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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Twnk
twinkle mtDNA helicase
MGI:2137410
23 phenotypes from 7 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Tg(ACTB-Twnk)#Suom/0
involves: FVB/N
normal cellular phenotype J:104378
Tg(ACTB-Twnk*)DSuom/0
involves: FVB/N
abnormal brain morphology J:104378
abnormal cellular respiration J:104378
abnormal DNA repair J:104378
abnormal mitochondrial morphology J:104378
abnormal muscle fiber morphology J:104378
normal behavior/neurological phenotype J:104378
increased mitochondrial fission J:104378
normal mortality/aging J:104378
normal muscle phenotype J:104378
Tg(ACTB-Twnk*A360T)HSuom/0
involves: FVB/N
abnormal mitochondrial physiology J:104378
abnormal muscle fiber morphology J:104378
normal behavior/neurological phenotype J:104378
normal mortality/aging J:104378
normal muscle phenotype J:104378
Tg(Th-Twnk*,-EGFP)2Gcor/0
involves: C57BL/6J
abnormal autophagy J:188914
abnormal cell physiology J:188914
abnormal mitochondrial morphology J:188914
abnormal mitochondrial physiology J:188914
decreased dopaminergic neuron number J:188914
impaired coordination J:188914
loss of dopaminergic neurons J:188914
Tg(Twnk)1Lrsn/0
Not Specified
no abnormal phenotype detected J:194965
Twnktm1.1Lrsn/Twnktm1.1Lrsn
Tg(Ckmm-cre)5Khn/0
involves: C57BL/6 * FVB
abnormal mitochondrial morphology J:194965
abnormal respiratory electron transport chain J:194965
enlarged heart J:194965
premature death J:194965
Twnktm1.2Lrsn/Twnktm1.2Lrsn
involves: C57BL/6
abnormal embryo development J:194965
embryonic lethality between somite formation and embryo turning, complete penetrance J:194965
prenatal lethality, complete penetrance J:194965

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory