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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bdnf
brain derived neurotrophic factor
MGI:88145
153 phenotypes from 21 alleles in 28 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern
involves: 129P2/OlaHsd 		abnormal cochlea morphology J:82462
abnormal crista ampullaris morphology J:82462
abnormal fungiform papillae morphology J:82462
abnormal geniculate ganglion morphology J:82462
abnormal gustatory system morphology J:82462
abnormal innervation J:82462
abnormal sensory neuron innervation pattern J:82462
abnormal sensory neuron morphology J:82462
abnormal vestibular ganglion morphology J:82462
normal hearing/vestibular/ear phenotype J:82462
impaired balance J:82462
impaired coordination J:82462
increased body weight J:82462
premature death J:82462
small nodose ganglion J:82462
vestibular ganglion degeneration J:82462
Bdnftm1.1Krj/Bdnf+
involves: 129S2/SvPas * C57BL/6 		abnormal dendritic spine morphology J:184139
normal nervous system phenotype J:184139
Bdnftm1.1Krj/Bdnftm1.1Krj
involves: 129S2/SvPas 		abnormal sensory neuron innervation pattern J:192549
Bdnftm1.1Tes/Bdnftm1.1Tes
B6.129X1-Bdnftm1.1Tes 		no abnormal phenotype detected J:146179
Bdnftm1.1Tmiz/Bdnf+
B6.Cg-Bdnftm1.1Tmiz 		abnormal nest building behavior J:303078
behavioral despair J:303078
increased body weight J:303078
increased food intake J:303078
Bdnftm1.1Tmiz/Bdnftm1.1Tmiz
B6.Cg-Bdnftm1.1Tmiz 		normal cardiovascular system phenotype J:303078
normal growth/size/body region phenotype J:303078
Bdnftm1Bail/Bdnftm1Bail
B6.129-Bdnftm1Bail 		abnormal brain interneuron morphology J:147571
abnormal inhibitory postsynaptic currents J:147571
abnormal nervous system physiology J:147571
abnormal synaptic plasticity J:147571
Bdnftm1Gdy/Bdnf+
involves: 129P2/OlaHsd 		small vestibular ganglion J:110692
vestibular ganglion degeneration J:110692
Bdnftm1Gdy/Bdnftm1Gdy
involves: 129P2/OlaHsd 		abnormal cochlear OHC afferent innervation pattern J:110692
abnormal motor coordination/balance J:25565
abnormal sensory neuron innervation pattern J:110692
decreased brain size J:25565
decreased sensory neuron number J:25565
hyperactivity J:25565
impaired righting response J:25565
postnatal growth retardation J:25565
postnatal lethality, incomplete penetrance J:25565
small nodose ganglion J:25565
small petrosal ganglion J:25565
small trigeminal ganglion J:25565
small vestibular ganglion J:25565, J:110692
vestibular ganglion degeneration J:110692
Bdnftm1Jae/Bdnftm1Jae
B6.129S4-Bdnftm1Jae 		abnormal gustatory papilla taste bud morphology J:90280
abnormal sensory neuron innervation pattern J:90280
Bdnftm1Jae/Bdnftm1Jae
involves: 129S4/SvJae 		abnormal cochlear ganglion morphology J:82462
abnormal crista ampullaris morphology J:82462
abnormal fungiform papillae morphology J:82462
abnormal innervation J:82462
abnormal sensory neuron innervation pattern J:82462
abnormal trigeminal nerve morphology J:123022
abnormal type I vestibular cell J:17123
abnormal vestibular ganglion morphology J:82462
abnormal vestibular nerve morphology J:17123
circling J:17123
deafness J:82462
decreased body size J:17123
decreased sensory neuron number J:17123, J:25566
head bobbing J:17123
head tilt J:17123
normal hearing/vestibular/ear phenotype J:17123
hyperactivity J:17123
impaired balance J:17123
impaired limb coordination J:17123
increased neuron apoptosis J:123022
normal nervous system phenotype J:17123
postnatal lethality, incomplete penetrance J:17123, J:82462
small geniculate ganglion J:25566, J:82462
small L4 dorsal root ganglion J:17123, J:82462
small mesencephalic trigeminal nucleus J:17123
small nodose ganglion J:17123, J:25566, J:82462
small petrosal ganglion J:25566
small trigeminal ganglion J:17123
small vestibular ganglion J:17123, J:25566
spinning J:17123
Bdnftm1Jae/Bdnftm1Jae
involves: 129S4/SvJae * BALB/c 		abnormal neuron apoptosis J:46125
abnormal neuron morphology J:46125
increased neuron number J:46125
Bdnftm1Jae/Bdnftm2(Ntf5)Jae
involves: 129S4/SvJae 		no abnormal phenotype detected J:61340
Bdnftm1Jben/Bdnf+
involves: C57BL/6 		abnormal neuron morphology J:111309
abnormal striatum morphology J:111309
decreased locomotor activity J:111309
weight loss J:111309
Bdnftm1Krj/Bdnf+
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas * C57BL/6J 		normal growth/size/body region phenotype J:84683
Bdnftm1Krj/Bdnftm1Krj
involves: 129S2/SvPas * C57BL/6 		abnormal dendrite morphology J:184139
abnormal GABAergic neuron morphology J:184139
abnormal nervous system electrophysiology J:184139
abnormal nervous system physiology J:184139
normal nervous system phenotype J:184139
Bdnftm1Krj/Bdnftm1Lfr
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas * C57BL/6J 		abnormal cerebral cortex morphology J:96903
abnormal hippocampus morphology J:96903
abnormal medium spiny neuron morphology J:96903
abnormal nest building behavior J:84683
abnormal visual cortex morphology J:84683
decreased body weight J:84683
decreased striatum size J:96903
delayed eyelid opening J:84683
increased aggression J:84683
limb grasping J:96903
obese J:84683
premature death J:84683
reduced fertility J:84683
thin cerebral cortex J:84683
Bdnftm1Krj/Bdnftm1Lfr
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S2/SvPas * C57BL/6 * CBA 		abnormal substantia nigra morphology J:99291
abnormal substantia nigra pars compacta morphology J:99291
impaired coordination J:99291
limb grasping J:99291
Bdnftm1Lfr/Bdnf+
involves: 129S2/SvPas * C57BL/6J 		obese J:84683
Bdnftm1Lfr/Bdnftm1Lfr
involves: 129S2/SvPas 		abnormal circumvallate papillae morphology J:55127
abnormal fungiform papillae morphology J:55127
abnormal gustatory papilla taste bud morphology J:55127
decreased body size J:55127
short tongue J:55127
shortened head J:55127
Bdnftm1Lfr/Bdnftm1Lfr
involves: 129S2/SvPas * C57BL/6 		abnormal cerebellum external granule cell layer morphology J:67231
abnormal cranial ganglia morphology J:67231
abnormal locomotor activation J:67231
abnormal motor capabilities/coordination/movement J:67231
abnormal neuron differentiation J:67231
abnormal sensory ganglion morphology J:67231
abnormal somatic sensory system morphology J:67231
abnormal vestibular ganglion morphology J:67231
ataxia J:67231
decreased pulmonary respiratory rate J:67231
decreased sensory neuron number J:67231
hunched posture J:67231
impaired righting response J:67231
postnatal lethality, complete penetrance J:67231
small dorsal root ganglion J:67231
small geniculate ganglion J:67231
small mesencephalic trigeminal nucleus J:67231
small nodose ganglion J:67231
small petrosal ganglion J:67231
spinning J:67231
Bdnftm1Limm/Bdnftm1Limm
Tg(Camk2a-cre)T50Stl/0
involves: BALB/c * C57BL/6 		abnormal depression-related behavior J:129526
abnormal liquid preference J:129526
increased locomotor activity J:129526
Bdnftm1Limm/Bdnftm1Limm
Tg(GFAP-cre)25Mes/0
involves: FVB/N 		abnormal depression-related behavior J:129526
increased locomotor activity J:129526
Bdnftm1Meg/Bdnftm1Meg
Not Specified 		abnormal axon pruning J:139381
Bdnftm1Msd/Bdnftm1Msd
Mapttm1(cre)Nagy/Mapt+
involves: 129S1/Sv * 129X1/SvJ 		normal mortality/aging J:131394
normal nervous system phenotype J:131394
reduced long-term potentiation J:131394
Bdnftm1Par/Bdnf+
B6.129S1-Bdnftm1Par 		abnormal CNS synaptic transmission J:59077
abnormal locomotor activation J:59077
abnormal serotonergic neuron morphology J:59077
abnormal serotonin level J:59077
decreased vertical activity J:59077
increased aggression towards male mice J:59077, J:144845
increased body weight J:144845
increased circulating insulin level J:59077
increased susceptibility to age related obesity J:59077
polyphagia J:59077
Bdnftm1Par/Bdnf+
involves: 129S1/Sv 		decreased exploration in new environment J:113019
decreased hippocampus volume J:113019
increased aggression towards male mice J:113019
increased anxiety-related response J:113019
increased body weight J:113019
Bdnftm1Par/Bdnftm1Par
involves: 129S1/Sv 		abnormal barrel cortex morphology J:103935
abnormal dorsal root ganglion morphology J:60927
abnormal sensory neuron innervation pattern J:103935
abnormal somatic nervous system morphology J:44286
decreased sensory neuron number J:44286, J:60927
increased neuron apoptosis J:60927
postnatal lethality, complete penetrance J:44286
small dorsal root ganglion J:60927
small geniculate ganglion J:44286
small L4 dorsal root ganglion J:44286
small nodose ganglion J:44286
small petrosal ganglion J:44286
small trigeminal ganglion J:44286, J:60927
Bdnftm1Sieg/Bdnftm1Sieg
involves: 129S/SvEv * C57 		no abnormal phenotype detected J:85602
Bdnftm1Sieg/Bdnftm1Sieg
Tg(Camk2a-cre)1Szi/0
involves: 129S/SvEv * C57BL/6 * CBA 		reduced long-term potentiation J:85602
Bdnftm1Sieg/Bdnftm1Sieg
Tg(Camk2a-cre)3Szi/0
involves: 129S/SvEv * C57BL/6 * CBA 		no abnormal phenotype detected J:85602
Bdnftm1Tbn/Bdnf+
involves: 129S4/SvJae * NMRI 		abnormal excitatory postsynaptic potential J:64962
impaired synaptic plasticity J:64962
reduced long-term potentiation J:64962
Bdnftm1Tbn/Bdnftm1Tbn
involves: 129S2/SvPas 		abnormal adrenergic neuron morphology J:56217
abnormal innervation J:56217
abnormal keratinocyte morphology J:54992
abnormal sympathetic system morphology J:56217
Bdnftm1Tbn/Bdnftm1Tbn
involves: 129S4/SvJae * NMRI 		abnormal cochlear OHC afferent innervation pattern J:84871
abnormal colon goblet cell morphology J:110612
abnormal colon morphology J:110612
abnormal excitatory postsynaptic potential J:64962
abnormal hair cycle J:53271
abnormal intestine morphology J:110612
decreased body weight J:64962
decreased sensory neuron number J:64962
impaired balance J:64962
impaired limb coordination J:64962
impaired synaptic plasticity J:64962
postnatal growth retardation J:64962
postnatal lethality, complete penetrance J:64962
reduced long-term potentiation J:64962
small dorsal root ganglion J:64962
Bdnftm1Yab/Bdnftm1Yab
Mapttm1(cre)Nagy/Mapt+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal dendrite morphology J:157932
abnormal locomotor activation J:157932
abnormal neuron morphology J:157932
abnormal optic nerve morphology J:157932
decreased body weight J:157932
decreased brain size J:157932
decreased brain weight J:157932
decreased striatum size J:157932
increased anxiety-related response J:157932
increased body weight J:157932
limb grasping J:157932
postnatal growth retardation J:157932
postnatal lethality, complete penetrance J:157932
Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
involves: 129S4/SvJae 		decreased body weight J:61340
excessive scratching J:61340
female infertility J:61340
normal nervous system phenotype J:61340
reduced male fertility J:61340
Bdnftm3Jae/Bdnftm3Jae
involves: 129S4/SvJae 		no abnormal phenotype detected J:71969
Bdnftm3Jae/Bdnftm3Jae
involves: 129S4/SvJae 		normal behavior/neurological phenotype J:157538
impaired cued conditioning behavior J:157538
Bdnftm3Jae/Bdnftm3Jae
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * CBA/J 		abnormal hippocampus CA2 region morphology J:106973
abnormal homeostasis J:71969
abnormal olfactory bulb morphology J:106973
decreased brain weight J:106973
hyperactivity J:71969
increased aggression towards male mice J:71969
increased anxiety-related response J:71969
increased body length J:71969
increased cholesterol level J:71969
increased circulating glucose level J:71969
increased circulating insulin level J:71969
increased circulating leptin level J:71969
insulin resistance J:71969
limb grasping J:106973
obese J:71969
polyphagia J:71969
reduced female fertility J:71969
Bdnftm3Jae/Bdnftm3Jae
Tg(Camk2a-cre)159Kln/0
involves: 129S4/SvJae * CBA/J 		hyperactivity J:71969
obese J:71969
Bdnftm3Jae/Bdnftm3Jae
Tg(Cck-cre)CKres/0
involves: 129S4/SvJae * C57BL/6 		normal behavior/neurological phenotype J:157538
impaired cued conditioning behavior J:157538
Bdnftm3Jae/Bdnftm3Jae
Tg(Eno2tTA)5030Nes/0
Tg(tetO-cre)1Jaw/0
involves: 129/Sv * C57BL/6 * ICR * SJL 		abnormal contextual conditioning behavior J:91563
abnormal cued conditioning behavior J:91563
hyperactivity J:91563
impaired behavioral response to xenobiotic J:91563
reduced long-term potentiation J:91563
Bdnftm3Jae/Bdnftm3Jae
Tg(Syn1-cre)671Jxm/0
involves: 129/Sv * C57BL/6 * ICR 		abnormal kindling response J:91467
Tg(Bdnf)1Kma/0
involves: C3H * C57BL/6J 		abnormal cutaneous/subcutaneous mechanoreceptor morphology J:65163
enlarged Meissner's corpuscles J:65163
hyperinnervation of hair guard cells J:65163
hyperinnervation of hair-down cells J:65163
hyperinnervation of hair-tylotrich cells J:65163
hyperinnervation of Meissner's corpuscle J:65163
hyperinnervation of Merkel's receptor J:65163
increased Merkel's receptor number J:65163
Tg(Bdnf)1Paus/0
involves: FVB 		abnormal adrenergic neuron morphology J:56217
abnormal hair cycle J:53271
abnormal innervation J:56217
abnormal keratinocyte morphology J:54992
abnormal sensory neuron innervation pattern J:110609
abnormal sympathetic system morphology J:56217
increased Merkel's receptor number J:110609
short hair J:53271
thick epidermis J:54992
thin skin J:53271
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04/23/2024
MGI 6.23 		The Jackson Laboratory