Cbl^tm1Soga
Targeted Allele Detail

Summary

• Symbol: Cbl^tm1Soga
• Name: Casitas B-lineage lymphoma; targeted mutation 1, Seishi Ogawa
• MGI ID: MGI:4354652
• Gene: Cbl Location: Chr9:44054273-44145346 bp, - strand Genetic Position: Chr9, 24.72 cM
• Alliance: Cbl^tm1Soga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151543
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 3. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:151543)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbl Mutation: 57 strains or lines available

References

• Original: J:151543 Sanada M, et al., Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature. 2009 Aug 13;460(7257):904-8
• All: 1 reference(s)