin level J:121012
decreased circulating leptin level J:121012
decreased circulating triglyceride level J:121012
decreased susceptibility to diet-induced obesity J:121012
decreased total body fat amount J:121012
improved glucose tolerance J:121012
increased insulin sensitivity J:121012
increased oxygen consumption J:121012
\Cbltm1Soga/\Cbl+
\Tg(Tec-BCR/ABL1)5Hhi/0
involves: C57BL/6 * DBA/2 		premature death J:151543
\Cbltm1Soga/\Cbltm1Soga
\Tg(Tec-BCR/ABL1)5Hhi/0
involves: C57BL/6 * DBA/2 		enlarged lymph nodes J:151543
premature death J:151543
\Cbltm2Hua/\Cbltm2Hua
\Cblbtm1Hua/\Cblbtm1Hua
\Tg(Lck-cre)I57Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * ICR 		abnormal blood vessel morphology J:80427
abnormal immune system physiology J:80427
abnormal T cell morphology J:80427
decreased body weight J:80427
dermatitis J:80427
enlarged spleen J:80427
extramedullary hematopoiesis J:80427
increased T cell proliferation J:80427
liver fibrosis J:80427
premature death J:80427
\Cbltm2Wlan/\Cbltm2Wlan
involves: 129X1/SvJ * C57BL/6 		abnormal foot pigmentation J:103366
abnormal spleen morphology J:103366
abnormal thymus morphology J:103366
abnormal thymus size J:103366
darkened coat color J:103366
enlarged spleen J:103366
increased ear pigmentation J:103366
increased spleen red pulp amount J:103366
increased tail pigmentation J:103366
lethality throughout fetal growth and development, incomplete penetrance J:103366
neonatal lethality, incomplete penetrance J:103366
spleen hyperplasia J:103366
thymus hypoplasia J:103366
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory