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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mfn2
mitofusin 2
MGI:2442230
40 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+
Mfn2tm3Dcc/Mfn2tm3Dcc
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J 		abnormal axonal transport J:188347
abnormal dopaminergic neuron morphology J:188347
abnormal innervation J:188347
abnormal mitochondrial morphology J:188347
abnormal striatum morphology J:188347
bradykinesia J:188347
decreased body size J:188347
decreased body weight J:188347
decreased locomotor activity J:188347
decreased vertical activity J:188347
hunched posture J:188347
kyphosis J:188347
loss of dopaminergic neurons J:188347
neurodegeneration J:188347
premature death J:188347
Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+
Mfn2tm1.1Arte/Mfn2tm1.1Arte
Slc6a3tm1(cre)Lrsn/Slc6a3+
involves: 129S1/Sv * 129X1/SvJ 		abnormal dopaminergic neuron morphology J:188337
abnormal dorsal striatum morphology J:188337
abnormal mitochondrial shape J:188337
decreased mitochondrial number J:188337
increased mitochondrial size J:188337
Meox2tm1(cre)Sor/Meox2+
Mfn1tm1Dcc/Mfn1tm2Dcc
Mfn2tm1Dcc/Mfn2tm3Dcc
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss 		neonatal lethality, complete penetrance J:132329
Meox2tm1(cre)Sor/Meox2+
Mfn1tm1Dcc/Mfn1tm2Dcc
Mfn2tm3Dcc/Mfn2+
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss 		neonatal lethality, complete penetrance J:132329
Meox2tm1(cre)Sor/Meox2+
Mfn1tm2Dcc/Mfn1+
Mfn2tm1Dcc/Mfn2tm3Dcc
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss 		decreased body size J:132329
impaired limb coordination J:132329
impaired righting response J:132329
neonatal lethality, incomplete penetrance J:132329
postnatal lethality, complete penetrance J:132329
Mfn1tm1Dcc/Mfn1tm1Dcc
Mfn2tm1Dcc/Mfn2tm1Dcc
involves: 129S/SvEv 		prenatal lethality J:81438
Mfn1tm1Dcc/Mfn1tm2Dcc
Mfn2tm1Dcc/Mfn2tm3Dcc
Tg(Pcp2-cre)2Mpin/0
involves: 129 * 129S4/SvJaeSor * Black Swiss 		abnormal Purkinje cell dendrite morphology J:132329
abnormal respiratory electron transport chain J:132329
Purkinje cell degeneration J:132329
Mfn1tm1Dcc/Mfn1tm2Dcc
Mfn2tm3Dcc/Mfn2+
involves: 129 * 129S4/SvJaeSor * Black Swiss 		no abnormal phenotype detected J:132329
Mfn1tm2Dcc/Mfn1tm2Dcc
Mfn2tm3Dcc/Mfn2tm3Dcc
Tg(Stra8-icre)1Reb/0
involves: 129 * C57BL/6J * FVB/NJ 		abnormal mitochondrial morphology J:305430
abnormal spermatid morphology J:305430
abnormal spermatocyte morphology J:305430
abnormal spermatogenesis J:305430
arrest of male meiosis J:305430
decreased male germ cell number J:305430
decreased testis weight J:305430
male infertility J:305430
seminiferous tubule degeneration J:305430
small epididymis J:305430
small seminiferous tubules J:305430
small testis J:305430
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory